Pediatric asthma control during the COVID‐19 pandemic: A systematic review and meta‐analysis

Background With the onset of the coronavirus disease 2019 (COVID‐19) pandemic, many experts expected that asthma‐associated morbidity because of severe acute respiratory syndrome coronavirus 2 infection would dramatically increase. However, some studies suggested that there was no apparent increasin...

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Bibliographic Details
Published in:	Pediatric pulmonology Vol. 57; no. 1; pp. 20 - 25
Main Authors:	Yang, Ze, Wang, Xiang, Wan, Xi‐gang, Wang, Meng‐lei, Qiu, Zong‐hua, Chen, Jia‐li, Shi, Man‐hao, Zhang, Shi‐yi, Xia, Yong‐liang
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-01-2022 John Wiley and Sons Inc
Subjects:	Asthma Asthma - epidemiology Asthma - prevention & control asthma control Child children Coronaviruses COVID-19 Emergency medical care Hospitalization Humans Meta-analysis Pandemics Review Reviews SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 systematic review and meta‐analysis COVID-19 asthma control children systematic review and meta-analysis
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Summary:	Background With the onset of the coronavirus disease 2019 (COVID‐19) pandemic, many experts expected that asthma‐associated morbidity because of severe acute respiratory syndrome coronavirus 2 infection would dramatically increase. However, some studies suggested that there was no apparent increasing in asthma‐related morbidity in children with asthma, it is even possible children may have improved outcomes. To understand the relationship between the COVID‐19 pandemic and asthma outcomes, we performed this article. Methods We searched PubMed, Embase, and Cochrane Library to find literature from December 2019 to June 2021 related to COVID‐19 and children's asthma control, among which results such as s, comments, letters, reviews, and case reports were excluded. The level of asthma control during the COVID‐19 pandemic was synthesized and discussed by outcomes of asthma exacerbation, emergency room visit, asthma admission, and childhood asthma control test (c‐ACT). Results A total of 22,159 subjects were included in 10 studies. Random effect model was used to account for the data. Compared with the same period before the COVID‐19 pandemic, asthma exacerbation reduced (odds ratio [OR] = 0.26, 95% confidence interval [CI] = [0.14–0.48], Z = 4.32, p < 0.0001), the odds of emergency room visit decreased as well (OR = 0.11, 95% CI = [0.04–0.26], Z = 4.98, p < 0.00001). The outcome of asthma admission showed no significant difference (OR = 0.84, 95% CI = [0.32–2.20], Z = 0.36, p = 0.72). The outcome of c‐ACT scores were not analyzed because of the different manifestations used. Overall, c‐ACT scores reduced during the pandemic. Conclusion Compared to the same period before the COVID‐19 pandemic, the level of asthma control has been significantly improved. We need to understand the exact factors leading to these improvements and find methods to sustain it.
Bibliography:	Ze Yang and Xiang Wang co‐first authors. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-4 content type line 23 ObjectType-Undefined-3
ISSN:	8755-6863 1099-0496
DOI:	10.1002/ppul.25736