Search Results - "Shigesada, Naoya"

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models by Morita, Maaya, Yoneda, Aki, Tokunoh, Nagisa, Masaki, Tatsumi, Shirakura, Keisuke, Kinoshita, Mayumi, Hashimoto, Rina, Shigesada, Naoya, Takahashi, Junya, Tachibana, Masashi, Tanaka, Shota, Obana, Masanori, Hino, Nobumasa, Ikawa, Masahito, Tsujikawa, Kazutake, Ono, Chikako, Matsuura, Yoshiharu, Kidoya, Hiroyasu, Takakura, Nobuyuki, Kubota, Yoshiaki, Doi, Takefumi, Takayama, Kazuo, Yoshioka, Yasuo, Fujio, Yasushi, Okada, Yoshiaki

“…There is an urgent need to develop novel drugs to reduce the mortality from severe infectious diseases with the emergence of new pathogens, including…”
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Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation by Shirakura, Keisuke, Ishiba, Ryosuke, Kashio, Taito, Sakai, Miki, Fukushima, Yu, Yamamoto, Nana, Manabe, Shiori, Shigesada, Naoya, Tanaka, Toru, Hino, Nobumasa, Aird, William C., Doi, Takefumi, Okada, Yoshiaki

“…Roundabout4 (Robo4) is an endothelial cell-specific receptor that stabilizes vasculature in pathological angiogenesis. Previous studies have shown that Robo4…”
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Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice by Yamamoto, Tsuyoshi, Fujii, Naoko, Yasuhara, Hidenori, Wada, Shunsuke, Wada, Fumito, Shigesada, Naoya, Harada-Shiba, Mariko, Obika, Satoshi

“…The multiple-turnover ability of a series of locked nucleic acid (LNA)-based antisense oligonucleotides (AONs) in the RNase H-mediated scission reaction was…”
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Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration by Shigesada, Naoya, Shikada, Naoya, Shirai, Manabu, Toriyama, Michinori, Higashijima, Fumiaki, Kimura, Kazuhiro, Kondo, Toru, Bessho, Yasumasa, Shinozuka, Takuma, Sasai, Noriaki

“…Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction, affecting 1 in 4000 people worldwide. This disease is currently assumed…”
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