Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges

Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges

In vitro generation of red blood cells (RBCs) has the potential to circumvent the shortfalls in global demand for blood for transfusion applications. The conventional approach for RBC generation has been from differentiation of hematopoietic stem cells (HSCs) derived from cord blood, adult bone marr...

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Bibliographic Details
Published in:Biotechnology advances Vol. 36; no. 8; pp. 2118 - 2128
Main Authors: Lee, Esmond, Sivalingam, Jaichandran, Lim, Zhong Ri, Chia, Gloryn, Shi, Low Gin, Roberts, Mackenna, Loh, Yuin-Han, Reuveny, Shaul, Oh, Steve Kah-Weng
Format: Journal Article
Language:English
Published: England Elsevier Inc 01-12-2018
Elsevier Science Ltd
Subjects:
Animals
Blood diseases
Blood transfusion
Blood transfusions
Bone marrow
Cell Culture Techniques
Cell Differentiation
Cord blood
Erythrocytes
Erythroid
Fetal Blood - cytology
Hematopoietic
Hematopoietic Stem Cells
Humans
Immortalized
Induced pluripotent stem cells
Induced Pluripotent Stem Cells - cytology
Leukocytes
Mice
Red blood cells
Stem cells
Transfusion Medicine
MCV
FDA
Hematopoietic
HiDEP
BM
MSCs
Red blood cells
Cord blood
iEP
Immortalized
HUDEP
EB
CB
hPSCs
HbA
RBCs
G6PDH
HSPCs
AIDS
CFSE
GMP
G-CSF
HbF
HBOC
hiPSCs
PB
Erythroid
MCH
Induced pluripotent stem cells
MCHC
cRBCs
HSCs
imERYPC
PK
hESCs
ATP
2,3 DPG
ImEry
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Summary:In vitro generation of red blood cells (RBCs) has the potential to circumvent the shortfalls in global demand for blood for transfusion applications. The conventional approach for RBC generation has been from differentiation of hematopoietic stem cells (HSCs) derived from cord blood, adult bone marrow or peripheral blood. More recently, RBCs have been generated from human induced pluripotent stem cells (hiPSCs) as well as from immortalized adult erythroid progenitors. In this review, we highlight the recent advances to RBC generation from these different approaches and discuss the challenges and new strategies that can potentially make large-scale in vitro generation of RBCs a feasible approach.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2018.09.006