Search Results - "Shi, Rubing"
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Stroke subtype-dependent synapse elimination by reactive gliosis in mice
Published in Nature communications (26-11-2021)“…The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we…”
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Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion
Published in Theranostics (2020)“…Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether…”
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Endothelial progenitor cell transplantation alleviated ischemic brain injury via inhibiting C3/C3aR pathway in mice
Published in Journal of cerebral blood flow and metabolism (01-12-2020)“…Endothelial progenitor cell transplantation is a potential therapeutic approach in brain ischemia. However, whether the therapeutic effect of endothelial…”
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Author Correction: Stroke subtype-dependent synapse elimination by reactive gliosis in mice
Published in Nature communications (28-02-2022)Get full text
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Extracellular vesicles from adipose-derived stem cells promote microglia M2 polarization and neurological recovery in a mouse model of transient middle cerebral artery occlusion
Published in Stem cell research & therapy (20-01-2022)“…Adipose-derived stem cells (ADSCs) and their extracellular vesicles (EVs) have therapeutic potential in ischemic brain injury, but the underlying mechanism is…”
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BK Channel-Mediated Microglial Phagocytosis Alleviates Neurological Deficit After Ischemic Stroke
Published in Frontiers in cellular neuroscience (01-07-2021)“…Microglial phagocytosis benefits neurological recovery after stroke. Large-conductance Ca2 + -activated K + currents are expressed in activated microglia, and…”
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Fingolimod Inhibits Inflammation but Exacerbates Brain Edema in the Acute Phases of Cerebral Ischemia in Diabetic Mice
Published in Frontiers in neuroscience (11-08-2020)“…Background and Purpose: Diabetes mellitus increases stroke incidence and mortality and hampers functional recovery after stroke. Fingolimod has been shown to…”
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Advanced rehabilitation in ischaemic stroke research
Published in Stroke and vascular neurology (01-08-2024)“…At present, due to the rapid progress of treatment technology in the acute phase of ischaemic stroke, the mortality of patients has been greatly reduced but…”
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ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut–Brain Axis
Published in Journal of agricultural and food chemistry (05-06-2019)“…Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective…”
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M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH
Published in Stroke (1970) (01-10-2023)“…BACKGROUND: Small extracellular vesicles (sEVs) derived from M2 microglia (M2-microglia–derived small extracellular vesicles [M2-sEVs]) contribute to central…”
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Blocking C3d + /GFAP + A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke
Published in Aging and disease (01-06-2022)“…Astrocytes play an essential role in the modulation of blood-brain barrier function. Neurological diseases induce the transformation of astrocytes into a…”
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Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice
Published in Journal of cerebral blood flow and metabolism (01-04-2023)“…The cellular redox state is essential for inhibiting ferroptosis. Progranulin (PGRN) plays an important role in maintaining the cellular redox state after…”
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Oligodendrocyte Precursor Cells Transplantation Improves Stroke Recovery via Oligodendrogenesis, Neurite Growth and Synaptogenesis
Published in Aging and disease (01-12-2021)“…Ischemic-induced white matter injury is strongly correlated with the poor neurological outcomes in stroke patients. The transplantation of oligodendrocyte…”
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Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke
Published in Theranostics (01-01-2024)“…Stroke induces metabolic changes in the body, and metabolites have become potential biomarkers for stroke. However, the specific metabolites involved in stroke…”
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Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice
Published in Neural regeneration research (10-07-2024)“…AAV-PHP.eB is an artificial adeno-associated virus (AAV) that crosses the blood-brain barrier and targets neurons more efficiently than other AAVs when…”
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Blocking C3[d.sup.+]/GFA[P.sup.+] A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke
Published in Aging and disease (01-06-2022)“…Astrocytes play an essential role in the modulation of blood-brain barrier function. Neurological diseases induce the transformation of astrocytes into a…”
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