Search Results - "Shih, D T"

Combining Digital Archives Content with Serious Game Approach to Create a Gamified Learning Experience by Shih, D.-T., Lin, C. L., Tseng, C.-Y.

“…This paper presents an interdisciplinary to develop content-aware application that combines game with learning on specific categories of digital archives. The…”
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Functional role of the distal valine (E11) residue of alpha subunits in human haemoglobin by Tame, J, Shih, D T, Pagnier, J, Fermi, G, Nagai, K

“…We have expressed human alpha-globin to a high level in Escherichia coli as a fusion protein, purified it and removed the N-terminal leader sequence by…”
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The chloride effect in human haemoglobin. A new kind of allosteric mechanism by Perutz, M F, Shih, D T, Williamson, D

“…Chloride reduces the oxygen affinity of mammalian haemoglobin by acting as an allosteric effector that stabilizes the quaternary deoxy (T) structure. Perutz…”
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Involvement of the distal histidine in the low affinity exhibited by Hb Chico (Lys beta 66----Thr) and its isolated beta chains by BONAVENTURA, C, CASHON, R, BONAVENTURA, J, PERUTZ, M, FERMI, G, SHIH, D. T.-B

“…Hemoglobin (Hb) Chico (Lys beta 66---Thr at E10) has a diminished oxygen affinity (Shih, D. T.-b., Jones, R. T., Shih, M. F.-C., Jones, M. B., Koler, R. D.,…”
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EGF-R dependent regulation of keratinocyte survival by Rodeck, U, Jost, M, Kari, C, Shih, D T, Lavker, R M, Ewert, D L, Jensen, P J

“…Tissue organization and maintenance within multicellular organisms is in part dependent on the ability of cells to undergo programmed cell death or apoptosis…”
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Site-directed mutagenesis in haemoglobin. Functional role of tyrosine-42(C7) alpha at the alpha 1-beta 2 interface by Imai, K, Fushitani, K, Miyazaki, G, Ishimori, K, Kitagawa, T, Wada, Y, Morimoto, H, Morishima, I, Shih, D T, Tame, J

“…To clarify the functional role of Tyr-42(C7) alpha, which forms a hydrogen bond with Asp-99(G1) beta at the alpha 1-beta 2 interface of human deoxyhaemoglobin,…”
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Structure and Function of Human Hemoglobin Covalently Labeled with Periodate-oxidized Adenosine Triphosphate by Kavanaugh, M P, Perutz, M F, Fermi, G, Shih, D T, Jones, R T

“…Periodate-oxidized adenosine triphosphate (o-ATP), a ribose ring-opened dialdehyde derivative of ATP, reacts specifically with human deoxyhemoglobin to give a…”
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Hb Long Island: a hemoglobin variant with a methionyl extension at the NH2 terminus and a prolyl substitution for the normal histidyl residue 2 of the beta chain by BARWICK, R. C, JONES, R. T, HEAD, C. G, SHIH, M. F.-C, PRCHAL, J. T, SHIH, D. T.-B

“…Hb Long Island was found in a diabetic man and his nondiabetic mother as the result of a routine clinical measurement of Hb AIc. It is present in amounts…”
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Was the loss of the D helix in α globin a functionally neutral mutation? by Komiyama, Noboru H, Shih, Daniel T.-B, Looker, Doug, Tame, Jeremy, Nagai, Kiyoshi

“…Proteins in the globin family are found in a variety of species from bacteria to man. From the many globin sequences known, evolutionary trees have been…”
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Involvement of Glu G3(101)beta in the function of hemoglobin. Comparative O2 equilibrium studies of human mutant hemoglobins by Shih, D T, Jones, R T, Imai, K, Tyuma, I

“…The glutamyl residue at G3(101)beta of normal hemoglobin (Hb A) is one of the alpha 1 beta 2 subunit contacts which are vital to O2 binding properties of the…”
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A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function by Woska, Joseph R., Shih, Daw‐tsun, Taqueti, Viviany R., Hogg, Nancy, Kelly, Terence A., Kishimoto, Takashi K.

“…Lymphocyte function‐associated antigen(LFA)‐1/intercellular adhesion molecule (ICAM)‐1interactions mediate several important steps in the evolution of animmune…”
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Epitopes of adhesion-perturbing monoclonal antibodies map within a predicted alpha-helical domain of the integrin beta 1 subunit by Shih, D T, Boettiger, D, Buck, C A

“…Several recent studies have demonstrated the involvement of various domains of the beta 1 integrin subunit in ligand binding. Thus, specific amino acids have…”
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Vitreous-induced Modulation of Integrins in Retinal Pigment Epithelial Cells: Effects of Fibroblast Growth Factor-2 by Meitinger, Daniela, Hunt, D.Margaret, Shih, Daw-tsun, Fox, Jonathan C, Hunt, Richard C

“…Growth in the presence of vitreous results in transformation of human RPE cells from an epithelioid to a fibroblast-like appearance and leads to an elevation…”
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Cross-linking hemoglobin by design: lessons from using molecular clamps by Kluger, R, Jones, R T, Shih, D T

“…The development of a red cell substitute by chemical modification of hemoglobin has been approached as a systematic, iterative process. Acyl phosphate methyl…”
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Modification of human hemoglobin with methyl acyl phosphates derived from dicarboxylic acids. Systematic relationships between cross-linked structure and oxygen-binding properties by Jones, Richard T, Head, Charlotte G, Fujita, Thomas S, Shih, Daniel T. B, Wodzinska, Jolanta, Kluger, Ronald

“…Human hemoglobin was reacted with five dicarboxylic acid bis(methyl phosphate) reagents under different ligand conditions. The bis(methyl phosphate) reagents…”
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Structure/Function Analysis of the Integrin β 1 Subunit by Epitope Mapping by Shih, Daw-Tsun, Edelman, Jonathan M., Horwitz, Alan F., Grunwald, Gerald B., Buck, Clayton A.

“…Monoclonal antibodies (mAbs) have been produced against the chicken β 1 subunit that affect integrin functions, including ligand binding, α subunit…”
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The pKa values of two histidine residues in human haemoglobin, the Bohr effect, and the dipole moments of alpha-helices by Perutz, M F, Gronenborn, A M, Clore, G M, Fogg, J H, Shih, D T

“…Studies of abnormal and chemically modified haemoglobins indicate that in 0.1 M-NaCl about 40% of the alkaline Bohr effect of human haemoglobin is contributed…”
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A doubly cross-linked human hemoglobin. Effects of cross-links between different subunits by Jones, R T, Shih, D T, Fujita, T S, Song, Y, Xiao, H, Head, C, Kluger, R

“…Human deoxyhemoglobin cross-linked with trimesyl tris(3,5-dibromosalicylate) produces the previously reported cross-linked hemoglobin in which the epsilon…”
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Hemoglobin Denver [alpha 2 beta 2(41) (C7) Phe-->Ser]: a low-O2-affinity variant associated with chronic cyanosis and anemia by Stabler, S P, Jones, R T, Head, C, Shih, D T, Fairbanks, V F

“…To report a previously undescribed low-O2-affinity hemoglobin variant that is associated with chronic cyanosis. Pertinent laboratory and historical data for…”
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Influence of anions and protons on the Adair coefficients of haemoglobins A and Cowtown (His HC3(146) beta----Leu) by Shih, D T, Perutz, M F

“…We have measured the contribution of the alkaline Bohr effect of the C-terminal histidine residues of the beta-chains of haemoglobin A by comparing haemoglobin…”
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