Tramadol Has No Effect on Cortical Renal Blood Flow—Despite Increased Serum Catecholamine Levels—in Anesthetized Rats: Implications for Analgesia in Renal Insufficiency

Tramadol Has No Effect on Cortical Renal Blood Flow—Despite Increased Serum Catecholamine Levels—in Anesthetized Rats: Implications for Analgesia in Renal Insufficiency

Tramadol is an analgesic that inhibits norepinephrine (NE) reuptake. Although NE released from renal sympathetic nerves causes renal hypoperfusion, the effects of tramadol on renal hemodynamics have not been well characterized. We investigated the effects of tramadol on renal blood flow (RBF), mean...

Full description

Saved in:
Bibliographic Details
Published in:Anesthesia and analgesia Vol. 94; no. 3; pp. 619 - 625
Main Authors: Nagaoka, Etsuko, Minami, Kouichiro, Shiga, Yohsuke, Uezono, Yasuhito, Shiraishi, Munehiro, Aoyama, Kazuyoshi, Shigematsu, Akio
Format: Journal Article
Language:English
Published: Hagerstown, MD International Anesthesia Research Society 01-03-2002
Lippincott
Subjects:
Analgesia
Analgesics
Analgesics, Opioid - pharmacology
Anesthesia
Animals
Biological and medical sciences
Blood Pressure - drug effects
Heart Rate - drug effects
Male
Medical sciences
Neuropharmacology
Norepinephrine - blood
Pharmacology. Drug treatments
Rats
Rats, Wistar
Renal Circulation - drug effects
Renal Insufficiency - physiopathology
Tramadol - pharmacology
Kidney disease
Urinary system disease
Rat
Rodentia
Catecholamine
Kidney
Blood flow
Vertebrata
Mammalia
Analgesic
Animal
Tramadol
Renal failure
Norepinephrine
Hemodynamics
Renal cortex
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tramadol is an analgesic that inhibits norepinephrine (NE) reuptake. Although NE released from renal sympathetic nerves causes renal hypoperfusion, the effects of tramadol on renal hemodynamics have not been well characterized. We investigated the effects of tramadol on renal blood flow (RBF), mean arterial blood pressure (MAP), and heart rate (HR) by using a laser Doppler flowmeter, both in normal anesthetized rats and in rats with experimentally-induced nephritis secondary to anti-Thy 1.1 antibody administration. We also studied the effects of tramadol on serum NE levels. Tramadol increased MAP and decreased HR without changing RBF in normal rats at clinical doses. Serum NE levels increased up to 176% of control after a 2 mg/kg bolus injection of tramadol. Continuously infused, increasing doses of tramadol (0.5–4 mg · kg−1 · h−1) did not affect MAP, HR, or RBF. Tramadol also increased MAP and decreased HR without changing RBF in rats with experimentally induced renal insufficiency. These findings suggest that a bolus injection of tramadol does not alter RBF, although it causes a decrease in HR and an increase in MAP and serum NE in both normal rats and in rats with renal insufficiency. These results suggest that tramadol may have little effect on RBF during the postoperative period.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-2999
1526-7598
DOI:10.1097/00000539-200203000-00026