Search Results - "Shi, Mengchen"
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Comparison of the binding interactions of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicides with humic acid: Insights from multispectroscopic techniques, DFT and 2D-COS-FTIR
Published in Ecotoxicology and environmental safety (01-07-2022)“…4-Hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor is one of the important herbicides to solve the problem of weed control. With the widespread and continued…”
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Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1 + regulatory B cell expansion
Published in Journal for immunotherapy of cancer (10-12-2018)“…Regulatory B (Breg) cells represent one of the B cell subsets that infiltrate solid tumors and exhibit distinct phenotypes in different tumor…”
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Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8+ exhausted-like T cells
Published in Nature communications (24-11-2023)“…Atezolizumab (anti-PD-L1) combined with bevacizumab (anti-VEGFA) is the first-line immunotherapy for advanced hepatocellular carcinoma (HCC), but the number of…”
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Evacetrapib Elicits Antitumor Effects on Colorectal Cancer by Inhibiting the Wnt/β-Catenin Signaling Pathway and Activating the JNK Signaling Pathway
Published in Biological & pharmaceutical bulletin (01-09-2022)“…Despite advances in colorectal cancer (CRC) treatment, most advanced CRC patients who experience disease progression after chemotherapy, targeted therapy, and…”
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Prothioconazole Stress Reduces Bacterial Richness and Alters Enzyme Activity in Soybean Rhizosphere
Published in Toxics (Basel) (25-09-2024)“…Prothioconazole (PTC) is currently a popular triazole fungicide. In recent years, as the use of PTC has increased, there has been growing concern about its…”
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Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection
Published in Applied microbiology and biotechnology (01-02-2020)“…Clonorchis sinensis ( C. sinensis ), an important fishborne zoonotic parasite threatening public health, is of major socioeconomic importance in epidemic…”
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Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma
Published in Journal of translational medicine (19-10-2023)“…Abstract Background Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA…”
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The storage stability of Bacillus subtilis spore displaying cysteine protease of Clonorchis sinensis and its effect on improving the gut microbiota of mice
Published in Applied microbiology and biotechnology (01-03-2021)“…Bacillus subtilis ( B. subtilis ) spore can serve as an ideal vehicle for expressing heterologous antigens, and elicit specific immune responses by oral…”
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Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I
Published in Journal of translational medicine (14-08-2024)“…Although immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer treatment, only a minority of colorectal cancer (CRC) patients respond…”
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HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11
Published in Biomedicine & pharmacotherapy (01-04-2024)“…Uncertainty exists regarding the mechanisms by which hypoxia-inducible factors (HIFs) control CD8+T-cell migration into tumor microenvironments. Here, we found…”
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Tumor derived exosomal ENTPD2 impair CD8 + T cell function in colon cancer through ATP-adenosine metabolism reprogramming
Published in Cell communication and signaling (16-05-2024)“…Extracellular ATP-AMP-adenosine metabolism plays a pivotal role in modulating tumor immune responses. Previous studies have shown that the conversion of ATP to…”
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Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer
Published in Biomolecules & biomedicine (01-12-2023)“…Apolipoprotein E (apoE) has previously been reported to play vital roles in tumor progression. However, the impact of apoE on colorectal cancer (CRC)…”
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Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate
Published in Parasites & vectors (07-03-2018)“…Clonorchiasis caused by Clonorchis sinensis has become increasingly prevalent in recent years. Effective prevention strategies are urgently needed to control…”
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Clonorchis sinensis adult-derived proteins elicit Th2 immune responses by regulating dendritic cells via mannose receptor
Published in PLoS neglected tropical diseases (05-03-2018)“…Clonorchis sinensis (C. sinensis) is the most widespread human liver fluke in East Asia including China and Korea. Clonorchiasis as a neglected tropical…”
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Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma
Published in Parasites & vectors (25-05-2017)“…Long-term infections by Clonorchis sinensis are associated with cholangitis, cholecystitis, liver fibrosis, cirrhosis, and even liver cancer. Molecules from…”
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Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2 + dyshomeostasis in hepatocarcinoma PLC cells
Published in PLoS neglected tropical diseases (01-11-2017)“…Numerous experimental and epidemiological studies have demonstrated a link between Clonorchis sinensis (C. sinensis) infestation and cholangiocarcinoma (CCA)…”
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Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis
Published in Parasites & vectors (17-06-2017)“…Liver fibrosis is an excessive wound-healing reaction that requires the participation of inflammatory cells and hepatic stellate cells (HSCs). The pathogenesis…”
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Sequence analysis and characterization of pyruvate kinase from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective efficacy against clonorchiasis
Published in Parasites & vectors (09-11-2017)“…Clonorchis sinensis, the causative agent of clonorchiasis, is classified as one of the most neglected tropical diseases and affects more than 15 million people…”
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Probabilistic human health risk assessment of trace elements exposure in crayfish
Published in Journal of food composition and analysis (01-08-2023)“…In this study, we collected 385 crayfish samples from five provinces (Hubei, Hunan, Anhui, Sichuan, and Jiangsu) of the Yangtze River Basin in China during…”
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Core–shell reduced graphene oxide/MnOx@carbon hollow nanospheres for high performance supercapacitor electrodes
Published in Chemical engineering journal (Lausanne, Switzerland : 1996) (01-04-2017)“…[Display omitted] •Reduced graphene oxide (RGO)/MnOx@carbon hollow nanospheres (HCNs) were designed.•RGO/MnOx@HCNs have hollow structure, high surface area,…”
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