Search Results - "Shigehiro OSADA"

Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity by Katoh, Daiki, Nishizuka, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…Metastasis is the main cause of death in patients with cancer, and understanding the mechanisms of metastatic processes is essential for the development of…”
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Ratiometric assay of CARM1 activity using a FRET-based fluorescent probe by Ohta, Yuhei, Wakita, Hiroo, Kawaguchi, Mitsuyasu, Ieda, Naoya, Osada, Shigehiro, Nakagawa, Hidehiko

“…[Display omitted] One of the regulatory mechanisms of epigenetic gene expression is the post-translational methylation of arginine residues, which is catalyzed…”
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Fad24, a Positive Regulator of Adipogenesis, Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27(Kip1) Expression at the Protein Level by Ochiai, Natsuki, Nishizuka, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…Factor for adipocyte differentiation 24 (fad24) is a positive regulator of adipogenesis. We previously found that human fad24 is abundantly expressed in…”
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FAD104, a Regulator of Adipogenesis and Osteogenesis, Interacts with the C-Terminal Region of STAT3 and Represses Malignant Transformation of Melanoma Cells by Katoh, Daiki, Nishizuka, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…Anchorage-independent growth is one of the defining characteristics of cancer cells. Many oncogenes and tumor suppressor genes are involved in regulating this…”
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Wnt4 and Wnt5a promote adipocyte differentiation by Nishizuka, Makoto, Koyanagi, Akiko, Osada, Shigehiro, Imagawa, Masayoshi

“…The roles of the non-canonical Wnt pathway during adipogenesis are not well known, though Wnt10b is known to function as a negative regulator for adipogenesis…”
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Fad24, a Positive Regulator of Adipogenesis, Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27Kip1 Expression at the Protein Level by Ochiai, Natsuki, Nishizuka, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…Factor for adipocyte differentiation 24 (fad24) is a positive regulator of adipogenesis. We previously found that human fad24 is abundantly expressed in…”
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Cannabidiol metabolism revisited: tentative identification of novel decarbonylated metabolites of cannabidiol formed by human liver microsomes and recombinant cytochrome P450 3A4 by Watanabe, Kazuhito, Usami, Noriyuki, Osada, Shigehiro, Narimatsu, Shizuo, Yamamoto, Ikuo, Yoshimura, Hidetoshi

“…Purpose The purpose of the present study was to identify the structures of cannabidiol (CBD) metabolites during CO formation by human liver microsomes and…”
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FAD24 Acts in Concert with Histone Acetyltransferase HBO1 to Promote Adipogenesis by Controlling DNA Replication by Johmura, Yoshikazu, Osada, Shigehiro, Nishizuka, Makoto, Imagawa, Masayoshi

“…Preadipocytes differentiate into adipocytes through approximately two rounds of mitosis, referred to as mitotic clonal expansion (MCE), but the events early in…”
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FAD104, a Regulatory Factor of Adipogenesis, Acts as a Novel Regulator of Calvarial Bone Formation by Kishimoto, Keishi, Nishizuka, Makoto, Katoh, Daiki, Kato, Ayumi, Osada, Shigehiro, Imagawa, Masayoshi

“…Osteogenesis is a complex process that is orchestrated by several growth factors, extracellular cues, signaling molecules, and transcriptional factors…”
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KCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation by Nishizuka, Makoto, Hayashi, Takahiro, Asano, Mami, Osada, Shigehiro, Imagawa, Masayoshi

“…KCNK10, a member of tandem pore domain potassium channel family, gives rise to leak K+ currents. It plays important roles in stabilizing the negative resting…”
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Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage by Ochiai, Natsuki, Nishizuka, Makoto, Miyamoto, Tomomi, Miyoshi, Ichiro, Ikawa, Masahito, Osada, Shigehiro, Imagawa, Masayoshi

“…•We generated fad24-deficient mice by gene targeting.•fad24-null mutant embryos were not recovered after E9.5.•The development of fad24-null embryos ceases…”
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Factor for Adipocyte Differentiation 158 Gene Disruption Prevents the Body Weight Gain and Insulin Resistance Induced by a High-Fat Diet by Hayashi, Takahiro, Nozaki, Yuriko, Nishizuka, Makoto, Ikawa, Masahito, Osada, Shigehiro, Imagawa, Masayoshi

“…To clarify the molecular mechanism of adipocyte differentiation, we previously isolated a novel gene, factor for adipocyte differentiation (fad) 158, whose…”
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novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion by Hishida, Tomoaki, Eguchi, Tsuyoshi, Osada, Shigehiro, Nishizuka, Makoto, Imagawa, Masayoshi

“…Adipogenesis is accomplished via a complex series of steps, and the events at the earliest stage remain to be elucidated. To clarify the molecular mechanisms…”
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FAD24, a Regulator of Adipogenesis, is Required for the Regulation of DNA Replication in Cell Proliferation by Johmura, Yoshikazu, Osada, Shigehiro, Nishizuka, Makoto, Imagawa, Masayoshi

“…A novel gene, factor for adipocyte differentiation 24 (fad24), promotes adipogenesis by controlling DNA replication early on during a stage referred to as…”
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Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression by Ohno, Masae, Kunimoto, Masaaki, Nishizuka, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…The farnesoid X receptor (FXR; NR1H4) is a member of the nuclear receptor superfamily and regulates the expression of genes involved in enterohepatic…”
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Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element by Tachibana, Keisuke, Takeuchi, Kentaro, Inada, Hirohiko, Sugimoto, Ken, Ishimoto, Kenji, Yamashita, Masanori, Maegawa, Takashi, Yamasaki, Daisuke, Osada, Shigehiro, Tanaka, Toshiya, Rakugi, Hiromi, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Doi, Takefumi

“…Human mannose-binding lectin (MBL) is encoded by the MBL2 gene and is a key player in innate immunity. However, the mechanism of the transcriptional regulation…”
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TC10-Like/TC10βLong Regulates Adipogenesis by Controlling Mitotic Clonal Expansion by Kawaji, Atsuko, Nishizuka, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…To elucidate molecular mechanisms of adipocyte differentiation, we previously isolated TC10-like/TC10βLong (TCL/TC10βL), regulators of G protein signaling 2…”
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Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration by Nishizuka, Makoto, Kishimoto, Keishi, Kato, Ayumi, Ikawa, Masahito, Okabe, Masaru, Sato, Ryuichiro, Niida, Hiroyuki, Nakanishi, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…The molecular mechanisms at the beginning of adipogenesis remain unknown. Previously, we identified a novel gene, fad104 (factor for adipocyte differentiation…”
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Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation by Kishimoto, Keishi, Nishizuka, Makoto, Ueda, Takashi, Kajita, Kenji, Ugawa, Shinya, Shimada, Shoichi, Osada, Shigehiro, Imagawa, Masayoshi

“…Factor for adipocyte differentiation 104 (fad104) is a regulator of adipogenesis and osteogenesis. Our previous study showed that fad104-deficient mice died…”
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Interactions of Thyroid Hormone Receptor with Ku Proteins and Interleukin Enhancer Binding Factor 3 Modulate the Promoter Activity of Thyroid-Stimulating Hormone Alpha by Ohno, Masae, Fujita, Mayu, Nishizuka, Makoto, Osada, Shigehiro, Imagawa, Masayoshi

“…We previously identified Ku proteins and interleukin enhancer binding factor 3 (ILF3) as cofactors for the nuclear receptor farnesoid X receptor and liver…”
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