Search Results - "Shibata, Norio"

Development of Shelf-Stable Reagents for Fluoro-Functionalization Reactions by Shibata, Norio

“…It is highly probable that the first impression that organic chemists would have of fluorine, F, is that it is “dangerous”. Elemental fluorine, F2, is a gas…”
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Contribution of Organofluorine Compounds to Pharmaceuticals by Inoue, Munenori, Sumii, Yuji, Shibata, Norio

“…Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s, fluorine-containing pharmaceuticals, which are also…”
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Current Contributions of Organofluorine Compounds to the Agrochemical Industry by Ogawa, Yuta, Tokunaga, Etsuko, Kobayashi, Osamu, Hirai, Kenji, Shibata, Norio

“…Currently, more than 1,200 agrochemicals are listed and many of these are regularly used by farmers to generate the food supply to support the expanding global…”
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Defluorosilylation of fluoroarenes and fluoroalkanes by Cui, Benqiang, Jia, Shichong, Tokunaga, Etsuko, Shibata, Norio

“…Direct activation of carbon–fluorine bonds (C–F) to introduce the silyl or boryl groups and generate valuable carbon–silicon (C–Si) or carbon–boron (C–B) bonds…”
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N-Fluoro Ammonium salts of Cinchona Alkaloids in Enantioselective Electrophilic Fluorination by Shibata, Norio, Cahard, Dominique

“…From 2000, our two research groups independently and simultaneously designed and developed a novel family of electrophilic fluorinating reagents based on the…”
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Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination by Liang, Yumeng, Zhao, Zhengyu, Taya, Akihito, Shibata, Norio

“…We describe a novel reagent system to obtain acyl fluorides directly from three different functional group precursors: carboxylic acids, aldehydes, or…”
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Modular Synthesis of Medium-Sized Fluorinated and Nonfluorinated Heterocyclic Lactones by Sequential CN-Bond-Cleaving Ring Expansion under Pd Catalysis by Uno, Hiroto, Kawai, Koki, Shiro, Motoo, Shibata, Norio

“…Fluoro-functionalized heterocycles and medium-sized heterocycles are both attractive skeletons in medicinal chemistry. However, the construction of…”
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Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs by Zhu, Yi, Han, Jianlin, Wang, Jiandong, Shibata, Norio, Sodeoka, Mikiko, Soloshonok, Vadim A, Coelho, Jaime A. S, Toste, F. Dean

“…New methods for preparation of tailor-made fluorine-containing compounds are in extremely high demand in nearly every sector of chemical industry. The…”
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Catalyst-free carbosilylation of alkenes using silyl boronates and organic fluorides via selective C-F bond activation by Zhou, Jun, Jiang, Bingyao, Fujihira, Yamato, Zhao, Zhengyu, Imai, Takanori, Shibata, Norio

“…A regioselective carbosilylation of alkenes has emerged as a powerful strategy to access molecules with functionalized silylated alkanes, by incorporating…”
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Transition-metal-free silylboronate-mediated cross-couplings of organic fluorides with amines by Zhou, Jun, Zhao, Zhengyu, Shibata, Norio

“…C–N bond cross-couplings are fundamental in the field of organic chemistry. Herein, silylboronate-mediated selective defluorinative cross-coupling of organic…”
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Recent advancements in the synthesis of pentafluorosulfanyl (SF5)-containing heteroaromatic compounds by Das, Prajwalita, Tokunaga, Etsuko, Shibata, Norio

“…[Display omitted] •Synthesis of pentafluorosulfanyl-substituted heteroaromatics is reviewed.•Synthesis of pentafluorosulfanyl-substituted pyridines is…”
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Synthesis of Highly Functionalized 12-Membered Trifluoromethyl Heterocycles via a Nondecarboxylative Pd-Catalyzed [6 + 6] Annulation by Uno, Hiroto, Imai, Takanori, Harada, Kyosuke, Shibata, Norio

“…An efficient method for the construction of 12-membered heterocycles with a trifluoromethyl group (3) was achieved via a nondecarboxylative Pd-catalyzed [6 +…”
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A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues by Yamanaka, Satoshi, Horiuchi, Yuto, Matsuoka, Saya, Kido, Kohki, Nishino, Kohei, Maeno, Mayaka, Shibata, Norio, Kosako, Hidetaka, Sawasaki, Tatsuya

“…Proteolysis-targeting chimaeras (PROTACs) as well as molecular glues such as immunomodulatory drugs (IMiDs) and indisulam are drugs that induce interactions…”
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Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide by Furihata, Hirotake, Yamanaka, Satoshi, Honda, Toshiaki, Miyauchi, Yumiko, Asano, Atsuko, Shibata, Norio, Tanokura, Masaru, Sawasaki, Tatsuya, Miyakawa, Takuya

“…Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are…”
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Enantio‐, Diastereo‐ and Regioselective Synthesis of Chiral Cyclic and Acyclic gem‐Difluoromethylenes by Palladium‐Catalyzed [4+2] Cycloaddition by Uno, Hiroto, Kawai, Koki, Araki, Taichi, Shiro, Motoo, Shibata, Norio

“…gem‐Difluoromethylene moieties are attractive in medicinal chemistry due to their ability to mimic other more ubiquitous functional groups. Thus, effective…”
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Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers by Tokunaga, Etsuko, Yamamoto, Takeshi, Ito, Emi, Shibata, Norio

“…Twenty years after the thalidomide disaster in the late 1950s, Blaschke et al . reported that only the ( S )-enantiomer of thalidomide is teratogenic. However,…”
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Catalytic Trifluoromethylation of Aryl- and Vinylboronic Acids by 2‑Cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium Triflate by Arimori, Sadayuki, Shibata, Norio

“…Catalytic trifluoromethylation of aryl- and vinylboronic acids by 2-cyclopropyl-1-(trifluoromethyl)­benzo­[b]­thiophenium triflate is described. In the…”
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Novel Use of CF3SO2Cl for the Metal-Free Electrophilic Trifluoromethylthiolation by Chachignon, Hélène, Maeno, Mayaka, Kondo, Hiroya, Shibata, Norio, Cahard, Dominique

“…The regioselective trifluoromethylthiolation of indole derivatives was achieved under reductive conditions with trifluoromethanesulfonyl chloride as the…”
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Difluoromethylation of Terminal Alkynes by Fluoroform by Okusu, Satoshi, Tokunaga, Etsuko, Shibata, Norio

“…The difluoromethylation of terminal alkynes through the use of fluoroform as a source of difluorocarbene is described. The choice of solvents and bases was…”
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Catalytic Asymmetric Synthesis of Enantioenriched Heterocycles Bearing a CCF3 Stereogenic Center by Huang, Yi-Yong, Yang, Xing, Chen, Zhuo, Verpoort, Francis, Shibata, Norio

“…Given the important agricultural and medicinal application of optically pure heterocycles bearing a trifluoromethyl group at the stereogenic carbon center in…”
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