Search Results - "Shields, Jordan E"

Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens by Lam, Phuong T, Padula, Stephanie L, Hoang, Thanh V, Poth, Justin E, Liu, Lin, Liang, Chun, LeFever, Adam S, Wallace, Lindsay M, Ashery-Padan, Ruth, Riggs, Penny K, Shields, Jordan E, Shaham, Ohad, Rowan, Sheldon, Brown, Nadean L, Glaser, Tom, Robinson, Michael L

“…Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line…”
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Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery by Brown, Harrison C, Wright, J Fraser, Zhou, Shangzhen, Lytle, Allison M, Shields, Jordan E, Spencer, H Trent, Doering, Christopher B

“…Clinical data support the feasibility and safety of adeno-associated viral (AAV) vectors in gene therapy applications. Despite several clinical trials of…”
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F5‐Atlanta: A novel mutation in F5 associated with enhanced East Texas splicing and FV‐short production by Zimowski, Karen L., Petrillo, Teodolinda, Ho, Michelle D., Wechsler, Julie, Shields, Jordan E., Denning, Gabriela, Jhita, Navdeep, Rivera, Angel A., Escobar, Miguel A., Kempton, Christine L., Camire, Rodney M., Doering, Christopher B.

“…Background Elucidating the molecular pathogenesis underlying East Texas bleeding disorder (ET) led to the discovery of alternatively spliced F5 transcripts…”
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Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency by Tran, Reginald, Myers, David R., Denning, Gabriela, Shields, Jordan E., Lytle, Allison M., Alrowais, Hommood, Qiu, Yongzhi, Sakurai, Yumiko, Li, William C., Brand, Oliver, Le Doux, Joseph M., Spencer, H. Trent, Doering, Christopher B., Lam, Wilbur A.

“…Ex vivo gene therapy using lentiviral vectors (LVs) is a proven approach to treat and potentially cure many hematologic disorders and malignancies but remains…”
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Treatment of a solid tumor using engineered drug-resistant immunocompetent cells and cytotoxic chemotherapy by Dasgupta, Anindya, Shields, Jordan E, Spencer, H Trent

“…Multimodal therapy approaches, such as combining chemotherapy agents with cellular immunotherapy, suffers from potential drug-mediated toxicity to immune…”
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Administration of FVIII-Expressing Human Placental Cells to Juvenile Sheep Yields Multi-Organ Engraftment, Therapeutic Plasma FVIII Levels and Alter Immune Signaling Pathways to Evade FVIII Inhibitor Induction by Trevisan, Brady, Rodriguez, Martin, Dizon, Jacqueline, George, Sunil, Shields, Jordan E, Lankford, Shannon, Combs, Rebecca, Owen, John, Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D, Almeida-Porada, M. Graca

“…We have previously reported that normal juvenile sheep that received weekly intravenous (IV) infusions of human (n=3) or an expression/secretion-optimized,…”
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In Utero Transplantation of FVIII-Expressing Human Placental Cells Upregulates Gene Pathways Associated with Immune Tolerance, Altering the Response to Postnatal FVIII Infusion by Rodriguez, Martin, Trevisan, Brady, George, Sunil, Shields, Jordan E, Figueroa, Jorge, Meares, Diane, Owen, John, Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D, Almeida-Porada, M. Graca

“…We have previously reported that in utero transplantation (IUTx) of sheep fetuses (n=14) with human placental cells (PLC) transduced with a lentiviral vector…”
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Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation by Trevisan, Brady, Rodriguez, Martin, George, Sunil, Lankford, Shannon, Shields, Jordan E, Figueroa, Jorge, Meares, Diane, Owen, John, Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D, Almeida-Porada, M. Graca

“…Hemophilia A (HA) is characterized by a decrease in the functional clotting protein factor VIII (FVIII). Current hemophilia treatments consist of either…”
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Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events by Rodriguez, Martin, Trevisan, Brady, George, Sunil, Ramamurthy, Ritu M, Rabah, Andrew, Shields, Jordan E, Schwahn, Denise, Figueroa, Jorge, Meares, Diane, Owen, John, Gautreaux, Michael, Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D, Almeida-Porada, M. Graca

“…The treatment of hemophilia A (HA) patients by prenatal transplantation (PNT) is a feasible, yet underestimated and unexplored clinical approach. The…”
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Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a by Doering, Christopher B, Denning, Gabriela, Shields, Jordan E, Swaney, William, Reeves, Lilith, Malik, Punam, Spencer, H. Trent

“…Hemophilia A is a monogenic bleeding disorder currently treated by lifelong infusions of factor VIII (fVIII). The development of gene-based treatments for…”
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Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth by Almeida-Porada, M. Graca, George, Sunil, Morsi, Alshaima, El-Akabawy, Nadia, Figueroa, Jorge, Shields, Jordan E, Meares, Diane, Farland, Andrew M., Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D

“…Prenatal transplantation (PNTx) is a clinically viable procedure that has been performed in ~50 human patients for 14 different genetic disorders. When…”
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Factor V Atlanta: A Novel Mutation in the F5 Gene Reveals Potential New Cis-Acting Elements Involved in Regulating FV-Short and TFPI Levels by Zimowski, Karen L, Ho, Michelle D., Shields, Jordan E, Denning, Gabriela, Petrillo, Teodolinda, Jhita, Navdeep, Rivera, Angel A, Escobar, Miguel A, Kempton, Christine L, Doering, Christopher B, Camire, Rodney M

“…Coagulation factor V (FV) is procofactor essential to normal hemostasis. Recently, a point mutation in exon 13 of the F5 gene (FV-East Texas; FV-ET), which…”
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Improving Lentiviral Transduction Efficiency with Microfluidic Systems by Tran, Reginald, Myers, David R, Shields, Jordan E, Ahn, Byungwook, Qiu, Yongzhi, Hansen, Caroline, Sakurai, Yumiko, Moot, Robert, Spencer, H. Trent, Doering, Christopher B, Lam, Wilbur A

“…Background: Recent clinical trials have demonstrated the efficacy and safety of gene therapy utilizing HIV-derived lentiviral vectors (LVs) for blood…”
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Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery by Brown, Harrison C., Shields, Jordan E, Zhou, Shangzhen, Wright, J. Fraser, Spencer, H. Trent, Doering, Christopher B

“…Preclinical and, more recently, clinical data support the feasibility and safety of recombinant adeno-associated viral vectors (rAAV) in gene therapy…”
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