Search Results - "Shi, Zhenqi"

Phase-appropriate Application of Process Analytical Technology for Early Pharmaceutical Development of Oral Solid Dosage Forms—the Case Study of Uniformity Screening of Dosage Units and Blends by Razvi, Sayyeda Zeenat, Ma, Shengli, Zhong, Qiqing, Muliadi, Ariel, Shi, Zhenqi (Pete)

“…Process analytical technology (PAT) in late-stage drug product development is typically used for real-time process monitoring, in-process control, and…”
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Salinity and high pH reduce denitrification rates by inhibiting denitrifying gene abundance in a saline-alkali soil by Pan, Yongchun, She, Dongli, Shi, Zhenqi, Cao, Taohong, Xia, Yongqiu, Shan, Jun

“…Denitrification, as the main nitrogen (N) removal process in farmland drainage ditches in coastal areas, is significantly affected by saline-alkali conditions…”
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Do biochar and polyacrylamide have synergistic effect on net denitrification and ammonia volatilization in saline soils? by Pan, Yongchun, She, Dongli, Shi, Zhenqi, Chen, Xinyi, Xia, Yongqiu

“…Salt-affected soils have poor structure and physicochemical properties, which affect soil nitrogen cycling process closely related to the environment, such as…”
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Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis by Li, Yuyu, Shi, Zhenqi, Jules, Joel, Chen, Shenyuan, Kesterson, Robert A, Zhao, Dongfeng, Zhang, Ping, Feng, Xu

“…ABSTRACT Upon receptor activator of NF‐κB ligand (RANKL) binding, RANK promotes osteoclast formation through the recruitment of tumor necrosis factor (TNF)…”
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Dissolved Nitrous Oxide in Shallow-Water Ecosystems under Saline-Alkali Environment by Du, Qianwen, She, Dongli, Pan, Yongchun, Shi, Zhenqi, Abulaiti, Alimu

“…The problem of global warming is becoming more and more serious. N2O is a potent greenhouse gas. Most current studies on dissolved N2O concentration have…”
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Application of Monte Carlo simulation-based photon migration for enhanced understanding of near-infrared (NIR) diffuse reflectance. Part I: Depth of penetration in pharmaceutical materials by Shi, Zhenqi, Anderson, Carl A

“…This is the first of a series of articles applying Monte Carlo simulation-based photon migration to enhance understanding of near-infrared (NIR) diffuse…”
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scHiCyclePred: a deep learning framework for predicting cell cycle phases from single-cell Hi-C data using multi-scale interaction information by Wu, Yingfu, Shi, Zhenqi, Zhou, Xiangfei, Zhang, Pengyu, Yang, Xiuhui, Ding, Jun, Wu, Hao

“…The emergence of single-cell Hi-C (scHi-C) technology has provided unprecedented opportunities for investigating the intricate relationship between cell cycle…”
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Pharmaceutical applications of separation of absorption and scattering in near-infrared spectroscopy (NIRS) by Shi, Zhenqi, Anderson, Carl A

“…The number of near-infrared (NIR) spectroscopic applications in the pharmaceutical sciences has grown significantly in the last decade. Despite its widespread…”
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Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain by Zhang, Qizhi, Jiang, Xinguo, Jiang, Wenming, Lu, Wei, Su, Lina, Shi, Zhenqi

“…The purpose of this study was to improve the solubility and enhance the brain uptake of nimodipine (NM) in an o/w microemulsion, which was suitable for…”
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Process characterization of powder blending by near-infrared spectroscopy: Blend end-points and beyond by Shi, Zhenqi, Cogdill, Robert P., Short, Steve M., Anderson, Carl A.

“…The purpose of this paper is to utilize near-infrared (NIR) spectroscopy to characterize powder blending in-line. A multivariate model-based approach was used…”
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Scattering Orthogonalization of Near-Infrared Spectra for Analysis of Pharmaceutical Tablets by Shi, Zhenqi, Anderson, Carl A

“…The paper explores scattering orthogonalization as a preprocessing technique to reduce physical interference and maintain chemical information in near-infrared…”
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Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts by Ashley, Jason W, Shi, Zhenqi, Zhao, Haibo, Li, Xingsheng, Kesterson, Robert A, Feng, Xu

“…CD68 is a member of the lysosome associated membrane protein (LAMP) family that is restricted in its expression to cells of the monocyte/macrophage lineage…”
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Niclosamide and its derivative DK‐520 inhibit RANKL‐induced osteoclastogenesis by Jiao, Yurui, Chen, Chenglong, Hu, Xijian, Feng, Xu, Shi, Zhenqi, Cao, Jie, Li, Qing, Zhu, Yikun

“…DK‐520 is an acyl derivative of Niclosamide that exhibits a significant increase in both the plasma concentration and bioavailability. Like Niclosamide, DK‐520…”
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Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: A novel mechanism mediating its blockade of osteoclastogenesis by Cheng, Jing, Liu, Jianzhong, Shi, Zhenqi, Xu, Duorong, Luo, Shaokai, Siegal, Gene P., Feng, Xu, Wei, Shi

“…Interleukin‐4 (IL‐4) is an important immune regulatory protein that possesses potent anti‐osteoclastogenic properties, and does so via the transcription factor…”
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Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis by Zhao, Dongfeng, Shi, Zhenqi, Warriner, Amy H, Qiao, Ping, Hong, Huixian, Wang, Yongjun, Feng, Xu

“…Thiazolidinediones are synthetic peroxisome proliferator-activated receptor γ agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that…”
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Application of Monte Carlo simulation-based photon migration for enhanced understanding of near-infrared (NIR) diffuse reflectance. Part II: Photon radial diffusion in NIR chemical images by Shi, Zhenqi, Anderson, Carl A

“…This is the second of a series of articles applying Monte Carlo simulation-based photon migration as a means of enhancing understanding of near-infrared (NIR)…”
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A novel sample selection strategy by near-infrared spectroscopy-based high throughput tablet tester for content uniformity in early-phase pharmaceutical product development by Shi, Zhenqi, Hermiller, James G, Gunter, Thomas Z, Zhang, Xiaoyu, Reed, Dave E

“…This article proposes a new sample selection strategy to simplify the traditional content uniformity (CU) test in early research and development (R&D) with…”
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Structural Interpretation in Composite Systems Using Powder X-ray Diffraction: Applications of Error Propagation to the Pair Distribution Function by Moore, Michael D, Shi, Zhenqi, Wildfong, Peter L. D

“…Purpose To develop a method for drawing statistical inferences from differences between multiple experimental pair distribution function (PDF) transforms of…”
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CTPredictor: A comprehensive and robust framework for predicting cell types by integrating multi-scale features from single-cell Hi-C data by Shi, Zhenqi, Wu, Hao

“…Single-cell Hi-C (scHi-C) has emerged as a powerful technology for deciphering cell-to-cell variability in three-dimensional (3D) chromatin organization,…”
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Thermal conductivity measurements for small molecule organic solid materials using modulated differential scanning calorimetry (MDSC) and data corrections for sample porosity by Lin, Yannan, Shi, Zhenqi, Wildfong, Peter L.D.

“…A method for measuring the thermal conductivity ( k) of small molecule organic solid materials using modulated differential scanning calorimetry (MDSC) is…”
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