Search Results - "Shigeru Kotake"

Serum levels of galectin-3 in idiopathic inflammatory myopathies: a potential biomarker of disease activity by Watanabe, Eri, Kato, Kazunori, Gono, Takahisa, Chiba, Emiko, Terai, Chihiro, Kotake, Shigeru

“…Abstract Objectives Galectin-3 is involved in various biological activities, including immune activations and fibrosis. Idiopathic inflammatory myopathies…”
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The Plasticity of Th17 Cells in the Pathogenesis of Rheumatoid Arthritis by Kotake, Shigeru, Yago, Toru, Kobashigawa, Tsuyoshi, Nanke, Yuki

“…Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). It has been revealed that Th17…”
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Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial ‘human osteoclastology’ by Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki

“…Many papers have reported that osteoclasts play an important role in the pathogenesis of rheumatoid arthritis (RA); however, when we started to investigate the…”
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IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats by Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Furuya, Takefumi, Kobashigawa, Tsuyoshi, Kamatani, Naoyuki, Kotake, Shigeru

“…This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from peripheral blood mononuclear cells (PBMC). Furthermore, in vivo…”
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IL-23 and Th17 Disease in Inflammatory Arthritis by Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Kobashigawa, Tsuyoshi, Yamanaka, Hisashi, Kotake, Shigeru

“…IL-23, which is composed of p19 and p40 subunits, is a proinflammatory cytokine that contributes to the formation and maintenance of Th17 cells in inflammatory…”
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Adult-onset Still’s disease during pregnancy that delivered a neonate with haemophagocytic lymphohistiocytosis and severe liver failure requiring liver transplantation: A case report and literature review by Watanabe, Eri, Sugiyama, Yohei, Sato, Hiroaki, Imanishi, Toshiyuki, Fukuda, Akinari, Takagi, Kenjiro, Asano, Tomoyuki, Migita, Kiyoshi, Nanki, Toshihiro, Kotake, Shigeru

“…Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown aetiology that is categorised as a non-hereditary disease. Neonatal…”
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Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts by Yamanaka, Hisashi, Kawamoto, Manabu, Yago, Toru, Kobashigawa, Tsuyoshi, Nanke, Yuki, Kotake, Shigeru

“…Objectives. Drug repositioning or drug reprofiling (DR) has recently been growing in importance. DR has a significant advantage over traditional drug…”
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Tonsillectomy to Effectively Treat a Patient with Behçet's Disease by Nanke, Yuki, Kobasigawa, Tsuyoshi, Yoda, Keiko, Yamanaka, Hisashi, Kotake, Shigeru

“…Behçet's disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. We herein report a 27-year-old woman who…”
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A case of psoriatic arthritis, with joint involvement preceding skin involvement, successfully treated with adalimumab (80 mg every other week) by Nanke, Yuki, Kobashigawa, Tsuyoshi, Sugimoto, Naoki, Yamanaka, Hisashi, Kotake, Shigeru

“…Here we present a 45-year-old male patient who suffered from psoriatic arthritis (PsA), for which adalimumab (80 mg every other week) was effective. Dose…”
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Four cases of HLA-A26(+)/B51(−) intestinal Behçet’s disease without abdominal symptoms by Kobashigawa, Tsuyoshi, Nanke, Yuki, Yamanaka, Hisashi, Kotake, Shigeru

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Tacrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Th17 differentiation by Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Yamanaka, Hisashi, Kotake, Shigeru

“…► Tacrolimus inhibited IL-17-induced osteoclastogenesis and Th17 differentiation. Tacrolimus (FK506, Prograf®) is an orally available, T cell specific and…”
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Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts by Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki

“…Fewer molecules have been identified on human than murine osteoclasts, the former differing from murine osteoclasts in many ways. We show that…”
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Spinal Tophaceous Gout by Kotake, Shigeru, Nanke, Yuki

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Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack by Nanke, Yuki, Kotake, Shigeru, Goto, Mari, Ujihara, Hiroshi, Matsubara, Masao, Kamatani, Naoyuki

“…The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD…”
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Granzyme B Induces Apoptosis of Chondrocytes with Natural Killer Cell-like Cytotoxicity in Rheumatoid Arthritis by SAITO, Seiji, MURAKOSHI, Kaoru, KOTAKE, Shigeru, KAMATANI, Naoyuki, TOMATSU, Taisuke

“…Objective Granzyme B, an apoptosis-inducing factor, is expressed in natural killer (NK) cells, an important factor in innate immunity. We previously reported…”
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Presence of anti-transcriptional intermediary factor-1 gamma antibodies in a dermatomyositis patient with retroperitoneal cancer of unknown primary site by Hori, Hiroshi, Ozeki, Yusuke, Kobashigawa, Tsuyoshi, Futsuhara, Kazusige, Tanaka, Akira, Watanabe, Eri, Yabe, Hiroki, Yago, Toru, Fukuchi, Takahiko, Sugawara, Hitoshi, Kotake, Shigeru

“…A 71-year-old woman with dermatomyositis (DM) received glucocorticoid steroid (GCS) and tacrolimus treatment. Relapse of skin symptoms was observed after…”
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A Case of Mikulicz's Disease, IgG4-related Plasmacytic Syndrome, Successfully Treated by Corticosteroid and Mizoribine, Followed by Mizoribine Alone by Nanke, Yuki, Kobashigawa, Tsuyoshi, Yago, Toru, Kamatani, Naoyuki, Kotake, Shigeru

“…We report a case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated with corticosteroid and mizoribine, followed by mizoribine…”
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"Possible Primary Antiphospholipid Syndrome" with Concurrent Diffuse Alveolar Hemorrhaging and Libman-Sacks Endocarditis Mimicking Catastrophic Antiphospholipid Syndrome by Suzuki, Akitake, Asazuma, Naoki, Kikuchi, Eigo, Kawanobe, Takeshi, Horimoto, Yoshihiko, Yokobari, Ryuichi, Kotake, Shigeru, Okai, Takahiro

“…Although antiphospholipid antibody syndrome (APS) is an autoimmune condition that is primarily characterized by arterial or venous thrombosis or pregnancy…”
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Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts - Crucial 'Human Osteoclastology' by Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki

“…Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported…”
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Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study by FURUYA, Takefumi, KOTAKE, Shigeru, HARA, Masako, TOMATSU, Taisuke, YAMANAKA, Hisashi, KAMATANI, Naoyuki, INOUE, Eisuke, NANKE, Yuki, YAGO, Toru, KOBASHIGAWA, Tsuyoshi, ICHIKAWA, Naomi, TANAKA, Eiichi, MOMOHARA, Shigeki, NAKAJIMA, Ayako

“…OBJECTIVE: To evaluate the association between potential risk factors and incident clinical fractures in Japanese patients with rheumatoid arthritis (RA)…”
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