Search Results - "Shibue, Taku"

Total Syntheses of Tubulysins by Shibue, Taku, Hirai, Toshihiro, Okamoto, Iwao, Morita, Nobuyoshi, Masu, Hyuma, Azumaya, Isao, Tamura, Osamu

“…The total syntheses of tetrapeptides tubulysins D (1 b), U (1 c), and V (1 d), which are potent tubulin polymerization inhibitors, are described. The synthesis…”
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Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline by Shibue, Taku, Okamoto, Iwao, Morita, Nobuyoshi, Morita, Hiroshi, Hirasawa, Yusuke, Hosoya, Takahiro, Tamura, Osamu

“…The synthesis and biological evaluation of stereoisomers in tubulysin D are described. The stereoselective synthesis of all possible stereoisomers of C-11 and…”
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Stereoselective synthesis of tubuvaline methyl ester and tubuphenylalanine, components of tubulysins, tubulin polymerization inhibitors by Shibue, Taku, Hirai, Toshihiro, Okamoto, Iwao, Morita, Nobuyoshi, Masu, Hyuma, Azumaya, Isao, Tamura, Osamu

“…Synthetic studies of two components of tubulysins, tubulin polymerization inhibitors are described. The highly stereoselective synthesis of tubuvaline methyl…”
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Stereoselective Synthesis of cis-2-Fluorocyclopropanecarboxylic Acid by Shibue, Taku, Fukuda, Yasumichi

“…A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective…”
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Efficient synthesis of cyclopropylhydrazine salts by Shibue, Taku, Fukuda, Yasumichi

“…An efficient procedure for the synthesis of cyclopropylhydrazine in the form of its salts is reported. The copper salt-catalyzed addition of cyclopropylboronic…”
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Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9) by Singh, Sheo B., Tan, Christopher M., Kaelin, David, Meinke, Peter T., Miesel, Lynn, Olsen, David B., Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Ohata, Kohei, Takeuchi, Tomoko, Shibue, Taku, Takano, Hisashi, Nishimura, Akinori, Fukuda, Yasumichi

“…[Display omitted] Novel bacterial topoisomerase inhibitors (NBTIs) are the newest members of gyrase inhibitor broad-spectrum antibacterial agents, represented…”
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Synthesis and Structure−Activity Relationship Studies of Highly Potent Novel Oxazolidinone Antibacterials by Komine, Takashi, Kojima, Akihiko, Asahina, Yoshikazu, Saito, Tatsuhiro, Takano, Hisashi, Shibue, Taku, Fukuda, Yasumichi

“…Novel antibacterial biaryl oxazolidinones bearing an aza-, an oxa-, or a thiabicyclo[3.1.0]hex-6-yl ring system were synthesized, and their in vitro…”
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In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase by Tan, Christopher M, Gill, Charles J, Wu, Jin, Toussaint, Nathalie, Yin, Jingjun, Tsuchiya, Takayuki, Garlisi, Charles G, Kaelin, David, Meinke, Peter T, Miesel, Lynn, Olsen, David B, Lagrutta, Armando, Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Oohata, Kouhei, Takeuchi, Tomoko, Shibue, Taku, Takano, Hisashi, Nishimura, Akinori, Fukuda, Yasumichi, Singh, Sheo B

“…Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors (NBTIs) represent a new class of recently described antibacterial agents with broad-spectrum…”
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Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3) by Singh, Sheo B., Kaelin, David E., Wu, Jin, Miesel, Lynn, Tan, Christopher M., Gill, Charles, Black, Todd, Nargund, Ravi, Meinke, Peter T., Olsen, David B., Lagrutta, Armando, Wei, Changqing, Peng, Xuanjia, Wang, Xiu, Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Takeuchi, Tomoko, Shibue, Taku, Ohata, Kohei, Takano, Hisashi, Ban, Shizuka, Nishimura, Akinori, Fukuda, Yasumichi

“…[Display omitted] Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of broad-spectrum antibacterial agents targeting bacterial Gyrase A and ParC…”
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Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6) by Singh, Sheo B., Kaelin, David E., Wu, Jin, Miesel, Lynn, Tan, Christopher M., Meinke, Peter T., Olsen, David B., Lagrutta, Armando, Wei, Changqing, Liao, Yonggang, Peng, Xuanjia, Wang, Xiu, Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Yajima, Masanobu, Shibue, Taku, Shibata, Takeshi, Ohata, Kohei, Nishimura, Akinori, Fukuda, Yasumichi

“…[Display omitted] Oxabicyclooctane linked 1,5-naphthyridinyl-pyridoxazinones are novel broad-spectrum bacterial topoisomerase inhibitors (NBTIs) targeting…”
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Structures, Biological Activities, and Total Syntheses of 13-Hydroxy- and 13-Acetoxy-14-nordehydrocacalohastine, Novel Modified Furanoeremophilane-Type Sesquiterpenes from Trichilia cuneata by Doe, Matsumi, Shibue, Taku, Haraguchi, Hiroyuki, Morimoto, Yoshiki

“…13-Hydroxy-14-nordehydrocacalohastine (2) and 13-acetoxy-14-nordehydrocacalohastine (3), two novel modified furanoeremophilane-type sesquiterpenes isolated…”
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Synthesis of spiro[4.5]decane and bicyclo[4.3.0]nonane ring systems by self-cyclization of ( Z)- and ( E)-2-(trimethylsilylmethyl)pentadienal derivative by Kuroda, Chiaki, Honda, Shigenobu, Nagura, Yuki, Koshio, Hiroyuki, Shibue, Taku, Takeshita, Tokio

“…The two title carbon frameworks were synthesized utilizing a new type of iron-induced cyclization reaction of 2-(trimethylsilylmethyl)pentadienal…”
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