Search Results - "Shields, Donna"

Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22 by Espinal, Alexis, Epperly, Michael W, Mukherjee, Amitava, Fisher, Renee, Shields, Donna, Wang, Hong, Huq, M Saiful, Hamade, Diala Fatima, Vlad, Anda M, Coffman, Lan, Buckanovich, Ronald, Yu, Jian, Leibowitz, Brian J, van Pijkeren, Jan-Peter, Patel, Ravi B, Stolz, Donna, Watkins, Simon, Ejaz, Asim, Greenberger, Joel S

“…(1) Background: The systemic administration of therapeutic agents to the intestine including cytokines, such as Interleukin-22 (IL-22), is compromised by…”
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Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF) by Mukherjee, Amitava, Epperly, Michael W., Fisher, Renee, Hou, Wen, Shields, Donna, Saiful Huq, M., Pifer, Phillip M., Mulherkar, Ria, Wilhite, Tyler J., Wang, Hong, Wipf, Peter, Greenberger, Joel S.

“…Cellular senescence is involved in the development of pulmonary fibrosis as well as in lung tissue repair and regeneration. Therefore, a strategy of removal of…”
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Two Strategies for the Development of Mitochondrion-Targeted Small Molecule Radiation Damage Mitigators by Rwigema, Jean-Claude M., M.D, Beck, Barbara, Ph.D, Wang, Wei, Ph.D, Doemling, Alexander, Ph.D, Epperly, Michael W., Ph.D, Shields, Donna, B.S, Goff, Julie P., M.S, Franicola, Darcy, B.S, Dixon, Tracy, V.T, Frantz, Marie-Céline, Ph.D, Wipf, Peter, Ph.D, Tyurina, Yulia, Ph.D, Kagan, Valerian E., Ph.D, Wang, Hong, Ph.D, Greenberger, Joel S., M.D

“…Purpose To evaluate the effectiveness of mitigation of acute ionizing radiation damage by mitochondrion-targeted small molecules. Methods and Materials We…”
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Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal Cells In Vitro and Increases Reticulocyte Micronuclei after Total-Body Irradiation by Goff, Julie P., Shields, Donna S., Seki, Mineaki, Choi, Serah, Epperly, Michael W., Dixon, Tracy, Wang, Hong, Bakkenist, Christopher J., Dertinger, Stephen D., Torous, Dorothea K., Wittschieben, John, Wood, Richard D., Greenberger, Joel S.

“…Mammalian POLQ (pol θ) is a specialized DNA polymerase with an unknown function in vivo. Roles have been proposed in chromosome stability, as a backup enzyme…”
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Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis by Mukherjee, Amitava, Epperly, Michael W., Shields, Donna, Hou, Wen, Fisher, Renee, Hamade, Diala, Wang, Hong, Saiful Huq, M., Bao, Riyue, Tabib, Tracy, Monier, Daisy, Watkins, Simon, Calderon, Michael, Greenberger, Joel S.

“…The role of cellular senescence in radiation-induced pulmonary fibrosis (RIPF) and the underlying mechanisms are unknown. We isolated radiation-induced…”
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Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells by Goff, Julie P, Shields, Donna S, Wang, Hong, Skoda, Erin M, Sprachman, Melissa M, Wipf, Peter, Garapati, Venkata Krishna, Atkinson, Jeffrey, London, Barry, Lazo, John S, Kagan, Valerian, Epperly, Michael W, Greenberger, Joel S

“…We evaluated the use of colony formation (colony-forming unit-granulocyte macrophage [CFU-GM], burst-forming unit erythroid [BFU-E], and colony-forming…”
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The autophagy-inducing drug carbamazepine is a radiation protector and mitigator by Kim, Hyun, Bernard, Mark E., Flickinger, John, Epperly, Michael W., Wang, Hong, Dixon, Tracy M., Shields, Donna, Houghton, Frank, Zhang, Xichen, Greenberger, Joel S.

“…Abstract Purpose: To determine whether Carbamazepine (CBZ) is a radiation protector and/or mitigator. Materials and methods: Murine hematopoietic progenitor…”
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Developing a model of best practice for teams managing crisis in people with dementia: a consensus approach by Yates, Jennifer, Stanyon, Miriam, Challis, David, Coleston-Shields, Donna Maria, Dening, Tom, Hoe, Juanita, Jawahar, Kaanthan, Lloyd-Evans, Brynmor, Moniz-Cook, Esme, Poland, Fiona, Streater, Amy, Trigg, Emma, Orrell, Martin

“…Teams delivering crisis resolution services for people with dementia and their carers provide short-term interventions to prevent admission to acute care…”
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Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): a study protocol for a randomised controlled trial of a Resource Kit by Coleston-Shields, Donna Maria, Challis, David, Worden, Angela, Broome, Emma, Dening, Tom, Guo, Boliang, Hoe, Juanita, Lloyd-Evans, Brynmor, Moniz-Cook, Esme, Morris, Steve, Poland, Fiona, Prothero, David, Orrell, Martin

“…Improving care at home for people with dementia is a core policy goal in the dementia strategies of many European countries. A challenge to effective home…”
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Screening of Antimicrobial Agents for In Vitro Radiation Protection and Mitigation Capacity, Including those Used in Supportive Care Regimens for Bone Marrow Transplant Recipients by Epperly, Michael W, Franicola, Darcy, Shields, Donna, Rwigema, Jean-Claude, Stone, Brandon, Zhang, Xichen, McBride, William, Georges, George, Wipf, Peter, Greenberger, Joel S

“…Antibiotic and antifungal agents used in supportive care regimens for bone marrow transplantation recipients contribute to a significant dose-modifying effect…”
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An Analysis of Reunifications Between Adopted Adults and Their Birth Relatives by Shields, Donna E., Nicholl, Patricia

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The ultrasound estimation of amniotic fluid volume in diamniotic twin pregnancies and prediction of peripartum outcomes by Magann, Everett F., MD, Doherty, Dorota A., PhD, Ennen, Christopher S., MD, Chauhan, Suneet P., MD, Shields, Donna, RDMS, Gjesdal, Shane M., MD, Morrison, John C., MD

“…Objective To determine ultrasonic estimations of amniotic fluid in diamniotic twins across gestation using the single deepest pocket (SDP) technique and…”
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Reduced Irradiation Pulmonary Fibrosis and Stromal Cell Migration in Smad3-/- Marrow Chimeric Mice by Epperly, Michael W, Franicola, Darcy, Zhang, Xichen, Nie, Suhua, Wang, Hong, Bahnson, Alfred B, Shields, Donna S, Goff, Julie P, Shen, Hongmei, Greenberger, Joel S

“…Pulmonary irradiation fibrosis involves migration to the lungs of bone marrow origin myofibroblast progenitor cells (marrow stromal cells (MSCs)). Smad3-/-…”
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Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3 −/− mice by Epperly, Michael W., Cao, Shaonan, Goff, Julie, Shields, Donna, Zhou, Shuanhu, Glowacki, Julie, Greenberger, Joel S.

“…To determine the role of Smad3 in modulating hematopoiesis, continuous bone marrow cultures were established from Smad3 −/− mice, and the longevity of…”
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Conceptualizing Dementia Crisis and Preferences for Resolution: A Public Perspective by Yates, Jennifer A., Stanyon, Miriam R., Redley, Marcus, Coleston-Shields, Donna Maria

“…Background: Crisis intervention services for people with dementia in the United Kingdom are poorly defined with no standardized model of working. This may be…”
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Increased Radioresistance,$G_{2}/M$Checkpoint Inhibition, and Impaired Migration of Bone Marrow Stromal Cell Lines Derived from$Smad3^{-/-}$Mice by Epperly, Michael W., Goff, Julie P., Zhang, Xichen, Niu, Yunyun, Shields, Donna S., Wang, Hong, Shen, Hongmei, Darcy Franicola, Alfred B. Bahnson, Nie, Suhua, Emily E. Greenberger, Greenberger, Joel S.

“…Smad3 protein is a prominent member of the Tgfb receptor signaling pathway.$Smad3^{-/-}$mice display decreased radiation-induced skin fibrosis, suggesting a…”
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Dementia care model: Promoting personhood through co-production by Bosco, Alessandro, Schneider, Justine, Coleston-Shields, Donna Maria, Orrell, Martin

“…•Coping mechanisms are associated with positive outcomes in relation to sense of self, dignity and quality of care.•Barriers to dignity negatively impact on…”
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Bone Marrow from CD18-/- (MAC-1-/-) Homozygous Deletion Recombinant Negative Mice Demonstrates Increased Longevity in Long-term Bone Marrow Culture and Decreased Contribution to Irradiation Pulmonary Damage by Epperly, Michael W, Shields, Donna, Niu, Yunyun, Carlos, Timothy, Greenberger, Joel S

“…Background: Bone marrow macrophage surface expression of CD18 (MAC-1, LFA1) is involved in cellular binding to V-CAM-1 and V-CAM-2 adhesion molecules expressed…”
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Abstract PO-081: LR-IL-22 protects the intestine to facilitate whole abdomen irradiation in ovarian cancer by Hamade, Diala Fatima, Fisher, Renee, Hou, Wen, Shields, Donna, Epperly, Michael W., Greenberger, Joel S.

“…Abstract Ovarian cancer is the most lethal gynecological cancer worldwide with an estimated 152,000 deaths per year. Despite optimal management with radical…”
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Abstract PO-025: Radiation-induced and FACS-sorted senescent tdTOMp16+ cells upregulate profibrotic genes in C57BL/6 stromal target cells by Mukherjee, Amitava, Epperly, Michael, Shields, Donna, Hou, Wen, Fisher, Renee, Hamade, Diala, Greenberger, Joel S.

“…Abstract Acute Radiation Syndrome and the multiorgan failure from delayed effects of acute radiation exposure present challenging consequences of radiation…”
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