Search Results - "Shikhaliev, Khidmet"
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Synthesis of 4,5-Dihydro-1H-[1,2]dithiolo[3,4-c]quinoline-1-thione Derivatives and Their Application as Protein Kinase Inhibitors
Published in Molecules (Basel, Switzerland) (01-07-2022)“…This study represents the design and synthesis of a new set of hybrid and chimeric derivatives of…”
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2
Recyclization of Maleimides by Binucleophiles as a General Approach for Building Hydrogenated Heterocyclic Systems
Published in Molecules (Basel, Switzerland) (18-08-2022)“…The building of heterocyclic systems containing hydrogenated fragments is an important step towards the creation of biologically-active compounds with a wide…”
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3
New Aspects of the Reaction of Thioacetamide and N-Substituted Maleimides
Published in Molecules (Basel, Switzerland) (01-12-2022)“…N-Arylmaleimides are universal substrates for the synthesis of various heterocyclic compounds with a wide spectrum of biological activity. However, their…”
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4
New Chemicals Suppressing SARS-CoV-2 Replication in Cell Culture
Published in Molecules (Basel, Switzerland) (01-09-2022)“…Candidates to being inhibitors of the main protease (Mpro) of SARS-CoV-2 were selected from the database of Voronezh State University using molecular modeling…”
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5
Characterization of adsorption of 5-carboxy-3-amino-1,2,4-triazole towards copper corrosion prevention in neutral media
Published in Electrochimica acta (10-06-2019)“…Adsorption behavior of 5-carboxy-3-amino-1,2,4-triazole (COOH-ATA) on copper in neutral (pH 7.4) borate buffer solutions with and without 0.01 M NaCl was…”
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6
Design, Synthesis, and Evaluation of New Hybrid Derivatives of 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one as Potential Dual Inhibitors of Blood Coagulation Factors Xa and XIa
Published in Molecules (Basel, Switzerland) (01-01-2024)“…Cardiovascular diseases caused by blood coagulation system disorders are one of the leading causes of morbidity and mortality in the world. Research shows that…”
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New Hybrid Tetrahydropyrrolo[3,2,1- ij ]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation
Published in Molecules (Basel, Switzerland) (01-05-2023)“…Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of…”
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6-Hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline Demonstrates Neuroprotective Properties in Experimental Parkinson's Disease by Enhancing the Antioxidant System, Normalising Chaperone Activity and Suppressing Apoptosis
Published in Neurochemical research (01-05-2024)“…Parkinson's disease (PD) is a neurodegenerative disease, whereby disturbances within the antioxidant defence system, increased aggregation of proteins, and…”
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9
New Blood Coagulation Factor XIIa Inhibitors: Molecular Modeling, Synthesis, and Experimental Confirmation
Published in Molecules (Basel, Switzerland) (12-02-2022)“…In the modern world, complications caused by disorders in the blood coagulation system are found in almost all areas of medicine. Thus, the development of new,…”
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10
6-Hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline Demonstrates Anti-Inflammatory Properties and Reduces Oxidative Stress in Acetaminophen-Induced Liver Injury in Rats
Published in Current issues in molecular biology (01-10-2023)“…We examined the effects of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline on markers of liver injury, oxidative status, and the extent of inflammatory and…”
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11
6-Hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline Alleviates Oxidative Stress and NF-κB-Mediated Inflammation in Rats with Experimental Parkinson’s Disease
Published in Current issues in molecular biology (01-09-2023)“…A study was conducted to investigate the effects of different doses of 6-hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline (HTHQ) on motor coordination…”
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12
Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1- ij ]Quinolin-2(1 H )-one as New Inhibitors of Factor Xa and Factor XIa
Published in Molecules (Basel, Switzerland) (19-04-2020)“…Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets for treatment for thrombotic disorders and thereby their…”
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13
A Multifield Study on Dimethyl Acetylenedicarboxylate: A Reagent Able to Build a New Cycle on Diaminoimidazoles
Published in Molecules (Basel, Switzerland) (22-05-2022)“…A new effective method for the synthesis of imidazo[1,5- ]pyridazines derivatives (yields = 68-89%) by the interaction of 1,2-diamino-4-phenylimidazole with…”
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14
Appendix A. dithioloquinolinethiones as new potential multitargeted antibacterial and antifungal agents: Synthesis, biological evaluation and molecular docking studies
Published in European journal of medicinal chemistry (01-08-2019)“…Herein we report the design, synthesis, molecular docking study and evaluation of antimicrobial activity of ten new dithioloquinolinethiones. The structures of…”
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15
A Study of the Peculiarities of the Formation of a Hybrid Interface Based on Polydopamine between Dental Tissues and Dental Composites, Using IR and Raman Microspectroscopy, at the Submicron Level
Published in International journal of molecular sciences (19-07-2023)“…The creation of buffer (hybrid) layers that provide improved adhesion to two heterogeneous materials is a promising and high-priority research area in the…”
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16
Azo-coupling of pyrazole-3(5)-diazonium chlorides with cyanothioacetamide: a convenient synthesis of pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides
Published in Tetrahedron letters (05-02-2014)“…Cyanothioacetamide reacts with pyrazole-3(5)-diazonium chlorides to afford pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides 5. The latter can be oxidized with…”
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17
Inhibition of Brass (80/20) by 5-Mercaptopentyl-3-Amino-1,2,4-Triazole in Neutral Solutions
Published in Metals (Basel ) (09-11-2017)“…The effect of the adsorption of 5-mercaptopentyl-3-amino-1,2,4-triazole (MPATA) on the corrosive behavior of brass (Cu80/Zn20) in neutral (pH 7.4) borate…”
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18
A novel synthetic approach to hydroimidazo[1,5- b ]pyridazines by the recyclization of itaconimides and HPLC-HRMS monitoring of the reaction pathway
Published in Beilstein journal of organic chemistry (30-11-2017)“…The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-…”
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19
Fabrication and Characterization of Thin Metal Films Deposited by Electroless Plating with Organic Additives for Electrical Circuits Applications
Published in Micromachines (Basel) (29-05-2023)“…In our work, we studied thin nickel films deposited by electroless plating for use as a barrier and seed layer in the through-silicon vias (TSV) technology…”
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20
Analysis of the spectral‐luminescence properties of imidazo[1,2‐b]pyrido[4,3‐e][1,2,4]triazin‐6(7Н)‐ones
Published in Luminescence (Chichester, England) (01-10-2022)“…The article presents a method for the construction of a new tricyclic system of imidazo[1,2‐b]pyrido[4,3‐e][1,2,4]triazin‐6(7Н)‐ones based on subsequent…”
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