Search Results - "Shi, Guoming"

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer by Wu, Di, Hu, Di, Chen, Hao, Shi, Guoming, Fetahu, Irfete S., Wu, Feizhen, Rabidou, Kimberlie, Fang, Rui, Tan, Li, Xu, Shuyun, Liu, Hang, Argueta, Christian, Zhang, Lei, Mao, Fei, Yan, Guoquan, Chen, Jiajia, Dong, Zhaoru, Lv, Ruitu, Xu, Yufei, Wang, Mei, Ye, Yong, Zhang, Shike, Duquette, Danielle, Geng, Songmei, Yin, Clark, Lian, Christine Guo, Murphy, George F., Adler, Gail K., Garg, Rajesh, Lynch, Lydia, Yang, Pengyuan, Li, Yiming, Lan, Fei, Fan, Jia, Shi, Yang, Shi, Yujiang Geno

“…Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening…”
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Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway by Xu, Minghao, Zhou, Chenhao, Weng, Jialei, Chen, Zhaoshuo, Zhou, Qiang, Gao, Jian, Shi, Guoming, Ke, Aiwu, Ren, Ning, Sun, Huichuan, Shen, Yinghao

“…Abstract Background Tumor-associated macrophages (TAMs), which form a large part of the tumor microenvironment, are normally regulated by metabolic…”
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Intratumor microbiome features reveal antitumor potentials of intrahepatic cholangiocarcinoma by Chai, Xiaoqiang, Wang, Jie, Li, Huanping, Gao, Chao, Li, Shuangqi, Wei, Chuanyuan, Huang, Jianhang, Tian, Yingming, Yuan, Jian, Lu, Jiacheng, Gao, Dongmei, Zheng, Yimin, Huang, Cheng, Zhou, Jian, Shi, Guoming, Ke, Aiwu, Liu, Feng, Fan, Jia, Cai, Jiabin

“…Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy with a high prevalence in China. This study aimed to characterize the ICC tissues' bacterial…”
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The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Based on FOLFIRI for Advanced Intrahepatic Cholangiocarcinoma as Second-Line and Successive Treatment: A Real-World Study by Huang, Peixin, Huang, Xiaoyong, Zhou, Yingting, Yang, Guohuan, Sun, Qiman, Shi, Guoming, Chen, Yi

“…Objective. Intrahepatic cholangiocarcinoma (iCCA) is a primary liver malignancy with a poor prognosis and limited treatment. Cisplatin with gemcitabine is used…”
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PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy by Zheng, Yimin, Wang, Yining, Lu, Zhou, Wan, Jinkai, Jiang, Lulu, Song, Danjun, Wei, Chuanyuan, Gao, Chao, Shi, Guoming, Zhou, Jian, Fan, Jia, Ke, Aiwu, Zhou, Lu, Cai, Jiabin

“…The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying…”
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Multi-Scale Simulation of Recrystallization during Rolling of Large 2219 Aluminum Alloy Rings by He, Fengyang, Ma, Xu, Ma, Ke, Ding, Yanhong, Shi, Guoming, Wang, Chengwu

“…2219 aluminum–copper alloy is a major material in launch vehicles transition rings. The study of dynamic recrystallization during its rolling and forming…”
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Prediction of Post-Operative Liver Dysfunction by Serum Markers of Liver Fibrosis in Hepatocellular Carcinoma by Shen, Yinghao, Shi, Guoming, Huang, Cheng, Zhu, Xiaodong, Chen, Si, Sun, Huichuan, Zhou, Jian, Fan, Jia

“…To investigate the role of biomarkers in predicting postoperative liver dysfunction in patients with hepatocellular carcinoma (HCC). A total of 200 patients…”
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Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity by Wang, Yuetong, Li, Qiaoming, Ding, Yahui, Luo, Chenfei, Yang, Jun, Wang, Na, Jiang, Ning, Yao, Tiange, Wang, Guohao, Shi, Guoming, Hou, Steven X.

“…The small G protein Arf1 has been identified as playing a selective role in supporting cancer stem cells (CSCs), making it an attractive target for cancer…”
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The association between monocytic myeloid-derived suppressor cells levels and the anti-tumor efficacy of anti-PD-1 therapy in NSCLC patients by Feng, Jiuxing, Chen, Shujing, Li, Shuangqi, Wu, Baitong, Lu, Jiacheng, Tan, Li, Li, Jiamin, Song, Yuanlin, Shi, Guoming, Shi, Yujiang Geno, Jiang, Jinjun

“…Monocytic myeloid-derived suppressor cells (M-MDSCs), granulocytic MDSC (G-MDSCs) and regulatory T cells (Tregs) inhibit adaptive anti-tumor immunity and…”
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BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma by Zhang, Pengfei, Dong, Zhaoru, Cai, Jiabin, Zhang, Chi, Shen, Zaozhuo, Ke, Aiwu, Gao, Dongmei, Fan, Jia, Shi, Guoming

“…Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that play an important role in chromatin remodeling and transcriptional regulation…”
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Lusutrombopag for thrombocytopenia in Chinese patients with chronic liver disease undergoing invasive procedures by Ding, Zhenbin, Wu, Hong, Zeng, Yongyi, Kuang, Ming, Yang, Wei, Meng, Zhiqiang, Chen, Yajin, Hao, Chunyi, Zou, Shubing, Sun, Huichuan, Liu, Chang, Lin, Kecan, Shi, Guoming, Wang, Xiaoying, Fu, Xiutao, Chen, Rongxin, Chen, Yi, Liang, Ruifang, Kano, Takeshi, Pan, Huiyan, Yang, Suna, Fan, Jia, Zhou, Jian

“…Purpose Probing efficacy and safety of lusutrombopag in Chinese chronic liver disease (CLD) and severe thrombocytopenia (PLT < 50 × 10 9 /L) patients…”
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Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B‐related hepatocellular carcinoma by Chai, Xiaoqiang, Guo, Jianfei, Dong, Ruizhao, Yang, Xuan, Deng, Chao, Wei, Chuanyuan, Xu, JiaJie, Han, Weiyu, Lu, Jiacheng, Gao, Chao, Gao, Dongmei, Huang, Cheng, Ke, Aiwu, Li, Shuangqi, Li, Huanping, Tian, Yingming, Gu, Zhongkai, Liu, Shuxian, Liu, Hang, Chen, Qilong, Liu, Feng, Zhou, Jian, Fan, Jia, Shi, Guoming, Wu, Feizhen, Cai, Jiabin

“…Lysine acetylation (Kac) as an important posttranslational modification of histones is essential for the regulation of gene expression in hepatocellular…”
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Apparent Diffusion Coefficient MRI Shows Association With Early Progression of Unresectable Intrahepatic Cholangiocarcinoma With Combined Targeted‐Immunotherapy by Sheng, Ruofan, Sun, Wei, Huang, Xiaoyong, Jin, Kaipu, Gao, Shanshan, Zeng, Mengsu, Wu, Dong, Shi, Guoming

“…Background Most intrahepatic cholangiocarcinomas (ICCs) are diagnosed at advanced stage with an extremely poor prognosis. For these patients, combining…”
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Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma by Cai, Jiabin, Chen, Lei, Zhang, Zhou, Zhang, Xinyu, Lu, Xingyu, Liu, Weiwei, Shi, Guoming, Ge, Yang, Gao, Pingting, Yang, Yuan, Ke, Aiwu, Xiao, Linlin, Dong, Ruizhao, Zhu, Yanjing, Yang, Xuan, Wang, Jiefei, Zhu, Tongyu, Yang, Deping, Huang, Xiaowu, Sui, Chengjun, Qiu, Shuangjian, Shen, Feng, Sun, Huichuan, Zhou, Weiping, Zhou, Jian, Nie, Ji, Zeng, Chang, Stroup, Emily Kunce, Zhang, Xu, Chiu, Brian C-H, Lau, Wan Yee, He, Chuan, Wang, Hongyang, Zhang, Wei, Fan, Jia

“…The lack of highly sensitive and specific diagnostic biomarkers is a major contributor to the poor outcomes of patients with hepatocellular carcinoma (HCC). We…”
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Contrast-enhanced MRI could predict response of systemic therapy in advanced intrahepatic cholangiocarcinoma by Sheng, Ruofan, Huang, Xiaoyong, Jin, Kaipu, Gao, Shanshan, Zeng, Mengsu, Wu, Dong, Shi, Guoming

“…Objective To investigate whether pre-treatment contrast-enhanced MRI could predict the therapeutic response of systemic treatment in advanced intrahepatic…”
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Ten-eleven translocation-2 inactivation restrains IL-10-producing regulatory B cells to enable antitumor immunity in hepatocellular carcinoma by Lu, Zhou, Liu, Ronghua, Wang, Yining, Jiao, Mengxia, Li, Zhongchen, Wang, Zhiqiang, Huang, Cheng, Shi, Guoming, Ke, Aiwu, Wang, Luman, Fu, Ying, Xia, Jie, Wen, Haoyu, Zhou, Jian, Wang, Xiaoying, Ye, Dan, Fan, Jia, Chu, Yiwei, Cai, Jiabin

“…IL-10-producing regulatory B cells (IL-10 + B cells), a dominant regulatory B cell (Breg) subset, foster tumor progression. However, the mechanisms underlying…”
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Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition) by Zhou, Jian, Sun, Huichuan, Wang, Zheng, Cong, Wenming, Wang, Jianhua, Zeng, Mengsu, Zhou, Weiping, Bie, Ping, Liu, Lianxin, Wen, Tianfu, Han, Guohong, Wang, Maoqiang, Liu, Ruibao, Lu, Ligong, Ren, Zhengang, Chen, Minshan, Zeng, Zhaochong, Liang, Ping, Liang, Changhong, Chen, Min, Yan, Fuhua, Wang, Wenping, Ji, Yuan, Yun, Jingping, Cai, Dingfang, Chen, Yongjun, Cheng, Wenwu, Cheng, Shuqun, Dai, Chaoliu, Guo, Wenzhi, Hua, Baojin, Huang, Xiaowu, Jia, Weidong, Li, Yaming, Li, Yexiong, Liang, Jun, Liu, Tianshu, Lv, Guoyue, Mao, Yilei, Peng, Tao, Ren, Weixin, Shi, Hongcheng, Shi, Guoming, Tao, Kaishan, Wang, Wentao, Wang, Xiaoying, Wang, Zhiming, Xiang, Bangde, Xing, Baocai, Xu, Jianming, Yang, Jiamei, Yang, Jianyong, Yang, Yefa, Yang, Yunke, Ye, Shenglong, Yin, Zhengyu, Zhang, Bixiang, Zhang, Boheng, Zhang, Leida, Zhang, Shuijun, Zhang, Ti, Zhao, Yongfu, Zheng, Honggang, Zhu, Jiye, Zhu, Kangshun, Liu, Rong, Shi, Yinghong, Xiao, Yongsheng, Dai, Zhi, Teng, Gaojun, Cai, Jianqiang, Wang, Weilin, Cai, Xiujun, Li, Qiang, Shen, Feng, Qin, Shukui, Dong, Jiahong, Fan, Jia

“…Background: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and the second leading cause of…”
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Two stage, multi-center trial of cadonilimab and LM-302 for patients with CLDN18.2+ biliary tract cancer (BTC) that failed chemotherapy and PD-(L)1 antibody (ZSAB-Calm) by Fan, Jia, Zhou, Jian, Shi, Guoming, Huang, Xiaoyong, Gao, Qiang, Liang, Fei, Ren, Ning, Shi, Yinghong, Yi, Yong, Wang, Zheng, Yu, Yiyi, Hu, Zhiqiang, Hou, Yingyong, Chen, Yi, Hu, Zhiqiu, Lu, Pinxiang, Chen, Zhen

“…e16152 Background: BTC is a lethal disease with limited effective treatments, especially for those who have failed immune checkpoint inhibitors (ICIs) plus…”
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Clinical outcomes from a phase I clinical trial of a novel oncolytic virus VG161 in patients with hepatocellular carcinoma (HCC) refractory after 2 prior lines of therapy including checkpoint inhibitors (CPI) by Shen, Yinan, Liang, Xingmei, Jin, Xinyan, Tan, Qian, Zhao, Ronghua, Wei, Guyue, Fang, Tian, Li, Yuwei, Wang, Lei, Rahimian, Shah, Ding, Jun, Jia, William, Singh, Manu, Murad, Yanal, Huang, Maoliang, Zhang, Yuntao, Shi, Guoming, Kaufman, Howard L., Bai, Xueli, Liang, Tingbo

“…4105 Background: This study aims to investigate the safety and anti-tumor activity of VG161 expressing IL12, IL15/IL15 receptor α unit, and PD-L1 blocking…”
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TET2 promotes anti‐tumor immunity by governing G‐MDSCs and CD8+ T‐cell numbers by Li, Shuangqi, Feng, Jiuxing, Wu, Feizhen, Cai, Jiabin, Zhang, Xinyu, Wang, Haikun, Fetahu, Irfete S, Iwanicki, Isabella, Ma, Dingailu, Hu, Tao, Liu, Hang, Wang, Bingjie, Shi, Guoming, Tan, Li, Shi, Yujiang Geno

“…The host immune response is a fundamental mechanism for attenuating cancer progression. Here we report a role for the DNA demethylase and tumor suppressor TET2…”
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