Search Results - "Shigemura, Masahiko"

Effects of hypercapnia on the lung by Shigemura, Masahiko, Lecuona, Emilia, Sznajder, Jacob I.

“…Gases are sensed by lung cells and can activate specific intracellular signalling pathways, and thus have physiological and pathophysiological effects. Carbon…”
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Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia by Phelan, David E, Reddan, Ben, Shigemura, Masahiko, Sznajder, Jacob I, Crean, Daniel, Cummins, Eoin P

“…Hypercapnia occurs when the partial pressure of carbon dioxide (CO ) in the blood exceeds 45 mmHg. Hypercapnia is associated with several lung pathologies and…”
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High CO2 Levels Cause Skeletal Muscle Atrophy via AMP-activated Kinase (AMPK), FoxO3a Protein, and Muscle-specific Ring Finger Protein 1 (MuRF1) by Jaitovich, Ariel, Angulo, Martín, Lecuona, Emilia, Dada, Laura A., Welch, Lynn C., Cheng, Yuan, Gusarova, Galina, Ceco, Ermelinda, Liu, Chang, Shigemura, Masahiko, Barreiro, Esther, Patterson, Cam, Nader, Gustavo A., Sznajder, Jacob I.

“…Patients with chronic obstructive pulmonary disease, acute lung injury, and critical care illness may develop hypercapnia. Many of these patients often have…”
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Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling by Shigemura, Masahiko, Lecuona, Emilia, Angulo, Martín, Homma, Tetsuya, Rodríguez, Diego A, Gonzalez-Gonzalez, Francisco J, Welch, Lynn C, Amarelle, Luciano, Kim, Seok-Jo, Kaminski, Naftali, Budinger, G R Scott, Solway, Julian, Sznajder, Jacob I

“…The elevation of carbon dioxide (CO ) in tissues and the bloodstream (hypercapnia) occurs in patients with severe lung diseases, including chronic obstructive…”
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Hypercapnia Regulates Gene Expression and Tissue Function by Shigemura, Masahiko, Welch, Lynn C, Sznajder, Jacob I

“…Carbon dioxide (CO ) is produced in eukaryotic cells primarily during aerobic respiration, resulting in higher CO levels in mammalian tissues than those in the…”
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Laboratory and clinical features of abnormal macroenzymes found in human sera by Moriyama, Takanori, Tamura, Shogo, Nakano, Keiichi, Otsuka, Kohei, Shigemura, Masahiko, Honma, Naoyuki

“…We report the analysis of unusual macroenzymes, performed in our laboratory, and review the relevant literature. In particular, we focused on macro AST,…”
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Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response by Phelan, David E, Shigemura, Masahiko, Aldhafiri, Sarah, Mota, Catarina, Hall, Thomas J, Sznajder, Jacob I, Murphy, Evelyn P, Crean, Daniel, Cummins, Eoin P

“…The nuclear receptor sub-family 4 group A (NR4A) family are early response genes that encode proteins that are activated in several tissues/cells in response…”
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Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation by Ceco, Ermelinda, Celli, Diego, Weinberg, Samuel, Shigemura, Masahiko, Welch, Lynn C., Volpe, Lena, Chandel, Navdeep S., Bharat, Ankit, Lecuona, Emilia, Sznajder, Jacob I.

“…Muscle dysfunction often occurs in patients with chronic obstructive pulmonary diseases (COPD) and affects ventilatory and non-ventilatory skeletal muscles. We…”
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Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans by Shigemura, Masahiko, Lecuona, Emilia, Angulo, Martín, Dada, Laura A., Edwards, Melanie B., Welch, Lynn C., Casalino-Matsuda, S. Marina, Sporn, Peter H. S., Vadász, István, Helenius, Iiro Taneli, Nader, Gustavo A., Gruenbaum, Yosef, Sharabi, Kfir, Cummins, Eoin, Taylor, Cormac, Bharat, Ankit, Gottardi, Cara J., Beitel, Greg J., Kaminski, Naftali, Budinger, G. R. Scott, Berdnikovs, Sergejs, Sznajder, Jacob I.

“…Carbon dioxide (CO 2 ) is sensed by cells and can trigger signals to modify gene expression in different tissues leading to changes in organismal functions…”
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TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells by Miyajima, Naoto, Maruyama, Satoru, Bohgaki, Miyuki, Kano, Satoshi, Shigemura, Masahiko, Shinohara, Nobuo, Nonomura, Katsuya, Hatakeyama, Shigetsugu

“…The androgen receptor (AR) is a transcription factor belonging to the family of nuclear receptors that mediate the action of androgen. AR plays an important…”
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Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells by Dada, Laura A, Welch, Lynn C, Magnani, Natalia D, Ren, Ziyou, Han, Hyebin, Brazee, Patricia L, Celli, Diego, Flozak, Annette S, Weng, Anthea, Herrerias, Mariana Maciel, Kryvenko, Vitalii, Vadász, István, Runyan, Constance E, Abdala-Valencia, Hiam, Shigemura, Masahiko, Casalino-Matsuda, S Marina, Misharin, Alexander V, Budinger, G R Scott, Gottardi, Cara J, Sznajder, Jacob I

“…Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital…”
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Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis by Shigemura, Masahiko, Nasuhara, Yasuyuki, Konno, Satoshi, Shimizu, Chikara, Matsuno, Kazuhiko, Yamguchi, Etsuro, Nishimura, Masaharu

“…Serum Krebs von den Lungen-6 (KL-6), which is classified as human mucin-1 (MUC1), is used as a marker of sarcoidosis and other interstitial lung diseases…”
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Development of a highly sensitive three-dimensional gel electrophoresis method for characterization of monoclonal protein heterogeneity by Nakano, Keiichi, Tamura, Shogo, Otuka, Kohei, Niizeki, Noriyasu, Shigemura, Masahiko, Shimizu, Chikara, Matsuno, Kazuhiko, Kobayashi, Seiichi, Moriyama, Takanori

“…Three-dimensional gel electrophoresis (3-DE), which combines agarose gel electrophoresis and isoelectric focusing/SDS–PAGE, was developed to characterize…”
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Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis by Shigemura, Masahiko, Nasuhara, Yasuyuki, Konno, Satoshi, Hattori, Takeshi, Shimizu, Chikara, Matsuno, Kazuhiko, Nishimura, Masaharu

“…There has been only one report showing high levels of transferrin (Tf) in bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis. This study was…”
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The role of atopy in the clinical course of pulmonary sarcoidosis in the Japanese population by Hattori, Takeshi, Konno, Satoshi, Takahashi, Ayumu, Isada, Akira, Shigemura, Masahiko, Matsuno, Kazuhiko, Shimizu, Chikara, Hizawa, Nobuyuki, Yamaguchi, Etsuro, Nishimura, Masaharu

“…Sarcoidosis is a multisystem disorder characterized by a T-helper 1 (Th1)-mediated immune response. Conversely, atopy is characterized by the presence of a…”
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Elevated CO2 modulates airway contractility by Shigemura, Masahiko, Sznajder, Jacob I

“…Carbon dioxide (CO 2 ), a primary product of oxidative metabolism, can be sensed by eukaryotic cells eliciting unique responses via specific signalling…”
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Establishment and Characterization of Amylase-producing Lung Adenocarcinoma Cell Line, IMEC-2 by YOKOUCHI, Hiroshi, YAMAZAKI, Koichi, TSUTSUMI, Yutaka, NISHIMURA, Masaharu, ASAHINA, Hajime, SHIGEMURA, Masahiko, MORIYAMA, Takanori, TAKAOKA, Kazuo, MORIYA, Jun, ITOH, Tomoo, KINOSHITA, Ichiro, DOSAKA-AKITA, Hirotoshi

“…Background: Few studies have successfully established an amylase-producing lung cancer cell line or have examined its cytological, biochemical and biological…”
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Elevated CO 2 modulates airway contractility by Shigemura, Masahiko, Sznajder, Jacob I

“…Carbon dioxide (CO ), a primary product of oxidative metabolism, can be sensed by eukaryotic cells eliciting unique responses via specific signalling pathways…”
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Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery by Amarelle, Luciano, Katzen, Jeremy, Shigemura, Masahiko, Welch, Lynn C, Cajigas, Héctor, Peteranderl, Christin, Celli, Diego, Herold, Susanne, Lecuona, Emilia, Sznajder, Jacob I

“…Cardiac glycosides (CGs) are used primarily for cardiac failure and have been reported to have other effects, including inhibition of viral replication. Here…”
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High CO2 Levels Impair Lung Wound Healing by Bharat, Ankit, Angulo, Martín, Sun, Haiying, Akbarpour, Mahzad, Alberro, Andrés, Cheng, Yuan, Shigemura, Masahiko, Berdnikovs, Sergejs, Welch, Lynn C, Kanter, Jacob A, Budinger, G R Scott, Lecuona, Emilia, Sznajder, Jacob I

“…Bharat et al discuss their study on the impact of high carbon dioxide levels on lung wound healing. Delayed lung repair leads to alveolopleural fistulae, which…”
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