Search Results - "Shilabin, Abbas G."

An inhibitory compound produced by a soil isolate of Rhodococcus has strong activity against the veterinary pathogen R. equi by Ward, Amber L, Reddyvari, Pushpavathi, Borisova, Ralitsa, Shilabin, Abbas G, Lampson, Bert C

“…Complete genome sequencing of dozens of strains of the soil bacterium Rhodococcus has revealed the presence of many cryptic biosynthetic gene clusters,…”
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Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor by Ospanov, Meirambek, Sulochana, Suresh P, Paris, Jason J, Rimoldi, John M, Ashpole, Nicole, Walker, Larry, Ross, Samir A, Shilabin, Abbas G, Ibrahim, Mohamed A

“…Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is…”
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Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space by Ibrahim, Mohamed A, El-Alfy, Abir T, Ezel, Kelly, Radwan, Mohamed O, Shilabin, Abbas G, Kochanowska-Karamyan, Anna J, Abd-Alla, Howaida I, Otsuka, Masami, Hamann, Mark T

“…In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing…”
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Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines by Annor-Gyamfi, Joel K., Jarrett, John M., Osazee, Joseph O., Bialonska, Dobrusia, Whitted, Crystal, Palau, Victoria E., Shilabin, Abbas G.

“…Cancer remains the second major cause of death in the world. Thus, there is a pressing need to identify potential synthetic route for the development of novel…”
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Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments by Obaji, Hadi, Shilabin, Abbas G., Majumdar, Soumyajit, Ibrahim, Mohamed A.

“…Pyrrolobenzodiazepines (PBDs) are a potent class of compounds that have been analyzed since the 1960s and are found naturally in a wide variety of species…”
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First in class (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs as selective CB2 modulators targeting neurodegenerative disorders by Mingle, David, Ospanov, Meirambek, Radwan, Mohamed O., Ashpole, Nicole, Otsuka, Masami, Ross, Samir A., Walker, Larry A., Shilabin, Abbas G., Ibrahim, Mohamed A.

“…Newly designed pyrrolo[2,1-c][1,4]benzodiazepines tricyclic skeleton has shown potential clusters of cannabinoid receptors CB1/CB2 selective ligands. CB2 plays…”
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Specificity and mechanism of mandelamide hydrolase catalysis by Adediran, S.A., Wang, Pan-Fen, Shilabin, Abbas G., Baron, Charles A., McLeish, Michael J., Pratt, R.F.

“…The best-studied amidase signature (AS) enzyme is probably fatty acid amide hydrolase (FAAH). Closely related to FAAH is mandelamide hydrolase (MAH), whose…”
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β-Peptide coatings by surface-initiated polymerization by Chen, Li, Lei, Yong, Shilabin, Abbas G, Delaney, James D, Baran, George R, Sieburth, Scott McN

“…Homopolymers of β-lactams can be grown by surface-initiated polymerization. These surface-linked β-peptides are living polymers with the potential to be…”
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4-Quinolones as Noncovalent Inhibitors of High Molecular Mass Penicillin-Binding Proteins by Shilabin, Abbas G, Dzhekieva, Liudmila, Misra, Pushpa, Jayaram, B, Pratt, R. F

“…Penicillin-binding proteins (PBPs) are important bacterial enzymes that carry out the final steps of bacterial cell wall assembly. Their DD-transpeptidase…”
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2- N-Methyl modifications and SAR studies of manzamine A by Ibrahim, Mohamed A., Shilabin, Abbas G., Prasanna, Sivaprakasam, Jacob, Melissa, Khan, Shabana I., Doerksen, Robert J., Hamann, Mark T.

“…Mono- and di-methylated quaternary carbolinium salts of manzamine A were synthesized and evaluated for their antimalarial activity and cytotoxicity and their…”
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