Search Results - "Shiels, H."

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter by Marris, C. R., Kompella, S. N., Miller, M. R., Incardona, J. P., Brette, F., Hancox, J. C., Sørhus, E., Shiels, H. A.

“…Air pollution is associated with detrimental effects on human health, including decreased cardiovascular function. However, the causative mechanisms behind…”
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The key characteristics of cardiotoxicity for the pervasive pollutant phenanthrene by England, E., Morris, J.W., Bussy, C., Hancox, J.C., Shiels, H.A.

“…The key characteristic (KCs) framework has been used previously to assess the carcinogenicity and cardiotoxicity of various chemical and pharmacological…”
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Cardiac function in an endothermic fish: cellular mechanisms for overcoming acute thermal challenges during diving by Shiels, H. A., Galli, G. L. J., Block, B. A.

“…Understanding the physiology of vertebrate thermal tolerance is critical for predicting how animals respond to climate change. Pacific bluefin tuna experience…”
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Warm fish with cold hearts: thermal plasticity of excitation–contraction coupling in bluefin tuna by Shiels, H. A., Di Maio, A., Thompson, S., Block, B. A.

“…Bluefin tuna have a unique physiology. Elevated metabolic rates coupled with heat exchangers enable bluefin tunas to conserve heat in their locomotory muscle,…”
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Kinematics and energetics of swimming performance during acute warming in brown trout Salmo trutta by Lea, J. M. D., Keen, A. N., Nudds, R. L., Shiels, H. A.

“…This study examined how acute warming of water temperature affects the mechanical efficiency of swimming and aerobic capabilities of the brown trout Salmo…”
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The influence of deprivation in the outcomes of psoriatic arthritis within the UK-utilizing Outcomes of Treatment in Psoriatic Arthritis Study Syndicate (OUTPASS) data by Lyon, Max, Zhao, Sizheng Steven, Jani, Meghna, Chinoy, Hector, Barton, Anne, Bluett, James

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The effect of stimulation frequency on the transmural ventricular monophasic action potential in yellowfin tuna Thunnus albacares by Patrick, S. M., White, E., Brill, R. W., Shiels, H. A.

“…Monophasic action potentials (MAPs) were recorded from the spongy and compact layers of the yellowfin tuna Thunnus albacares ventricle as stimulation frequency…”
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Hypercapnic Acidosis Reduces Contractile Function in the Ventricle of the Armored Catfish,Pterygoplichthys pardalis by Shiels, H. A., Santiago, D. A., Galli, G. L. J.

“…The armored catfish,Pterygoplichthys pardalis(formerlyLiposarcus pardalis), is a freshwater, facultative air‐breathing teleost that experiences seasonal…”
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The effect of temperature and adrenaline on the relative importance of the sarcoplasmic reticulum in contributing Ca2+ to force development in isolated ventricular trabeculae from rainbow trout by Shiels, H, Farrell, A

“…The sarcoplasmic reticulum (SR) is central to intracellular Ca2+ regulation during excitation­contraction (E-C) coupling in mammalian cardiac tissue. The…”
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The impact of abdominal aortic aneurysm surgery on intensive care unit resources in an Irish tertiary centre by Shiels, H., Desmond, A. N., Parimkayala, R., Cahill, J.

“…Background The potential impact of surgical service reconfiguration on intensive care unit (ICU) resources needs to be assessed. Aims To determine the…”
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Acute Temperature Change Modulates the Response of ICa to Adrenergic Stimulation in Fish Cardiomyocytes by Shiels, H. A., Vornanen, M., Farrell, A. P.

“…The purpose of this study was to investigate how the endogenous catecholamine adrenaline protects sarcolemmal Ca2+ flux through the L-type Ca2+ channel (ICa)…”
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A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors by Duckett, C. S., Nava, V. E., Gedrich, R. W., Clem, R. J., Van Dongen, J. L., Gilfillan, M. C., Shiels, H., Hardwick, J. M., Thompson, C. B.

“…The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells…”
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The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues by Lindsten, Tullia, Ross, Andrea J, King, Ayala, Zong, Wei-Xing, Rathmell, Jeffrey C, Shiels, Helena A, Ulrich, Eugen, Waymire, Katrina G, Mahar, Patryce, Frauwirth, Kenneth, Chen, Yifeng, Wei, Michael, Eng, Vicki M, Adelman, David M, Simon, M.Celeste, Ma, Averil, Golden, Jeffrey A, Evan, Gerard, Korsmeyer, Stanley J, MacGregor, Grant R, Thompson, Craig B

“…Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic…”
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Temperature-dependence of L-type Ca(2+) channel current in atrial myocytes from rainbow trout by Shiels, H A, Vornanen, M, Farrell, A P

“…Rainbow trout, Oncorhynchus mykiss, inhabit eurythermal environments and must therefore be able to cope with changes in environmental temperature. As…”
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Electrophysiological properties of the L-type Ca(2+) current in cardiomyocytes from bluefin tuna and Pacific mackerel by Shiels, H A, Blank, J M, Farrell, A P, Block, B A

“…Tunas are capable of exceptionally high maximum metabolic rates; such capability requires rapid delivery of oxygen and metabolic substrate to the tissues. This…”
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Maximum cardiac performance of rainbow trout (Oncorhynchus mykiss) at temperatures approaching their upper lethal limit by Farrell, A, Gamperl, A, Hicks, J, Shiels, H, Jain, K

“…Numerous studies have examined the effect of temperature on in vivo and in situ cardiovascular function in trout. However, little information exists on cardiac…”
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J001 Comparison of length-dependent Ca2+ activation of cardiac myofilaments between the rat and the rainbow trout by Patrick, S, Shiels, H, Cazorla, O

“…Most fish regulate cardiac output via changes in stroke volume whereas most mammals regulate cardiac output via changes in heart rate. We hypothesized that…”
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1.5. Cardiac survival during temperature change from fish to mammals: a role for altered calcium homeostasis by Shiels, H., Crawford, F., Esward, M., Dibb, K., Loudon, A., Trafford, A.

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The effect of ryanodine on isometric tension development in isolated ventricular trabeculae from Pacific mackerel ( Scomber japonicus) by Shiels, H.A., Farrell, A.P.

“…An isometric muscle preparation was used to study the inhibitory effect of ryanodine on contractile function in isolated ventricular trabeculae of the Pacific…”
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Temperature-Dependence of L-Type Ca2+ Channel Current in Atrial Myocytes From Rainbow Trout by Shiels, H. A., Vornanen, M., Farrell, A. P.

“…ABSTRACT Rainbow trout, Oncorhynchus mykiss, inhabit eurythermal environments and must therefore be able to cope with changes in environmental temperature. As…”
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