Search Results - "Shim, Hyun J."

Pharmacokinetics of DA-8159, a new erectogenic, after intravenous and oral administration to rats: hepatic and intestinal first-pass effects by Shim, Hyun J, Kim, Yu C, Park, Kyung J, Kim, Dong S, Kwon, Jong W, Kim, Won B, Lee, Myung G

“…The purposes of this study were to report dose-independent (after intravenous administration) and dose-dependent (after oral administration) area under the…”
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In vitro evaluation of potential transporter‐mediated drug interactions of evogliptin by Lee, Dae Y., Chae, Hye W., Shim, Hyun J.

“…To date, little is known about the transporter‐mediated drug–drug interaction (DDI) potential of evogliptin, a novel DPP‐4 inhibitor. The objective of this…”
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Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics by Shim, Hyun J., Kim, Yu C., Lee, Joo H., Kwon, Jong W., Kim, Won B., Kim, Yoon G., Kim, So H., Lee, Myung G.

“…Time‐averaged total body clearance (Cl) and apparent volume of distribution at steady state (VSS) of DA‐8159 after intravenous administration to mice (30…”
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Pharmacokinetics of a New Carbapenem, DA-1131, after Intravenous Administration to Rats with Uranyl Nitrate-Induced Acute Renal Failure by KIM, S. H, SHIM, H. J, KIM, W. B, LEE, M. G

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Subacute toxicities and toxicokinetics of DA-8159, a new phosphodiesterase type V inhibitor, after single and 4-Week repeated oral administration in rats by Shim, Hyun J., Kim, Yu C., Jang, Ji M., Park, Kyung J., Kim, Dong H., Kang, Kyung K., Ahn, Byoung O., Kwon, Jong W., Kim, Won B., Lee, Myung G.

“…The subacute toxicities (10 male and 10 female rats at each dose) and the toxicokinetics (5 male rats at each dose) of DA‐8159, a new phosphodiesterase type V…”
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Pharmacokinetics of DA-6034, an agent for inflammatory bowel disease, in rats and dogs: Contribution of intestinal first-pass effect to low bioavailability in rats by Chung, Hye J., Choi, Young H., Choi, Hye D., Jang, Ji M., Shim, Hyun J., Yoo, Moohi, Kwon, Jong W., Lee, Myung G.

“…The pharmacokinetics of DA-6034 in rats and dogs and first-pass effect in rats were examined. After intravenous administration, the dose-normalized AUC 0–∞…”
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Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous DA-8159, a new erectogenic, in rats by Kim, Yu C., Shim, Hyun J., Lee, Joo H., Kim, Soon H., Kwon, Jong W., Kim, Won B., Lee, Myung G.

“…In order to find what types of hepatic microsomal cytochrome P450 (CYP) isozymes are involved in the metabolism of DA‐8159 and in the formation of DA‐8164 in…”
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Pharmacokinetics of intravenous and oral DA-8159, a new erectogenic, in rats with protein-calorie malnutrition by Shim, Hyun J., Kim, Yu C., Lee, Joo H., Ahn, Byung O., Kwon, Jong W., Kim, Won B., Lee, Inchul, Lee, Myung G.

“…Influence of dietary protein deficiency on the pharmacokinetics of DA‐8159 and one of its metabolites, DA‐8164, was investigated after intravenous and oral…”
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Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique by Shim, Hyun J., Lee, Eun J., Kim, So H., Kim, Soon H., Yoo, Moohi, Kwon, Jong W., Kim, Won B., Lee, Myung G.

“…Various factors influencing the protein binding of DA‐8159 to 4% human serum albumin (HSA) were evaluated using an equilibrium dialysis technique at an initial…”
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Species differences in the formation of DA-8164 after intravenous and/or oral administration of DA-8159, a new erectogenic, to mice, rats, rabbits, dogs and humans by Shim, Hyun J., Kim, Yu C., Lee, Joo H., Park, Kyung J., Kwon, Jong W., Kim, Won B., Lee, Myung G.

“…Species differences in the formation of DA‐8164 after intravenous and/or oral administration of DA‐8159 to mice, rats, rabbits, dogs and humans were…”
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Pharmacokinetic changes of DA-8159, a new erectogenic, and one of its metabolites, DA-8164 after intravenous and oral administration of DA-8159 to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats by Kim, Yu C., Shim, Hyun J., Lee, Joo H., Kim, Dong S., Kwon, Jong W., Kim, Won B., Lee, Inchul, Lee, Myung G.

“…The pharmacokinetics of DA‐8159 and one of its metabolites, DA‐8164, were compared after intravenous and oral administration of DA‐8159 at a dose of 30 mg/kg…”
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Pharmacokinetic changes of DA-8159, a new erectogenic, after intravenous and oral administration to rats with acute renal failure induced by uranyl nitrate by Shim, Hyun J., Kim, Yu C., Kim, Eun J., Kim, Dong G., Kwon, Jong W., Kim, Won B., Lee, Myung G.

“…The pharmacokinetic parameters of DA‐8159, a new erectogenic, were compared after intravenous and oral administration of the drug at a dose of 30 mg/kg to…”
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Subacute toxicities and toxicokinetics of a new erectogenic, DA-8159, after single and 4-week repeated oral administration in dogs by Shim, Hyun J., Lee, Eun J., Kim, Jung H., Kim, Soon H., Kwon, Jong W., Kim, Won B., Cha, Shin-W., Lee, Myung G.

“…The subacute toxicities and toxicokinetics of a new erectogenic, DA‐8159, were evaluated after single (at the 1st day) and 4‐week (at the 28th day) oral…”
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Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population by Cui, Lian-Hua, Shin, Min-Ho, Kweon, Sun-Seog, Kim, Hee Nam, Song, Hye-Rim, Piao, Jin-Mei, Choi, Jin-Su, Shim, Hyun Jeong, Hwang, Jun Eul, Kim, Hyeong-Rok, Park, Young-Kyu, Kim, Soo-Hyun

“…This study was designed to investigate an association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of gastric and…”
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Efficacy of entecavir in treatment-naïve patients with hepatitis B virus-related decompensated cirrhosis by Shim, Ju Hyun, Lee, Han Chu, Kim, Kang Mo, Lim, Young-Suk, Chung, Young-Hwa, Lee, Yung Sang, Suh, Dong Jin

“…Background & Aims The effect of entecavir (ETV) therapy on viral suppression and hepatic function in hepatitis B virus (HBV) patients with decompensated…”
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Clinical outcome of 251 patients with extrahepatic metastasis at initial diagnosis of hepatocellular carcinoma: Does transarterial chemoembolization improve survival in these patients? by Yoo, Dong-Jun, Kim, Kang Mo, Jin, Young-Joo, Shim, Ju Hyun, Ko, Gi-Young, Yoon, Hyun-Ki, Sung, Kyu-Bo, Lee, Jae-Lyun, Kang, Yoon-Koo, Lim, Young-Suk, Lee, Han Chu, Chung, Young-Hwa, Lee, Yung Sang, Suh, Dong Jin

“…Background and Aims:  The therapeutic efficacy of transarterial chemoembolization (TACE) has not been evaluated in hepatocellular carcinoma (HCC) patients with…”
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Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma by Lee, Joo Ho, Chung, Young‐Hwa, Kim, Jeong A., Shim, Ju Hyun, Lee, Danbi, Lee, Han Chu, Shin, Eun‐Soon, Yoon, Jung Hwan, Kim, Byung Ik, Bae, Si Hyun, Koh, Kwang Cheol, Park, Neung‐Hwa

“…BACKGROUND: Sorafenib currently sets the new standard for advanced hepatocellular carcinoma (HCC). It has been suggested that Asian patients with HCC have…”
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Maximum number of target lesions required to measure responses to transarterial chemoembolization using the enhancement criteria in patients with intrahepatic hepatocellular carcinoma by Shim, Ju Hyun, Lee, Han Chu, Won, Hyung Jin, Shin, Yong Moon, Kim, Kang Mo, Lim, Young-Suk, Suh, Dong Jin

“…Background & Aims The European Association for the Study of the Liver (EASL) criteria and, more recently, the modified Response Evaluation Criteria in Solid…”
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Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone by Shim, Ju Hyun, Suh, Dong Jin, Kim, Kang Mo, Lim, Young‐Suk, Lee, Han Chu, Chung, Young‐Hwa, Lee, Yung Sang

“…Entecavir (ETV) is currently recommended as a rescue therapy purely for adefovir (ADV)‐resistant chronic hepatitis B virus (HBV) infections. We evaluated the…”
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Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1‐positive hepatocellular carcinoma by Lee, Danbi, Chung, Young‐Hwa, Kim, Jeong A., Park, Won Hyung, Jin, Young‐Joo, Shim, Ju Hyun, Ryu, Soo Hyung, Jang, Myoung Kuk, Yu, Eunsil, Lee, Young Joo

“…BACKGROUND Metastatic tumor antigen 1 (MTA1) overexpression is closely associated with postoperative recurrence of hepatocellular carcinoma (HCC). It has been…”
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