Search Results - "Shi, Jack"

First-in-Human Phase I Study of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in Patients with Advanced Solid Malignancies by Beatty, Gregory L, O'Dwyer, Peter J, Clark, Jason, Shi, Jack G, Bowman, Kevin J, Scherle, Peggy A, Newton, Robert C, Schaub, Richard, Maleski, Janet, Leopold, Lance, Gajewski, Thomas F

“…Indoleamine 2,3-dioxygenase-1 (IDO1) catalyzes the degradation of tryptophan to N-formyl-kynurenine. Overexpressed in many solid malignancies, IDO1 can promote…”
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The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers by Shi, Jack G., Chen, Xuejun, Lee, Fiona, Emm, Thomas, Scherle, Peggy A., Lo, Yvonne, Punwani, Naresh, Williams, William V., Yeleswaram, Swamy

“…Baricitinib (also known as LY3009104 or INCB028050), a novel and potent small molecule inhibitor of Janus kinase family of enzymes (JAKs) with selectivity for…”
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Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis by Punwani, Naresh, PhD, Scherle, Peggy, PhD, Flores, Robert, BSN, Shi, Jack, PhD, Liang, Jinjin, PhD, Yeleswaram, Swamy, PhD, Levy, Richard, MD, Williams, William, MD, Gottlieb, Alice, MD, PhD

“…Background Janus-associated kinases (JAKs) are involved in signal transduction from a variety of cytokines implicated in the pathogenesis of psoriasis,…”
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Robustness and the evolution of length control strategies in the T3SS and flagellar hook by Nariya, Maulik K., Mallela, Abhishek, Shi, Jack J., Deeds, Eric J.

“…Bacterial cells construct many structures, such as the flagellar hook and the type III secretion system (T3SS) injectisome, that aid in crucial physiological…”
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A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)–only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer by Kristeleit, Rebecca, Davidenko, Irina, Shirinkin, Vadim, El-Khouly, Fatima, Bondarenko, Igor, Goodheart, Michael J., Gorbunova, Vera, Penning, Carol A., Shi, Jack G., Liu, Xiangdong, Newton, Robert C., Zhao, Yufan, Maleski, Janet, Leopold, Lance, Schilder, Russell J.

“…Indoleamine 2,3-dioxygenase-1 (IDO1) is a key regulator of immune tolerance in ovarian cancer. This study investigated efficacy and safety of the IDO1 enzyme…”
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Beyond private 5G networks: applications, architectures, operator models and technological enablers by Maman, Mickael, Calvanese-Strinati, Emilio, Dinh, Lam Ngoc, Haustein, Thomas, Keusgen, Wilhelm, Wittig, Sven, Schmieder, Mathis, Barbarossa, Sergio, Merluzzi, Mattia, Costanzo, Francesca, Sardellitti, Stefania, Klessig, Henrik, Kendre, Savita Vitthalrao, Munaretto, Daniele, Centenaro, Marco, di Pietro, Nicola, Liang, Shuo-Peng, Chih, Kuan-Yi, Luo, Jack Shi-Jie, Kao, Ling-Chih, Huang, Jiun-Cheng, Huang, Jen-Sheng, Wang, Tzu-Ya

“…Private networks will play a key role in 5G and beyond to enable smart factories with the required better deployment, operation and flexible usage of available…”
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The Pharmacokinetics, Pharmacodynamics, and Safety of Orally Dosed INCB018424 Phosphate in Healthy Volunteers by Shi, Jack G., Chen, Xuejun, McGee, Ryan F., Landman, Robert R., Emm, Thomas, Lo, Yvonne, Scherle, Peggy A., Punwani, Naresh G., Williams, William V., Yeleswaram, Swamy

“…INCB018424 phosphate, a potent inhibitor of JAK enzymes with selectivity for JAK1&2, is in development for the treatment of myelofibrosis (MF). The oral dose…”
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In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions by Zhang, Qiang, Zhang, Yan, Boer, Jason, Shi, Jack G, Hu, Peidi, Diamond, Sharon, Yeleswaram, Swamy

“…Epacadostat (EPAC) is a first-in-class, orally active inhibitor of the enzyme indoleamine 2,3-dioxygenase 1 and has demonstrated promising clinical activity…”
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Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050 by Fridman, Jordan S, Scherle, Peggy A, Collins, Robert, Burn, Timothy C, Li, Yanlong, Li, Jun, Covington, Maryanne B, Thomas, Beth, Collier, Paul, Favata, Margaret F, Wen, Xiaoming, Shi, Jack, McGee, Ryan, Haley, Patrick J, Shepard, Stacey, Rodgers, James D, Yeleswaram, Swamy, Hollis, Greg, Newton, Robert C, Metcalf, Brian, Friedman, Steven M, Vaddi, Kris

“…Inhibiting signal transduction induced by inflammatory cytokines offers a new approach for the treatment of autoimmune diseases such as rheumatoid arthritis…”
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Mathematical Model for Length Control by the Timing of Substrate Switching in the Type III Secretion System by Nariya, Maulik K, Israeli, Johnny, Shi, Jack J, Deeds, Eric J

“…Type III Secretion Systems (T3SS) are complex bacterial structures that provide gram-negative pathogens with a unique virulence mechanism whereby they grow a…”
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Population Pharmacokinetic and Pharmacodynamic Modeling of Epacadostat in Patients With Advanced Solid Malignancies by Shi, Jack G., Bowman, Kevin J., Chen, Xuejun, Maleski, Janet, Leopold, Lance, Yeleswaram, Swamy

“…Epacadostat (EPA, INCB024360) is a selective inhibitor of the enzyme indoleamine 2,3‐dioxygenase 1 (IDO1) and is being developed as an orally active…”
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The relevance of assessment of intestinal P-gp inhibition using digoxin as an in vivo probe substrate by Yeleswaram, Swamy, Shi, Jack G, Zhang, Yan

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The Effect of CYP3A4 Inhibition or Induction on the Pharmacokinetics and Pharmacodynamics of Orally Administered Ruxolitinib (INCB018424 Phosphate) in Healthy Volunteers by Shi, Jack G., Chen, Xuejun, Emm, Thomas, Scherle, Peggy A., McGee, Ryan F., Lo, Yvonne, Landman, Robert R., McKeever Jr, Edward G., Punwani, Naresh G., Williams, William V., Yeleswaram, Swamy

“…Ruxolitinib, a selective Janus kinase (JAK) 1&2 inhibitor in development for the treatment of myeloproliferative neoplasms, is primarily metabolized by CYP3A4…”
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Micromechanical model for self-organized secondary phase oxide nanorod arrays in epitaxial YBa2Cu3O7−δ films by Shi, Jack J., Wu, Judy Z.

“…A micromechanical model based on the theory of elasticity has been developed to study the configuration of self-assembled secondary phase oxide nanostructures…”
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Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans by Boer, Jason, Young-Sciame, Ruth, Lee, Fiona, Bowman, Kevin J, Yang, Xiaoqing, Shi, Jack G, Nedza, Frank M, Frietze, William, Galya, Laurine, Combs, Andrew P, Yeleswaram, Swamy, Diamond, Sharon

“…Epacadostat (EPA, INCB024360) is a first-in-class, orally active, investigational drug targeting the enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In Phase I…”
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Medical students’ experience of the hidden curriculum around primary care careers: a qualitative exploration of reflective diaries by Parekh, Ravi, Jones, Melvyn Mark, Singh, Surinder, Yuan, Jack Shi Jie, Chan, See Chai Carol, Mediratta, Saniya, Smith, Rhys, Gunning, Elinor, Gajria, Camille, Kumar, Sonia, Park, Sophie

“…ObjectivesPrimary healthcare internationally is facing a workforce crisis with fewer junior doctors choosing general practice (GP) as a career. In the UK, a…”
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Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation by Fridman, Jordan S., Scherle, Peggy A., Collins, Robert, Burn, Timothy, Neilan, Claire L., Hertel, Denise, Contel, Nancy, Haley, Patrick, Thomas, Beth, Shi, Jack, Collier, Paul, Rodgers, James D., Shepard, Stacey, Metcalf, Brian, Hollis, Gregory, Newton, Robert C., Yeleswaram, Swamy, Friedman, Steven M., Vaddi, Kris

“…JAKs are required for signaling initiated by several cytokines (e.g., IL-4, IL-12, IL-23, thymic stromal lymphopoietin (TSLP), and IFNγ) implicated in the…”
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Potential Underprediction of Warfarin Drug Interaction From Conventional Interaction Studies and Risk Mitigation: A Case Study With Epacadostat, an IDO1 Inhibitor by Shi, Jack G., Chen, Xuejun, Punwani, Naresh G., Williams, William V., Yeleswaram, Swamy

“…Drug–drug interaction (DDI) studies involving warfarin are typically conducted with subtherapeutic doses of warfarin to ensure the safety of volunteers…”
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Structural transition of secondary phase oxide nanorods in epitaxial YBa2Cu3O7−δ films on vicinal substrates by Shi, Jack J., Wu, Judy Z.

“…A theoretical study of a structural transition of secondary phase oxide nanorods in epitaxial YBa 2 Cu 3 O 7−δ films on vicinal SrTiO 3 substrates is…”
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Construction of a two-parameter empirical model of left ventricle wall motion using cardiac tagged magnetic resonance imaging data by Shi, Jack J, Alenezy, Mohammed, Smirnova, Irina V, Bilgen, Mehmet

“…A one-parameter model was previously proposed to characterize the short axis motion of the LV wall at the mid-ventricle level. The single parameter of this…”
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