Search Results - "Shih, Joe"

Abstract 2096: Bozitinib, a highly selective inhibitor of cMet, demonstrates robust activity in gastric, lung, hepatic and pancreatic in vivo models by Shih, Joe, Zhong, Boyu, Shi, Hepeng, Xue, David, Choy, Gavin S., Redkar, Sanjeev

“…Background: cMET is a receptor tyrosine kinase that is located on the cell surface and is activated by the binding of its ligand, hepatocyte growth factor…”
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BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy by Chen, Yun-Yu, Lo, Chen-Fu, Chiu, Tai-Yu, Hsu, Chia-Yu, Yeh, Teng-Kuang, Chen, Ching-Ping, Huang, Chen-Lung, Huang, Chung-Yu, Wang, Min-Hsien, Huang, Yu-Chen, Ho, Hsuan-Hui, Chao, Yu-Sheng, Shih, Joe C., Tsou, Lun K., Chen, Chiung-Tong

“…Zinc(II)-dipicolylamine (Zn-DPA) has been shown to specifically identify and bind to phosphatidylserine (PS), which exists in bulk in the tumor…”
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Atorvastatin and Celecoxib Inhibit Prostate PC-3 Tumors in Immunodeficient Mice by XI ZHENG, CUI, Xiao-Xing, RABSON, Arnold B, REDDY, Bandaru S, CONNEY, Allan H, AVILA, Gina E, HUANG, Mou-Tuan, YUE LIU, PATEL, Jagruti, KONG, Ah Ng Tony, PAULINE, Raphael, JOE SHIH, Weichung, YONG LIN

“…Purpose: To investigate the effects and mechanisms of atorvastatin and celecoxib administered individually or in combination on human prostate cancer PC-3…”
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Effects of soybean lipid infusion on triglyceride and unbound free fatty acid levels in preterm infants by Hegyi, Thomas, Kleinfeld, Alan, Huber, Andrew, Weinberger, Barry, Memon, Naureen, Joe Shih, Weichung, Carayannopoulos, Mary, Oh, William

“…Objective: To determine the plasma triglyceride (TG) and unbound free fatty acid (FFAu) levels in infants treated with increasing dosages of soybean lipid,…”
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Empirical shrinkage estimator for consistency assessment of treatment effects in multi-regional clinical trials by Quan, Hui, Li, Mingyu, Shih, Weichung Joe, Ouyang, Soo Peter, Chen, Joshua, Zhang, Ji, Zhao, Peng-Liang

“…Multi‐regional clinical trials have been widely used for efficient global new drug developments. Both a fixed‐effect model and a random‐effect model can be…”
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Methods for flexible sample-size design in clinical trials: Likelihood, weighted, dual test, and promising zone approaches by Shih, Weichung Joe, Li, Gang, Wang, Yining

“…Abstract Sample size plays a crucial role in clinical trials. Flexible sample-size designs, as part of the more general category of adaptive designs that…”
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Heart rate variability biofeedback increases baroreflex gain and peak expiratory flow by Lehrer, Paul M, Vaschillo, Evgeny, Vaschillo, Bronya, Lu, Shou-En, Eckberg, Dwain L, Edelberg, Robert, Shih, Weichung Joe, Lin, Yong, Kuusela, Tom A, Tahvanainen, Kari U O, Hamer, Robert M

“…We evaluated heart rate variability biofeedback as a method for increasing vagal baroreflex gain and improving pulmonary function among 54 healthy adults. We…”
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A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors by DING, NING, CUI, XIAO-XING, GAO, ZHI, HUANG, HUARONG, WEI, XINGCHUAN, DU, ZHIYUN, LIN, YONG, SHIH, WEICHUNG JOE, RABSON, ARNOLD B, CONNEY, ALLAN H, HU, CHUNHONG, ZHENG, XI

“…Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority of pancreatic cancer patients, an approach to inhibit the…”
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A Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19 by Liu, Wang-Da, Feng, Po-Hao, Cheng, Chien-Yu, Chou, Chun-Liang, Lee, Chih-Hsin, Lu, Min-Chi, Liu, Po-Yu, Lee, Mei-Hui, Liao, Chun-Hsing, Chen, Mei-Chuan, Chen, Cheng-Pin, Hsu, Shang-Fu, Tzeng, Yu-Tien, Lin, Yi-Chun, Ou, Tsong-Yih, Qin, Albert, Tsai, Chan-Yen, Shih, Weichung Joe, Lee, Kang-Yun, Sheng, Wang-Huei

“…Introduction Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of…”
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Expression genomics of cervical cancer: Molecular classification and prediction of radiotherapy response by DNA microarray by YICK FU WONG, SELVANAYAGAM, Zachariah E, WING KIT LO, Keith, SO FAN YIM, SHING KAI YIP, TSE NGONG, Danny, SIU, Nelson, KIT YING CHAN, Loucia, CHUN SING CHAN, KONG, Tony, KUTLINA, Elena, MCKINNON, Randall D, NIEN WEI, DENHARDT, David T, CHIN, Khew-Voon, KWOK HUNG CHUNG, Tony, PORTER, Joseph, VITTAL, Ragini, RONG HU, YONG LIN, LIAO, Jason, WEICHUNG SHIH, Joe, TAK HONG CHEUNG

“…The incidence and mortality rates of cervical cancer are declining in the United States; however, worldwide, cervical cancer is still one of the leading causes…”
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Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice by Lou, You-Rong, Peng, Qing-Yun, Li, Tao, Medvecky, Christopher M., Lin, Yong, Shih, Weichung Joe, Conney, Allan H., Shapses, Sue, Wagner, George C., Lu, Yao-Ping

“…Our previous studies reported that caffeine or voluntary exercise decreased skin tumor multiplicity, in part, by decreasing fat levels in the dermis. These…”
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Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet by Lu, Yao-Ping, Lou, You-Rong, Bernard, Jamie J., Peng, Qing-Yun, Li, Tao, Lin, Yong, Shih, Weichung Joe, Nghiem, Paul, Shapses, Sue, Wagner, George C., Conney, Allan H.

“…Removal of the parametrial fat pads (partial lipectomy) from female SKH-1 mice fed a high-fat diet inhibited UVB-induced carcinogenesis, but this was not…”
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Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence by Zheng, Xi, Cui, Xiao-Xing, Gao, Zhi, Zhao, Yang, Lin, Yong, Shih, Weichung Joe, Huang, Mou-Tuan, Liu, Yue, Rabson, Arnold, Reddy, Bandaru, Yang, Chung S, Conney, Allan H

“…Epidemiology studies suggest that statins and nonsteroidal anti-inflammatory drugs reduce the risk of prostate cancer. In the present study, LNCaP cells were…”
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Oral Administration of a Gemini Vitamin D Analog, a Synthetic Triterpenoid and the Combination Prevents Mammary Tumorigenesis Driven by ErbB2 Overexpression by JAE YOUNG SO, WAHLER, Joseph E, NANJOO SUH, TAESOOK YOON, SMOLAREK, Amanda K, YONG LIN, WEICHUNG JOE SHIH, MAEHR, Hubert, USKOKOVIC, Milan, LIBY, Karen T, SPORN, Michael B

“…HER2 (or ErbB2), a member of ErbB receptor tyrosine kinases, is overexpressed in approximately 20% of human breast cancer, and the ErbB2 signaling pathway is a…”
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A mixture model for estimating the local false discovery rate in DNA microarray analysis by Liao, J.G., Lin, Yong, Selvanayagam, Zachariah E., Shih, Weichung Joe

“…Motivation: Statistical methods based on controlling the false discovery rate (FDR) or positive false discovery rate (pFDR) are now well established in…”
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Disruption of the EF-2 kinase/Hsp90 protein complex : A possible mechanism to inhibit glioblastoma by geldanamycin by JUN YANG, YANG, Jin-Ming, IANNONE, Marie, WEICHUNG JOE SHIH, YONG LIN, HAIT, William N

“…Glioblastoma multiforme is the most treatment-resistant brain tumor. Elongation factor-2 (EF-2) kinase (calmodulin kinase III) is a unique protein kinase that…”
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Effects of Soybean Lipid Infusion on Unbound Free Fatty Acids and Unbound Bilirubin in Preterm Infants by Hegyi, Thomas, MD, Kleinfeld, Alan, PhD, Huber, Andrew, PhD, Weinberger, Barry, MD, Memon, Naureen, MD, Shih, Weichung Joe, PhD, Carayannopoulos, Mary, PhD, Oh, William, MD

“…Objective To assess the effects of a soybean lipid emulsion infusions on levels of unbound (free) bilirubin (Bf) and unbound free fatty acids (FFAu) as well as…”
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Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice by Avila, Gina E, Zheng, Xi, Cui, Xiao Xing, Ryan, Amanda D, Hansson, Annette, Suh, Junghan, Rabson, Arnold B, Chang, Richard L, Shih, Weichung Joe, Lin, Yong, Crowell, Pamela, Lu, Yao Ping, Lou, You Rong, Conney, Allan H

“…Treatment of cultured PANC-1, MIA PaCa-2, and BxPC-3 human pancreatic adenocarcinoma cells with 0.1 to 1.6 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 96…”
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Multi-regional clinical trial design and consistency assessment of treatment effects by Quan, Hui, Mao, Xuezhou, Chen, Joshua, Shih, Weichung Joe, Ouyang, Soo Peter, Zhang, Ji, Zhao, Peng-Liang, Binkowitz, Bruce

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Group sequential, sample size re-estimation and two-stage adaptive designs in clinical trials: a comparison by Shih, Weichung Joe

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