Search Results - "Shibata, Keitaro"

Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease by Shahpasand, Kourosh, Uemura, Isao, Saito, Taro, Asano, Tsunaki, Hata, Kenji, Shibata, Keitaro, Toyoshima, Yoko, Hasegawa, Masato, Hisanaga, Shin-Ichi

“…The microtubule-associated protein Tau is a major component of the neurofibrillary tangles that serve as a neuropathological hallmark of Alzheimer's disease…”
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Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth by Zamberlan, Margherita, Boeckx, Amandine, Muller, Florian, Vinelli, Federica, Ek, Olivier, Vianello, Caterina, Coart, Emeline, Shibata, Keitaro, Christian, Aurélie, Grespi, Francesca, Giacomello, Marta, Struman, Ingrid, Scorrano, Luca, Herkenne, Stéphanie

“…Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast…”
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Unidirectional cooperative binding of fimbrin actin-binding domain 2 to actin filament by Hosokawa, Naoki, Kuragano, Masahiro, Yoshino, Atsuki, Shibata, Keitaro, Uyeda, Taro Q.P., Tokuraku, Kiyotaka

“…Fimbrin forms bundles of parallel actin filaments in filopodia, but it remains unclear how fimbrin forms well-ordered bundles. To address this issue, we…”
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Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line by Noguchi, Masafumi, Kohno, Susumu, Pellattiero, Anna, Machida, Yukino, Shibata, Keitaro, Shintani, Norihito, Kohno, Takashi, Gotoh, Noriko, Takahashi, Chiaki, Hirao, Atsushi, Scorrano, Luca, Kasahara, Atsuko

“…Drug resistance limits the efficacy of chemotherapy and targeted cancer treatments, calling for the identification of druggable targets to overcome it. Here we…”
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Actin-binding domains mediate the distinct distribution of two Dictyostelium Talins through different affinities to specific subsets of actin filaments during directed cell migration by Tsujioka, Masatsune, Uyeda, Taro Q P, Iwadate, Yoshiaki, Patel, Hitesh, Shibata, Keitaro, Yumoto, Tenji, Yonemura, Shigenobu

“…Although the distinct distribution of certain molecules along the anterior or posterior edge is essential for directed cell migration, the mechanisms to…”
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K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins by Umeki, Nobuhisa, Shibata, Keitaro, Noguchi, Taro Q. P., Hirose, Keiko, Sako, Yasushi, Uyeda, Taro Q. P.

“…Mutation of the Lys-336 residue of actin to Ile (K336I) or Asp (K336E) causes congenital myopathy. To understand the effect of this mutation on the function of…”
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A single protofilament is sufficient to support unidirectional walking of dynein and kinesin by Shibata, Keitaro, Miura, Michi, Watanabe, Yuta, Saito, Kei, Nishimura, Atsuko, Furuta, Ken'ya, Toyoshima, Yoko Y

“…Cytoplasmic dynein and kinesin are two-headed microtubule motor proteins that move in opposite directions on microtubules. It is known that kinesin steps by a…”
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Actin binding domain of filamin distinguishes posterior from anterior actin filaments in migrating Dictyostelium cells by Shibata, Keitaro, Nagasaki, Akira, Adachi, Hiroyuki, Uyeda, Taro Q. P.

“…Actin filaments in different parts of a cell interact with specific actin binding proteins (ABPs) and perform different functions in a spatially regulated…”
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Elucidating how linear motor proteins impinge on mitochondrial morphology by Shibata, Keitaro, Scorrano, Luca

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Conformational diversity of dynactin sidearm and domain organization of its subunit p150 by Saito, Kei, Murayama, Takashi, Hata, Tomone, Kobayashi, Takuya, Shibata, Keitaro, Kazuno, Saiko, Fujimura, Tsutomu, Sakurai, Takashi, Toyoshima, Yoko Y

“…Dynactin is a principal regulator of the minus-end directed microtubule motor dynein. The sidearm of dynactin is essential for binding to microtubules and…”
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α- and β-Tubulin Lattice of the Axonemal Microtubule Doublet and Binding Proteins Revealed by Single Particle Cryo-Electron Microscopy and Tomography by Maheshwari, Aditi, Obbineni, Jagan Mohan, Bui, Khanh Huy, Shibata, Keitaro, Toyoshima, Yoko Y., Ishikawa, Takashi

“…Microtubule doublet (MTD) is the main skeleton of cilia/flagella. Many proteins, such as dyneins and radial spokes, bind to MTD, and generate or regulate…”
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Circular orientation fluorescence emitter imaging (COFEI) of rotational motion of motor proteins by Sugawa, Mitsuhiro, Masaike, Tomoko, Mikami, Nagisa, Yamaguchi, Shin, Shibata, Keitaro, Saito, Kei, Fujii, Fumihiko, Toyoshima, Yoko Y., Nishizaka, Takayuki, Yajima, Junichiro

“…Single-molecule fluorescence polarization technique has been utilized to detect structural changes in biomolecules and intermolecular interactions. Here we…”
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Single Protofilament is Enough to Support Unidirectional Walking of Cytoplasmic Dynein by Shibata, Keitaro, Miura, Michi, Watanabe, Yuta, Nishimura, Atsuko, Edamatsu, Masaki, Toyoshima, Yoko Y.

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Direction and speed of microtubule movements driven by kinesin motors arranged on catchin thick filaments by Taba, Toshiki, Edamatsu, Masaki, Toba, Shiori, Shibata, Keitaro, Imafuku, Yasuhiro, Toyoshima, Yoko Yano, Tawada, Katsuhisa, Yamada, Akira

“…Conventional kinesin (Kinesin‐1) is a microtubule‐based molecular motor that supports intracellular vesicle/organelle transport in various eukaryotic cells. To…”
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