Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium

Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium

Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E ( 1 – 5 ) and two new coumarins, caloforines F and G ( 6 and 7 ). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their abso...

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Bibliographic Details
Published in:Journal of natural medicines Vol. 76; no. 3; pp. 645 - 653
Main Authors: Ogasawara, Ai, Noguchi, Ryo, Shigi, Takuya, Nugroho, Alfarius Eko, Hirasawa, Yusuke, Kaneda, Toshio, Tougan, Takahiro, Horii, Toshihiro, Hadi, A. Hamid A., Morita, Hiroshi
Format: Journal Article
Language:English
Published: Singapore Springer Nature Singapore 01-06-2022
Springer Nature B.V
Subjects:
Antimalarial activity
Antimalarial agents
Biological activity
Biomedical and Life Sciences
Biomedicine
Calophyllum
Complementary & Alternative Medicine
Flowers & plants
Magnetic resonance spectroscopy
Medicinal Chemistry
NMR
Nuclear magnetic resonance
Original Paper
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Sciences
Spectrum analysis
Antimalarial activity
Pyranocoumarin
Coumarin
Caloforines A–G
Calophyllum scriblitifolium
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Summary:Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E ( 1 – 5 ) and two new coumarins, caloforines F and G ( 6 and 7 ). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A–F ( 1 – 6 ) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. Graphical abstract
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ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-022-01613-6