Search Results - "Shigeru OHTA"

Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures by Yokoyama, Yuichi, Sasaki, Yoshifumi, Terasaki, Natsuko, Kawataki, Taku, Takekawa, Koji, Iwase, Yumiko, Shimizu, Toshinobu, Sanoh, Seigo, Ohta, Shigeru

“…Differentiated HepaRG cells maintain liver-specific functions such as drug-metabolizing enzymes. In this study, the feasibility of HepaRG cells as a human…”
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Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery by Naritomi, Yoichi, Sanoh, Seigo, Ohta, Shigeru

“…Predicting human drug metabolism and pharmacokinetics (PK) is key to drug discovery. In particular, it is important to predict human PK, metabolite profiles…”
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Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro–in Vivo Extrapolation and Allometric Scaling by Naritomi, Yoichi, Sanoh, Seigo, Ohta, Shigeru

“…Predicting human pharmacokinetics (PK) such as clearance (CL) and volume of distribution (Vd) is a critical component of drug discovery. These predictions are…”
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Purification of monoclonal antibodies entirely in flow-through mode by Yamada, Tsuyoshi, Yamamoto, Koichi, Ishihara, Takashi, Ohta, Shigeru

“…•An antibody purification process entirely in flow-through mode was achieved.•Buffer exchange improved the impurity clearance by depth filtration.•A…”
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Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity by Watanabe, Yoko, Kojima, Hiroyuki, Takeuchi, Shinji, Uramaru, Naoto, Sanoh, Seigo, Sugihara, Kazumi, Kitamura, Shigeyuki, Ohta, Shigeru

“…Benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is widely used as sunscreen for protection of human skin and hair from damage by ultraviolet (UV)…”
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Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons by Ishida, Keishi, Kotake, Yaichiro, Sanoh, Seigo, Ohta, Shigeru

“…Lead is a persistent environmental pollutant and exposure to high environmental levels causes various deleterious toxicities, especially to the central nervous…”
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Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity‐independent mechanism by Miyara, Masatsugu, Kotake, Yaichiro, Tokunaga, Wataru, Sanoh, Seigo, Ohta, Shigeru

“…Parkinson's disease (PD) is the second most common neurodegenerative disorder, but its underlying cause remains unknown. Although recent studies using…”
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Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons by Ishida, Keishi, Takeda, Kazuki, Takehara, Yuki, Takabayashi, Tomoki, Miyara, Masatsugu, Sanoh, Seigo, Kawai, Hidehiko, Ohta, Shigeru, Kotake, Yaichiro

“…Methylmercury (MeHg) is a well-known environmental pollutant that has harmful effects on the central nervous systems of humans and animals. The molecular…”
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Drug-Metabolizing Ability of Molybdenum Hydroxylases by Kitamura, Shigeyuki, Sugihara, Kazumi, Ohta, Shigeru

“…Molybdenum hydroxylases, which include aldehyde oxidase and xanthine oxidoreductase, are involved in the metabolism of some medicines in humans. They exhibit…”
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Design, Synthesis, and Pharmacological Activity of Nonallergenic Pyrazolone-Type Antipyretic Analgesics by Uramaru, Naoto, Shigematsu, Hidenari, Toda, Akihisa, Eyanagi, Reiko, Kitamura, Shigeyuki, Ohta, Shigeru

“…To develop novel nonallergenic pyrazolone analgesics, we synthesized a series of compounds in which position 1 of the pyrazolone ring was substituted in place…”
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Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy by Fujino, Chieri, Sanoh, Seigo, Tateno, Chise, Ohta, Shigeru, Kotake, Yaichiro

“…Liver resection is performed to remove tumors in patients with liver cancer, but the procedure's suitability depends on the regenerative ability of the liver…”
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Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays by Sato, Koya, Sanoh, Seigo, Ishida, Yuji, Tateno, Chise, Ohta, Shigeru, Kotake, Yaichiro

“…Felbamate (FBM) is an antiepileptic drug that has minimal toxicity in preclinical toxicological species but has a serious idiosyncratic drug toxicity (IDT) in…”
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Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy by Sanoh, Seigo, Tayama, Yoshitaka, Sugihara, Kazumi, Kitamura, Shigeyuki, Ohta, Shigeru

“…Aldehyde oxidase contributes to drug metabolism and pharmacokinetics (PK), and a few clinical studies were discontinued because of aldehyde oxidase metabolism…”
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Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver by Sanoh, Seigo, Tamura, Yuka, Fujino, Chieri, Sugahara, Go, Yoshizane, Yasumi, Yanagi, Ami, Kisoh, Keishi, Ishida, Yuji, Tateno, Chise, Ohta, Shigeru, Kotake, Yaichiro

“…Drug-induced liver injury (DILI) is a common side effect of several medications and is considered a major factor responsible for the discontinuation of drugs…”
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New Series of Antiprion Compounds:  Pyrazolone Derivatives Have the Potent Activity of Inhibiting Protease-Resistant Prion Protein Accumulation by Kimata, Ayako, Nakagawa, Hidehiko, Ohyama, Ryo, Fukuuchi, Tomoko, Ohta, Shigeru, Suzuki, Takayoshi, Miyata, Naoki

“…To find effective antiprion compounds, we synthesized and evaluated various pyrazolone derivatives. Seven of 19 compounds showed inhibition of PrP-res…”
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Comparative study of hydrolytic metabolism of dimethyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate by microsomes of various rat tissues by Ozaki, Hitomi, Sugihara, Kazumi, Watanabe, Yoko, Moriguchi, Kyoko, Uramaru, Naoto, Sone, Tomomichi, Ohta, Shigeru, Kitamura, Shigeyuki

“…Phthalates are used in food packaging, and are transferred to foods as contaminants. In this study, we examined the hydrolytic metabolism of dimethyl phthalate…”
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Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation by Kawabata, Kohei, Sugihara, Kazumi, Sanoh, Seigo, Kitamura, Shigeyuki, Ohta, Shigeru

“…In order to investigate the effect of sunlight on the persistence and ecotoxicity of pharmaceuticals contaminating the aquatic environment, we exposed nine…”
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Mild MPP+ exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation by Sakamoto, Shuichiro, Miyara, Masatsugu, Sanoh, Seigo, Ohta, Shigeru, Kotake, Yaichiro

“…Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, mainly characterised by the progressive loss of dopaminergic neurons. MPP + has been widely…”
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Cytochrome P450-inhibitory activity of parabens and phthalates used in consumer products by Ozaki, Hitomi, Sugihara, Kazumi, Watanabe, Yoko, Ohta, Shigeru, Kitamura, Shigeyuki

“…The in vitro cytochrome P450 (CYP)-inhibitory effects of 11 parabens and 7 phthalates used in consumer products, as well as their hydrolytic metabolites, were…”
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Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats by Tayama, Yoshitaka, Sugihara, Kazumi, Sanoh, Seigo, Miyake, Katsushi, Kitamura, Shigeyuki, Ohta, Shigeru

“…Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and…”
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