Search Results - "Shi, Kesi"

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury by Yang, Biao, Zhang, Feng, Cheng, Feng, Ying, Liwei, Wang, Chenggui, Shi, Kesi, Wang, Jingkai, Xia, Kaishun, Gong, Zhe, Huang, Xianpeng, Yu, Cao, Li, Fangcai, Liang, Chengzhen, Chen, Qixin

“…Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such patients had to suffer irreversible loss of motor or sensory…”
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Direct Reprogramming in Bone and Joint Degenerative Diseases: Applications, Obstacles and Directions by Shi, Kesi, Li, Fangcai, Tao, Yiqing, Chen, Qixin

“…With a booming aging population worldwide, bone and joint degenerative diseases have gradually become a major public health focus, attracting extensive…”
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A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury by Wang, Chenggui, Wang, Min, Xia, Kaishun, Wang, Jingkai, Cheng, Feng, Shi, Kesi, Ying, Liwei, Yu, Chao, Xu, Haibin, Xiao, Shining, Liang, Chengzhen, Li, Fangcai, Lei, Bo, Chen, Qixin

“…The repair and motor functional recovery after spinal cord injury (SCI) remains a worldwide challenge. The inflammatory microenvironment is one of main…”
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A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair by Yang, Biao, Liang, Chengzhen, Chen, Di, Cheng, Feng, Zhang, Yuang, Wang, Shaoke, Shu, Jiawei, Huang, Xianpeng, Wang, Jingkai, Xia, Kaishun, Ying, Liwei, Shi, Kesi, Wang, Chenggui, Wang, Xuhua, Li, Fangcai, Zhao, Qian, Chen, Qixin

“…The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the biological microenvironment by filling the injured cavity area and…”
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Metabolic reprogramming: a new option for the treatment of spinal cord injury by Chen, Jiangjie, Chen, Jinyang, Yu, Chao, Xia, Kaishun, Yang, Biao, Wang, Ronghao, Li, Yi, Shi, Kesi, Zhang, Yuang, Xu, Haibin, Zhang, Xuesong, Wang, Jingkai, Chen, Qixin, Liang, Chengzhen

“…Spinal cord injuries impose a notably economic burden on society, mainly because of the severe after-effects they cause. Despite the ongoing development of…”
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Investigation of the causal relationship between osteocalcin and dementia: A Mendelian randomization study by Liu, Wangmi, Hu, Qiang, Zhang, Feng, Shi, Kesi, Wu, Jiayan

“…Basic medical studies have reported an improved effect of osteocalcin on cognition. We explored the causal link between osteocalcin and dementia via the…”
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Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy by Li, Yi, Zhang, Yuang, Tao, Yiqin, Huang, Xianpeng, Yu, Chao, Xu, Haibin, Chen, Jiangjie, Xia, Kaishun, Shi, Kesi, Zhang, Yongxiang, Wang, Jingkai, Shu, Jiawei, Cheng, Feng, Wang, Shaoke, Liang, Chengzhen, Li, Fangcai, Zhou, Xiaopeng, Chen, Qixin

“…Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for…”
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Thermosensitive hydrogel-based GPR124 delivery strategy for rebuilding blood-spinal cord barrier by Shu, Jiawei, Wang, Chenggui, Tao, Yiqing, Wang, Shaoke, Cheng, Feng, Zhang, Yuang, Shi, Kesi, Xia, Kaishun, Wang, Ronghao, Wang, Jingkai, Yu, Chao, Chen, Jiangjie, Huang, Xianpeng, Xu, Haibin, Zhou, Xiaopeng, Wu, Haobo, Liang, Chengzhen, Chen, Qixin, Yan, Shigui, Li, Fangcai

“…Spinal cord injury (SCI) causes blood-spinal cord barrier (BSCB) disruption, leading to secondary damage, such as hemorrhagic infiltration, inflammatory…”
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Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization by Yu, Chao, Zhao, Jing, Cheng, Feng, Chen, Jiangjie, Chen, Jinyang, Xu, Haibin, Shi, Kesi, Xia, Kaishun, Ding, Siwen, Wang, Kanbin, Wang, Ronghao, Chen, Yazhou, Li, Yi, Li, Hao, Chen, Qixin, Yu, Xiaohua, Shao, Fangwei, Liang, Chengzhen, Li, Fangcai

“…Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications in intervertebral disc…”
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Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury by Chen, Jian, Wang, Zhouguang, Zheng, ZengMing, Chen, Yu, Khor, Sinan, Shi, KeSi, He, ZiLi, Wang, Qingqing, Zhao, Yingzheng, Zhang, Hongyu, Li, Xiaokun, Li, Jiawei, Yin, Jiayu, Wang, Xiangyang, Xiao, Jian

“…Therapeutics used to treat central nervous system (CNS) injury were designed to repair neurites and inhibit cell apoptosis. Previous studies have shown that…”
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Development of Uveal Melanoma-Specific Aptamer for Potential Biomarker Discovery and Targeted Drug Delivery by Pan, Zhaoqi, Zhu, Hui, Zhang, Yibin, Liao, Qianling, Sun, Yiping, Wu, Ende, Wang, Yanan, Shi, Kesi, Zhang, Yikui, Chen, Lu, Ye, Mao, Wu, Wencan

“…Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. However, challenges in early diagnosis, high risk of liver metastasis, and…”
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Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury by Wang, Shaoke, Wang, Rui, Chen, Jiangjie, Yang, Biao, Shu, Jiawei, Cheng, Feng, Tao, Yiqing, Shi, Kesi, Wang, Chenggui, Wang, Jingkai, Xia, Kaishun, Zhang, Yuang, Chen, Qixin, Liang, Chengzhen, Tang, Jianbin, Li, Fangcai

“…Pharmaceutical treatments are critical for the acute and subacute phases of spinal cord injury (SCI) and significantly impact patients' prognoses. However,…”
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Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration by Huang, Xianpeng, Yu, Chao, Li, Fangcai, Liang, Chengzhen, Chen, Qixin, Xia, Kaishun, Wang, Chenggui, Ying, Liwei, Shi, Kesi, Cheng, Feng, Wang, Jingkai, Yang, Biao, Zhang, Yuang, Gong, Zhe

“…The intervertebral disc degeneration (IDD) with increasing aging mainly manifests as low back pain (LBP) accompanied with a loss of physical ability. These…”
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Enhancement of nucleus pulposus repair by glycoengineered adipose-derived mesenchymal cells by Ying, Liwei, Liang, Chengzhen, Zhang, Yujie, Wang, Jingkai, Wang, Chenggui, Xia, Kaishun, Shi, Kesi, Yu, Chao, Yang, Biao, Xu, Haibin, Zhang, Yuang, Shu, Jiawei, Huang, Xianpeng, Xing, Hongyuan, Li, Fangcai, Zhou, Xiaopeng, Chen, Qixin

“…Adipose-derived mesenchymal stem cells (ADSCs) are promising candidates for repairing degenerated intervertebral discs through multiple means, including: i…”
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Partial reprogramming strategy for intervertebral disc rejuvenation by activating energy switch by Cheng, Feng, Wang, Chenggui, Ji, Yufei, Yang, Biao, Shu, Jiawei, Shi, Kesi, Wang, Lulu, Wang, Shaoke, Zhang, Yuang, Huang, Xianpeng, Zhou, Xiaopeng, Xia, Kaishun, Liang, Chengzhen, Chen, Qixin, Li, Fangcai

“…Rejuvenation of nucleus pulposus cells (NPCs) in degenerative discs can reverse intervertebral disc degeneration (IDD). Partial reprogramming is used to…”
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Dedifferentiation-like reprogramming of degenerative nucleus pulposus cells into notochordal-like cells by defined factors by Zhang, Yuang, Liang, Chengzhen, Xu, Haibin, Li, Yi, Xia, Kaishun, Wang, Liyin, Huang, Xianpeng, Chen, Jiangjie, Shu, Jiawei, Cheng, Feng, Shi, Kesi, Wang, Jingkai, Tao, Yiqing, Wang, Shaoke, Zhang, Yongxiang, Li, Hao, Feng, Shoumin, Li, Fangcai, Zhou, Xiaopeng, Chen, Qixin

“…The extensive degeneration of functional somatic cells and the depletion of endogenous stem/progenitor populations present significant challenges to tissue…”
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Effects of Rhizoma Drynariae Cataplasm on Fracture Healing in a Rat Model of Osteoporosis by Guo, Weijun, Shi, Kesi, Xiang, Guangheng, Lu, Di, Dou, Haicheng, Xie, Chenglong, Chen, Long

“…BACKGROUND Osteoporosis is an increasingly prevalent disease characterized by decreased bone mass and deterioration of the bone microstructure, which…”
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A novel rat model of annulus fibrosus injury for intervertebral disc degeneration by Xu, Haibin, Zhang, Yuang, Zhang, Yujie, Yu, Chao, Xia, Kaishun, Cheng, Feng, Shi, Kesi, Huang, Xianpeng, Li, Yi, Chen, Jiangjie, Shu, Jiawei, Zhou, Xiaopeng, Tao, Yiqing, Liang, Chengzhen, Li, Fangcai, Chen, Qixin

“…In clinical practice, acute trauma and chronic degeneration of the annulus fibrosus (AF) can promote further degeneration of the intervertebral disc (IVD)…”
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An injectable recombinant human milk fat globule–epidermal growth factor 8–loaded copolymer system for spinal cord injury reduces inflammation through NF-κB and neuronal cell death by Gong, Zhe, Wang, Chenggui, Ni, Licheng, Ying, Liwei, Shu, Jiawei, Wang, Jingkai, Yu, Chao, Xia, Kaishun, Cheng, Feng, Shi, Kesi, Xu, Guoping, Yu, Qunfei, Shen, Jiafeng, Chen, Qixin, Li, Fangcai, Liang, Chengzhen

“…Spinal cord injury (SCI) is a common disease and a major cause of paralysis, carrying much burden around the world. Despite the progress made with growth…”
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Liraglutide activates autophagy via GLP-1R to improve functional recovery after spinal cord injury by Chen, Jian, Wang, Zhouguang, Mao, Yuqin, Zheng, Zengming, Chen, Yu, Khor, Sinan, Shi, Kesi, He, Zili, Li, Jiawei, Gong, Fanghua, Liu, Yanlong, Hu, Aiping, Xiao, Jian, Wang, Xiangyang

“…Therapeutics used to treat central nervous system (CNS) injury are designed to promote axonal regeneration and inhibit cell death. Previous studies have shown…”
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