Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment

Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment

IntroductionEpidemiological evidence suggests that both poor cardiovascular fitness and low muscle mass or strength markedly increase the rate of cognitive decline and incident dementia in older adults. Results from exercise trials for the improvement of cognition in older adults with mild cognitive...

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Published in:BMJ open Vol. 12; no. 12; p. e062059
Main Authors: Valenzuela, Trinidad, Coombes, Jeff S, Liu-Ambrose, Teresa, Mavros, Yorgi, Kochan, Nicole, Sachdev, Perminder S, Hausdorff, Jeffrey, Smith, Emily C, Hollings, Matthew, Hawkins, Tess C, Ashley, Nicholas J, Feter, Natan, Wilson, Guy C, Shih, Isabel Hui En, Guerrero, Yareni, Jiang, Jiyang, Wen, Wei, Bailey, Tom, Stensvold, Dorthe, Wisløff, Ulrik, Falck, Ryan S, Fiatarone Singh, Maria
Format: Journal Article
Language:English
Published: England British Medical Journal Publishing Group 20-12-2022
BMJ Publishing Group LTD
BMJ Publishing Group
Series:Protocol
Subjects:
Aerobics
Aged
Australia
Biomarkers
Body composition
Clinical trials
Cognition & reasoning
Cognition - physiology
Cognitive ability
Cognitive Dysfunction - psychology
Cognitive Training
Dementia
Executive function
Exercise
Exercise Therapy - methods
GERIATRIC MEDICINE
Humans
Insulin
Insulin-like growth factors
Interval training
Intervention
Morphology
Nutritional status
Older people
Pathology
Physical fitness
Physiology
Quality of life
Randomized Controlled Trials as Topic
Resistance Training - methods
Sports and Exercise Medicine
SPORTS MEDICINE
Strength training
Australia
Canada
SPORTS MEDICINE
GERIATRIC MEDICINE
Dementia
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Summary:IntroductionEpidemiological evidence suggests that both poor cardiovascular fitness and low muscle mass or strength markedly increase the rate of cognitive decline and incident dementia in older adults. Results from exercise trials for the improvement of cognition in older adults with mild cognitive impairment (MCI) have reported mixed results. This is possibly due to insufficient exercise intensities. The aim of the Balance, Resistance, And INterval (BRAIN) Training Trial is to determine the effects of two forms of exercise, high-intensity aerobic interval training (HIIT) and high-intensity power training (POWER) each compared with a sham exercise control group on cognition in older adults with MCI.Methods and analysisOne hundred and sixty community-dwelling older (≥ 60 years) people with MCI have been randomised into the trial. Interventions are delivered supervised 2–3 days per week for 12 months. The primary outcome measured at baseline, 6 and 12 months is performance on a cognitive composite score measuring the executive domain calculated from a combination of computerised (NeuroTrax) and paper-and-pencil tests. Analyses will be performed via repeated measures linear mixed models and generalised linear mixed models of baseline, 6-month and 12-month time points, adjusted for baseline values and covariates selected a priori. Mixed models will be constructed to determine the interaction of GROUP × TIME.Ethics and disseminationEthical approval was obtained from the University of Sydney (HREC Ref.2017/368), University of Queensland (HREC Ref. 2017/HE000853), University of British Columbia (H16-03309), and Vancouver Coastal Health Research Institute (V16-03309) Human Research Ethics. Dissemination will be via publications, conference presentations, newsletter articles, social media, talks to clinicians and consumers and meetings with health departments/managers.It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT and POWER on subclinical markers of disease.Trial registration numberACTRN12617001440314 Australian New Zealand Clinical Trials Registry.
Bibliography:Protocol
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ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-062059