Search Results - "Shi, Rocky"

Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs by Bosiljcic, Momir, Cederberg, Rachel A, Hamilton, Melisa J, LePard, Nancy E, Harbourne, Bryant T, Collier, Jenna L, Halvorsen, Elizabeth C, Shi, Rocky, Franks, S Elizabeth, Kim, Ada Y, Banáth, Judit P, Hamer, Mark, Rossi, Fabio M, Bennewith, Kevin L

“…Solid tumors produce proteins that can induce the accumulation of bone marrow-derived cells in various tissues, and these cells can enhance metastatic tumor…”
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Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma by Enfield, Katey S. S., Marshall, Erin A., Anderson, Christine, Ng, Kevin W., Rahmati, Sara, Xu, Zhaolin, Fuller, Megan, Milne, Katy, Lu, Daniel, Shi, Rocky, Rowbotham, David A., Becker-Santos, Daiana D., Johnson, Fraser D., English, John C., MacAulay, Calum E., Lam, Stephen, Lockwood, William W., Chari, Raj, Karsan, Aly, Jurisica, Igor, Lam, Wan L.

“…Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumor suppressor in many epithelial…”
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Transcriptional coactivator MED15 is required for beta cell maturation by Kadhim, Alex Z., Vanderkruk, Ben, Mar, Samantha, Dan, Meixia, Zosel, Katarina, Xu, Eric E., Spencer, Rachel J., Sasaki, Shugo, Cheng, Xuanjin, Sproul, Shannon L. J., Speckmann, Thilo, Nian, Cuilan, Cullen, Robyn, Shi, Rocky, Luciani, Dan S., Hoffman, Bradford G., Taubert, Stefan, Lynn, Francis C.

“…Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and…”
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Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer by Inoue, Yusuke, Nikolic, Ana, Farnsworth, Dylan, Shi, Rocky, Johnson, Fraser D, Liu, Alvin, Ladanyi, Marc, Somwar, Romel, Gallo, Marco, Lockwood, William W

“…Lineage transformation between lung cancer subtypes is a poorly understood phenomenon associated with resistance to treatment and poor patient outcomes. Here,…”
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells by Johnson, Fraser D., Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A., Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C., Zhang, Xu, Cheng, Grace S.W., Spencer Miko, Sandra E., de Rappard-Yuswack, Georgia, Sorensen, Poul H., Dixon, Scott J., Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B., Lockwood, William W.

“…Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their…”
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CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development by Melese, Etienne S., Franks, Elizabeth, Cederberg, Rachel A., Harbourne, Bryant T., Shi, Rocky, Wadsworth, Brennan J., Collier, Jenna L., Halvorsen, Elizabeth C., Johnson, Fraser, Luu, Jennifer, Oh, Min Hee, Lam, Vivian, Krystal, Gerald, Hoover, Shelley B., Raffeld, Mark, Simpson, R. Mark, Unni, Arun M., Lam, Wan L., Lam, Stephen, Abraham, Ninan, Bennewith, Kevin L., Lockwood, William W.

“…Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers…”
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Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment by Decotret, Lisa R, Shi, Rocky, Thomas, Kiersten N, Hsu, Manchi, Pallen, Catherine J, Bennewith, Kevin L

“…Organotypic cultures of murine brain slices are well-established tools in neuroscience research, including electrophysiology studies, modeling…”
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Characterizing the secretome of EGFR mutant lung adenocarcinoma by Luu, Jennifer K, Johnson, Fraser D, Jajarmi, Jana, Sihota, Tianna, Shi, Rocky, Lu, Daniel, Farnsworth, Dylan, Spencer, Sandra E, Negri, Gian Luca, Morin, Gregg B, Lockwood, William W

“…Lung cancer is the leading cause of cancer related death worldwide, mainly due to the late stage of disease at the time of diagnosis. Non-invasive biomarkers…”
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Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth by Cederberg, Rachel A., Franks, Sarah Elizabeth, Wadsworth, Brennan J., So, Alvina, Decotret, Lisa R., Hall, Michael G., Shi, Rocky, Hughes, Michael R., McNagny, Kelly M., Bennewith, Kevin L.

“…Metastatic breast cancer is challenging to effectively treat, highlighting the need for an improved understanding of host factors that influence metastatic…”
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MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression by Farnsworth, Dylan A., Inoue, Yusuke, Johnson, Fraser D., de Rappard-Yuswack, Georgia, Lu, Daniel, Shi, Rocky, Ma, Lok In Josephine, Mattar, Marissa S., Somwar, Romel, Ladanyi, Marc, Unni, Arun M., Lockwood, William W.

“…MEK inhibitors (MEKi) have limited efficacy in KRAS mutant lung adenocarcinoma (LUAD) patients, and this is attributed to both intrinsic and adaptive…”
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Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer by Firmino, Natalie S, Cederberg, Rachel A, Lee, Che-Min, Shi, Rocky, Wadsworth, Brennan J, Franks, S Elizabeth, Thomas, Kiersten N, Decotret, Lisa R, Bennewith, Kevin L

“…Hypoxia develops in germinal centers (GCs) induced by model antigens; however, it is unknown whether tumor-reactive GCs are also hypoxic. We identified GC…”
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A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic β-cells by Chaudhry, Ahsen, Shi, Rocky, Luciani, Dan S

“…Live-cell imaging of mitochondrial function and dynamics can provide vital insights into both physiology and pathophysiology, including of metabolic diseases…”
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Abstract PO-053: Targeting focal adhesions to limit radiation-induced glioblastoma cell invasion by Decotret, Lisa R., Shi, Rocky, Bennewith, Kevin L.

“…Abstract Introduction: Glioblastoma multiforme (GBM) is a grade IV brain tumor that is considered incurable with a median overall survival of 15 months. This…”
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Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response by Nagelberg, Amy L., Sihota, Tianna S., Chuang, Yu-Chi, Shi, Rocky, Chow, Justine L. M., English, John, MacAulay, Calum, Lam, Stephen, Lam, Wan L., Lockwood, William W.

“…Background Identification of driver mutations and development of targeted therapies has considerably improved outcomes for lung cancer patients. However,…”
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A Pipeline for 2D and 3D Confocal Analysis of Mitochondrial Morphology and Network Connectivity in β-cells by Shi, Rocky, Chaudhry, Ahsen, Luciani, Dan S.

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35 - A Pipeline for 2D and 3D Confocal Analysis of Mitochondrial Morphology and Network Connectivity in β-cells by Shi, Rocky, Chaudhry, Ahsen, Luciani, Dan S.

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Bcl-xl Limits Decompensation of Beta Cell Mitochondria During Chronic Exposure to High Glucose by Pasula, Daniel, Shi, Rocky, Shih, Alexis, Chaudhry, Ahsen, Vanderkruk, Ben, Hoffman, Brad, Luciani, Dan

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76 - Antiapoptotic Bcl-xL Preserves the Transcriptional, Morphological and Functional Integrity of β-Cell Mitochondria During Chronic Glucose Excess by Pasula, Daniel, Shi, Rocky, Shih, Alexis, Chaudry, Ahsen, Vanderkruk, Ben, Hoffman, Brad, Luciani, Dan S.

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Anti-Apoptotic Bcl-xL Limits Mitochondrial Dysregulation in β-cells during Prolonged Exposure to High Glucose by Pasula, Daniel J., Shi, Rocky, Shih, Alexis Z.L., Luciani, Dan S.

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162 - Anti-Apoptotic Bcl-xL Limits Mitochondrial Dysregulation in β-cells during Prolonged Exposure to High Glucose by Pasula, Daniel J., Shi, Rocky, Shih, Alexis Z.L., Luciani, Dan S.

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