Search Results - "Shigehara, E"

Formation of glycine conjugate and (-)-(R)-enantiomer from (+)-(S)-2-phenylpropionic acid suggesting the formation of the CoA thioester intermediate of (+)-(S)-enantiomer in dogs by Tanaka, Y, Shimomura, Y, Hirota, T, Nozaki, A, Ebata, M, Takasaki, W, Shigehara, E, Hayashi, R, Caldwell, J

“…It has been proposed that the chiral inversion of the 2-arylpropionic acids is due to the stereospecific formation of the (-)-R-profenyl-CoA thioesters which…”
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Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys by KOMAI, T, KAWAI, K, TOKUI, T, TOKUI, Y, KUROIWA, C, SHIGEHARA, E, TANAKA, M

“…Pravastatin sodium (pravastatin) is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, and was found to be highly effective in…”
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Whole-body autoradiography of bumetanide-14C in dogs by round saw method.--A combined method of autoradiography and tissue radioassay by Shindo, H, Nakajima, E, Shigehara, E

“…The distribution of a new potent diuretic, Bumetanide, in dogs was studied by means of a combined method of whole-body autoradiography and tissue radioassay,…”
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WHOLE-BODY AUTORADIOGRAPHIC STUDIES ON TISSUE DISTRIBUTION OF 3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL) METHYL]-1-(2-CHLOROETHYL)-1-NITROSOUREA HYDROCHLORIDE IN TUMOR-BEARING MICE AND RATS by SHIGEHARA, Eiji, TANAKA, Minoru

“…Tissue distribution of 3-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU), a new water-soluble antitumor agent,…”
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Stereoselective Pharmacokinetics of RS-8359, A Selective and Reversible Inhibitor of A-Type Monoamine Oxidase, in Rats, Mice, Dogs, and Monkeys by TAKASAKI, Wataru, YAMAMURA, Mayumi, SHIGEHARA, Eiji, SUZUKI, Yuko, TONOHIRO, Toshiyuki, HARA, Takao, TANAKA, Yorihisa

“…RS-8359, (±)-4-(4-cyanoanilino)-5, 6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine, inhibits, selectively and reversely, A-type monoamine oxidase (MAO-A). In…”
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Carrier-mediated uptake of pravastatin by rat hepatocytes in primary culture by Komai, T, Shigehara, E, Tokui, T, Koga, T, Ishigami, M, Kuroiwa, C, Horiuchi, S

“…The transport mechanism of pravastatin, a new cholesterol-lowering drug, was compared in vitro with rat hepatocyte primary culture and mouse skin fibroblasts…”
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Application of FHM-based design method to scalable 2-D DCT processor by Shigehara, E., Takeuchi, Y., Imai, M., Kimura, T.

“…This paper studies digital signal processor design using Flexible Hardware Model (FHM). The proposed method is based on design reuse and a quantitative…”
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Mercury distribution in mouse brain after i.v. administration of bis(methylmercuric) selenide by Naganuma, A, Nakajima, E, Shigehara, E, Tanaka, M, Imura, N

“…The distribution of mercury in the brain of mice after i.v. administration of methylmercury, methylmercury with selenite, or bis(methylmercuric) selenide (BMS)…”
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Autoradiographic Studies on the Distribution of Quaternary Ammonium Compounds. IV. Adsorption of Bisonium Ions to Rat Tissues as revealed by in Vitro Whole-body Adsorption Autoradiography by SHINDO, HIDEYO, NAKAJIMA, EIICHI, SHIGEHARA, EIJI

“…A technique which was designated as"whole-body adsorption autoradiography"was applied to find binding characteristics of bis- and mono-quaternary ammonium ions…”
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The Mechanism of Comparable Serum Cholesterol Lowering Effects of Pravastatin Sodium, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Inhibitor, between Once- and Twice-Daily Treatment Regimens in Beagle Dogs and Rabbits by Fujioka, Tomoyuki, Nara, Futoshi, Shimada, Yoko, Fukushige, Junichiro, Shimotsu, Hidenori, Shigehara, Eiji, Fukami, Masaharu, Tsujita, Yoshio

“…In dogs, no significant difference in the reduction of serum cholesterol was observed among three dosing regimens of pravastatin: once in the morning (3…”
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Autoradiographic Studies on the Distribution of Quaternary Ammonium Compounds. III. Distribution, Excretion and Metabolism of 14C-Labeled Pancuronium Bromide in Rats by SHINDO, HIDEYO, NAKAJIMA, EIICHI, MIYAKOSHI, NOBUHIRO, SHIGEHARA, EIJI

“…The distribution, excretion and metabolism of 14C-labeled pancuronium bromide following intraperitoneal administration to rats were investigated by means of…”
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The relation between structure and distribution of quaternary ammonium ions in mice and rats. Simple tetraalkylammonium and a series of m-substituted trimethylphenylammonium ions by Tsubaki, H, Nakajima, E, Shigehara, E, Komai, T, Shindo, H

“…In order to determine the relationship between structure and distribution in mono-quaternary ammonium ions, the distribution of a series of 14C-labeled…”
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