Search Results - "Shilatifard, Ali"

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis by Shilatifard, Ali

“…The Saccharomyces cerevisiae Set1 COMPASS was the first histone H3 lysine 4 (H3K4) methylase identified over 10 years ago. Since then, it has been demonstrated…”
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Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation by Shilatifard, Ali

“…Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the…”
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Epigenetic modifications of histones in cancer by Zhao, Zibo, Shilatifard, Ali

“…The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In…”
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The roles of Polycomb repressive complexes in mammalian development and cancer by Piunti, Andrea, Shilatifard, Ali

“…More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila melanogaster . Later, a group of diverse genes collectively called…”
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COMPASS and SWI/SNF complexes in development and disease by Cenik, Bercin K., Shilatifard, Ali

“…The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes to counteract repressive developmental gene…”
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Epigenetic balance of gene expression by Polycomb and COMPASS families by Piunti, Andrea, Shilatifard, Ali

“…Epigenetic regulation of gene expression in metazoans is central for establishing cellular diversity, and its deregulation can result in pathological…”
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Epigenetics of hematopoiesis and hematological malignancies by Hu, Deqing, Shilatifard, Ali

“…Hematological malignancies comprise a diverse set of lymphoid and myeloid neoplasms in which normal hematopoiesis has gone awry and together account for ∼10%…”
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Born to run: control of transcription elongation by RNA polymerase II by Chen, Fei Xavier, Smith, Edwin R., Shilatifard, Ali

“…The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an integral part of the implementation of gene expression programmes during…”
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Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression by Shilatifard, Ali

“…It is more evident now than ever that nucleosomes can transmit epigenetic information from one cell generation to the next. It has been demonstrated during the…”
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Chromatin signatures of cancer by Morgan, Marc A, Shilatifard, Ali

“…Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability…”
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The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes by Smith, Edwin, Shilatifard, Ali

“…Posttranslational modifications of histones are coupled in the regulation of the cellular processes involving chromatin, such as transcription, replication,…”
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The super elongation complex (SEC) family in transcriptional control by Luo, Zhuojuan, Lin, Chengqi, Shilatifard, Ali

“…The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive…”
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The super elongation complex (SEC) and MLL in development and disease by Smith, Edwin, Lin, Chengqi, Shilatifard, Ali

“…Transcriptional regulation at the level of elongation is vital for the control of gene expression and metazoan development. The mixed lineage leukemia (MLL)…”
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SET for life: biochemical activities and biological functions of SET domain-containing proteins by Herz, Hans-Martin, Garruss, Alexander, Shilatifard, Ali

“…•An overview on the substrates of SET domain-containing proteins is provided.•Protein complexes of SET domain-containing proteins are described.•Biological…”
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Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer by Piunti, Andrea, Shilatifard, Ali

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Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide by Chen, Fei, Gao, Xin, Shilatifard, Ali

“…Transcription by RNA polymerase II (Pol II) in metazoans is regulated in several steps, including preinitiation complex (PIC) formation, initiation, Pol II…”
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The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers by Hu, Deqing, Gao, Xin, Morgan, Marc A., Herz, Hans-Martin, Smith, Edwin R., Shilatifard, Ali

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Covalent modifications of histones during development and disease pathogenesis by Shilatifard, Ali, Bhaumik, Sukesh R, Smith, Edwin

“…Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as…”
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Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis by Shilatifard, Ali, Mohan, Man, Lin, Chengqi, Guest, Erin

“…This article discusses the possible function of the super elongation complex (SEC) and the DOT1 H3K79 methyltransferase complex (DotCom) in leukaemia that is…”
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Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing by Liang, Kaiwei, Gao, Xin, Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Smith, Edwin, Shilatifard, Ali

“…Cyclin-dependent kinase 9 (CDK9) and CDK12 have each been demonstrated to phosphorylate the RNA polymerase II C-terminal domain (CTD) at serine 2 of the heptad…”
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