Search Results - "Shih, David JH"
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Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
Published in Acta neuropathologica (01-04-2012)“…The diagnosis of medulloblastoma likely encompasses several distinct entities, with recent evidence for the existence of at least four unique molecular…”
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Clonal selection drives genetic divergence of metastatic medulloblastoma
Published in Nature (London) (23-02-2012)“…In a mouse model and in human medulloblastoma patients, the metastases in an individual have similar genomic alterations and DNA methylation patterns, but…”
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Spatial heterogeneity in medulloblastoma
Published in Nature genetics (01-05-2017)“…Michael Taylor, Marco Marra and colleagues analyze spatial tumor heterogeneity in 9 medulloblastomas, 16 high-grade gliomas and 10 renal cell carcinomas, using…”
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A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases
Published in Cell (22-02-2018)“…While the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to…”
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Biomolecular Condensation: A New Phase in Cancer Research
Published in Cancer discovery (02-09-2022)“…Multicellularity was a watershed development in evolution. However, it also meant that individual cells could escape regulatory mechanisms that restrict…”
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Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup: An Integrated Clinical and Molecular Analysis
Published in The lancet oncology (12-03-2016)Get full text
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WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma
Published in Acta neuropathologica communications (24-12-2014)“…TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved…”
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