Search Results - "Shilovskiy, Igor P."
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Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer
Published in Immunity (Cambridge, Mass.) (15-01-2019)“…Chronic inflammation drives the progression of colorectal cancer (CRC). Increased expression of interleukin (IL)-17A is associated with poor prognosis, and…”
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Murine model of steroid-resistant neutrophilic bronchial asthma as an attempt to simulate human pathology
Published in Journal of immunological methods (01-06-2022)“…Bronchial asthma (BA) is a heterogeneous chronic inflammatory disease of the airways. The majority of patients with mild to moderate BA develop Th2-biased…”
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Cell-Penetrating Peptides as Vehicles for Delivery of Therapeutic Nucleic Acids. Mechanisms and Application in Medicine
Published in Biochemistry (Moscow) (01-11-2023)“…Currently, nucleic acid therapeutics are actively developed for the treatment and prophylactic of metabolic disorders and oncological, inflammatory, and…”
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Role of STAT3 Transcription Factor in Pathogenesis of Bronchial Asthma
Published in Biochemistry (Moscow) (01-11-2021)“…Bronchial asthma is a heterogeneous chronic inflammatory disease of airways. The studies of molecular and cellular mechanisms of bronchial asthma have…”
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Role and Molecular Mechanisms of Alternative Splicing of Th2-Cytokines IL-4 and IL-5 in Atopic Bronchial Asthma
Published in Biochemistry (Moscow) (01-10-2023)“…Bronchial asthma (BA) is a heterogeneous chronic inflammatory disease of the respiratory tract. Allergic (atopic) asthma is the most common (up to 80% of…”
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Molecular and Cellular Mechanisms of Respiratory Syncytial Viral Infection: Using Murine Models to Understand Human Pathology
Published in Biochemistry (Moscow) (01-03-2021)“…Respiratory syncytial virus (RSV) causes severe pathology of the lower respiratory tract in infants, immunocompromised people, and elderly. Despite decades of…”
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A novel peptide dendrimer LTP efficiently facilitates transfection of mammalian cells
Published in Organic & biomolecular chemistry (07-11-2018)“…One of the urgent problems of gene therapy is the search for effective transfection methods. Synthetic cationic peptides (CPs) are considered to be one of the…”
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Genotoxicity of cationic lipopeptide nanoparticles
Published in Toxicology letters (01-08-2020)“…•Cationic lipopeptide nanoparticles caused DNA damage in liver, lung and kidney of mice.•Genotoxicity was confirmed in vitro on human blood cells.•No increase…”
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Small interfering RNAs targeted to interleukin-4 and respiratory syncytial virus reduce airway inflammation in a mouse model of virus-induced asthma exacerbation
Published in Human gene therapy (01-07-2014)“…Asthma exacerbations are caused primarily by viral infections. Antisense and small interfering RNA (siRNA) technologies have gained attention as potential…”
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Linear and dendrimeric antiviral peptides: design, chemical synthesis and activity against human respiratory syncytial virus
Published in Journal of materials chemistry. B, Materials for biology and medicine (01-04-2020)“…Respiratory syncytial virus (RSV) is one of the most common viral pathogens. It is especially dangerous for newborns and young children. In some cases it could…”
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Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate
Published in Mendeleev communications (01-11-2017)“…[Display omitted] A drug delivery system based on liposomes has been modified by targeted vectors based on a glycoconjugate, and the vector structure has been…”
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