Search Results - "Shiels, Paul"

'Debugging' heart failure by Shiels, Paul G

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Klotho, Aging, and the Failing Kidney by Buchanan, Sarah, Combet, Emilie, Stenvinkel, Peter, Shiels, Paul G

“…Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of…”
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Food as medicine: targeting the uraemic phenotype in chronic kidney disease by Mafra, Denise, Borges, Natalia A., Lindholm, Bengt, Shiels, Paul G., Evenepoel, Pieter, Stenvinkel, Peter

“…The observation that unhealthy diets (those that are low in whole grains, fruits and vegetables, and high in sugar, salt, saturated fat and ultra-processed…”
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The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism by Sebastián, Carlos, Zwaans, Bernadette M.M., Silberman, Dafne M., Gymrek, Melissa, Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica, Guimaraes, Alexander R., Toiber, Debra, Cosentino, Claudia, Greenson, Joel K., MacDonald, Alasdair I., McGlynn, Liane, Maxwell, Fraser, Edwards, Joanne, Giacosa, Sofia, Guccione, Ernesto, Weissleder, Ralph, Bernstein, Bradley E., Regev, Aviv, Shiels, Paul G., Lombard, David B., Mostoslavsky, Raul

“…Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating…”
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More miles on the clock: Neighbourhood stressors are associated with telomere length in a longitudinal study by Ellaway, Anne, Dundas, Ruth, Robertson, Tony, Shiels, Paul G

“…There is a substantial gap in health and longevity between more affluent and more deprived areas, and more knowledge of the determinants of this health divide…”
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Ageing – Oxidative stress, PTMs and disease by Ebert, Thomas, Tran, Ngoc, Schurgers, Leon, Stenvinkel, Peter, Shiels, Paul G.

“…Post-translational modifications (PTMs) have been proposed as a link between the oxidative stress-inflammation-ageing trinity, thereby affecting several…”
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The Impact of Enriched Resistant Starch Type‐2 Cookies on the Gut Microbiome in Hemodialysis Patients: A Randomized Controlled Trial by Kemp, Julie Ann, Regis de Paiva, Bruna, Fragoso dos Santos, Henrique, Emiliano de Jesus, Hugo, Craven, Hannah, Z. Ijaz, Umer, Alvarenga Borges, Natalia, G. Shiels, Paul, Mafra, Denise

“…Introduction Resistant starch type‐2 (RS2) can mitigate inflammation and oxidative stress in hemodialysis (HD) patients. However, there is still a lack of…”
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Reproducibility of telomere length assessment: an international collaborative study by Martin-Ruiz, Carmen M, Baird, Duncan, Roger, Laureline, Boukamp, Petra, Krunic, Damir, Cawthon, Richard, Dokter, Martin M, van der Harst, Pim, Bekaert, Sofie, de Meyer, Tim, Roos, Goran, Svenson, Ulrika, Codd, Veryan, Samani, Nilesh J, McGlynn, Liane, Shiels, Paul G, Pooley, Karen A, Dunning, Alison M, Cooper, Rachel, Wong, Andrew, Kingston, Andrew, von Zglinicki, Thomas

“…Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and…”
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Telomere Homeostasis: Interplay with Magnesium by Maguire, Donogh, Neytchev, Ognian, Talwar, Dinesh, McMillan, Donald, Shiels, Paul G

“…Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related…”
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Inflammation and Premature Ageing in Chronic Kidney Disease by Ebert, Thomas, Pawelzik, Sven-Christian, Witasp, Anna, Arefin, Samsul, Hobson, Sam, Kublickiene, Karolina, Shiels, Paul G, Bäck, Magnus, Stenvinkel, Peter

“…Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life,…”
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Inflammation and premature aging in advanced chronic kidney disease by Kooman, Jeroen P, Dekker, Marijke J, Usvyat, Len A, Kotanko, Peter, van der Sande, Frank M, Schalkwijk, Casper G, Shiels, Paul G, Stenvinkel, Peter

“…Systemic inflammation in end-stage renal disease is an established risk factor for mortality and a catalyst for other complications, which are related to a…”
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Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage by Dai, Lu, Schurgers, Leon J, Shiels, Paul G, Stenvinkel, Peter

“…Abstract Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by cardiovascular disease, persistent uraemic inflammation,…”
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Long-lived animals with negligible senescence: clues for ageing research by Stenvinkel, Peter, Shiels, Paul G

“…Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention…”
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Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature by Lang, Jason, McKie, Judith, Smith, Helen, McLaughlin, Angela, Gillberg, Christopher, Shiels, Paul G., Minnis, Helen

“…A systematic review following PRISMA guidelines was conducted to answer the question: What epigenetic, telomeric and associated biological changes are…”
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Allostatic load and ageing: linking the microbiome and nutrition with age-related health by Shiels, Paul G, Buchanan, Sarah, Selman, Colin, Stenvinkel, Peter

“…Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an…”
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Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment by Hobson, Sam, Arefin, Samsul, Kublickiene, Karolina, Shiels, Paul G, Stenvinkel, Peter

“…Together with bone-mineral disorders, premature vascular ageing is a common feature of the uremic phenotype. A detailed understanding of mechanisms involved…”
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The oxygen cascade in patients treated with hemodialysis and native high-altitude dwellers: lessons from extreme physiology to benefit patients with end-stage renal disease by Kooman, Jeroen P, Stenvinkel, Peter, Shiels, Paul G, Feelisch, Martin, Canaud, Bernard, Kotanko, Peter

“…Patients treated with hemodialysis (HD) repeatedly undergo intradialytic low arterial oxygen saturation and low central venous oxygen saturation, reflecting an…”
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Metabolic syndrome in combination with chronic kidney disease—It´s a gut feeling by Stenvinkel, Peter, Shiels, Paul G.

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Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants by Zhou, Ziyi, Lo, Camilla K. M., Chan, Ko Ling, Chung, Rachel S. Y., Pell, Jill P., Minnis, Helen, Shiels, Paul G., Ip, Patrick, Ho, Frederick K.

“…There is evidence that child maltreatment is associated with shorter telomere length in early life. This study aims to examine if child maltreatment is…”
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SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients by McGlynn, Liane M, McCluney, Simon, Jamieson, Nigel B, Thomson, Jackie, MacDonald, Alasdair I, Oien, Karin, Dickson, Euan J, Carter, C Ross, McKay, Colin J, Shiels, Paul G

“…The sirtuin gene family has been linked with tumourigenesis, in both a tumour promoter and suppressor capacity. Information regarding the function of sirtuins…”
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