Search Results - "Shiina, Yasuhiro"
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Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436
Published in Bioorganic & medicinal chemistry (01-07-2015)“…[Display omitted] We synthesized several biaryl derivatives as PDE10A inhibitors to prevent phototoxicity of…”
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Journal Article -
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Asymmetric Total Synthesis of Glycinoeclepin A: Generation of a Novel Bridgehead Anion Species
Published in Chemistry letters (05-08-2010)“…The asymmetric total synthesis of glycinoeclepin A, a hatch-stimulating agent of the soybean cyst nematode, was accomplished on the basis of a cyclopentene…”
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Journal Article -
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Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition
Published in Bioorganic & medicinal chemistry (15-01-2015)“…[Display omitted] A novel class of phosphodiesterase 10A inhibitors with potent PDE10A inhibitory activity and reduced CYP3A4 inhibition was designed and…”
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Journal Article -
4
Asymmetric Total Synthesis of Glycinoeclepin A
Published in Chemistry letters (01-08-2010)“…The asymmetric total synthesis of glycinoeclepin A, a hatch-stimulating agent of the soybean cyst nematode, was accomplished on the basis of a cyclopentene…”
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Journal Article -
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A Novel Cyclopentene Annulation Method Based on Conjugate Addition Reactions of α-Cyano Carbanion Species
Published in European Journal of Organic Chemistry (01-01-2006)“…A new cyclopentene annulation method based on a conjugate addition reaction with 4‐methoxybut‐3‐enenitrile was developed. Treatment of a cyclic enone with the…”
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