Search Results - "Shi, Cheng Jiang"

All-optical reconstruction of k-dependent transition dipole moment by solid harmonic spectra from ultrashort laser pulses by Zhao, Yi-Ting, Ma, Shu-Yan, Jiang, Shi-Cheng, Yang, Yu-Jun, Zhao, Xi, Chen, Ji-Gen

“…Band structure and transition dipole moment play important roles in high-order harmonic generation from solid materials. In this work we provide a new…”
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The Development Process: from SAHA to Hydroxamate HDAC Inhibitors with Branched CAP Region and Linear Linker by Yang, Feifei, Zhao, Na, Hu, Yunjie, Jiang, Cheng‐Shi, Zhang, Hua

“…Histone deacetylases (HDACs) belong to a group of epigenetic regulatory enzymes that participate in modulating the acetylation level of histone lysine residues…”
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Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades by Jiang, Cheng-shi, Liang, Lin-fu, Guo, Yue-wei

“…This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which…”
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Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities by Yang, Feifei, Zhao, Na, Song, Jiali, Zhu, Kongkai, Jiang, Cheng-Shi, Shan, Peipei, Zhang, Hua

“…A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a…”
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Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms by Jiang, Cheng-Shi, Müller, Werner E. G, Schröder, Heinz C, Guo, Yue-Wei

“…An examination of marine organisms with disulfide- and multisulfide-containing metabolites is presented. Polysulfides from various marine organisms exhibit…”
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Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones by Yan, Xue, Tang, Ying-De, Jiang, Cheng-Shi, Liu, Xigong, Zhang, Hua

“…The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope…”
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Recent Advances in Antimicrobial Nano-Drug Delivery Systems by Zong, Tong-Xin, Silveira, Ariane Pandolfo, Morais, José Athayde Vasconcelos, Sampaio, Marina Carvalho, Muehlmann, Luis Alexandre, Zhang, Juan, Jiang, Cheng-Shi, Liu, Shan-Kui

“…Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the…”
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Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008 by Bao, Jie, Zhai, Huijuan, Zhu, Kongkai, Yu, Jin-Hai, Zhang, Yuying, Wang, Yinyin, Jiang, Cheng-Shi, Zhang, Xiaoyong, Zhang, Yun, Zhang, Hua

“…Eight new 4-hydroxy-2-pyridone alkaloids arthpyrones D⁻K ( ⁻ ), along with two known analogues apiosporamide ( ) and arthpyrone B ( ), were isolated from a…”
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New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity by Bao, Jie, He, Fei, Yu, Jin-Hai, Zhai, Huijuan, Cheng, Zhi-Qiang, Jiang, Cheng-Shi, Zhang, Yuying, Zhang, Yun, Zhang, Xiaoyong, Chen, Guangying, Zhang, Hua

“…Five new chromone derivatives, arthones A⁻E ( ⁻ ), together with eight known biogenetically related cometabolites ( ⁻ ), were isolated from a deep-sea-derived…”
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Discovery of Novel Marine‐Derived Phidiandine/Lipoic Acid Hybrid as a Potential Anti‐Atherosclerosis Agent: Design, Synthesis and in Vitro/in Vivo Evaluation by Liu, Shu‐Jun, Zhong, Ying‐Nan, Cheng, Zhi‐Qiang, Meng, Ning, Zhang, Juan, Jiang, Cheng‐Shi

“…In the present study, a novel derivative, IOP‐LA, was prepared by hybridizing antioxidant lipoic acid (LA) and our recently reported antioxidative marine…”
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Discovery and Biological Evaluation of New Selective Acetylcholinesterase Inhibitors with Anti-Aβ Aggregation Activity through Molecular Docking-Based Virtual Screening by Liu, Guangpu, Jiao, Yang, Lin, Yongqiang, Hao, Haifang, Dou, Yanli, Yang, Juan, Jiang, Cheng-Shi, Chang, Ping

“…Discovery of novel multifunctional inhibitors targeting acetylcholinesterase (AChE) has becoming a hot spot in anti-Alzheimer’s disease (AD) drug development…”
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Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation by Jiang, Cheng-Shi, Ge, Yong-Xi, Cheng, Zhi-Qiang, Wang, Yin-Yin, Tao, Hong-Rui, Zhu, Kongkai, Zhang, Hua

“…In this study, a series of selective butyrylcholinesterase (BChE) inhibitors was designed and synthesized from the structural optimization of hit , a…”
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Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation by Jiang, Cheng-Shi, Ge, Yong-Xi, Cheng, Zhi-Qiang, Song, Jia-Li, Wang, Yin-Yin, Zhu, Kongkai, Zhang, Hua

“…Although the mechanism of Alzheimer’s disease (AD) is still not fully understood, the development of multifunctional AChE inhibitors remains a research focus…”
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Synthesis and evaluation of coumarin/piperazine hybrids as acetylcholinesterase inhibitors by Zhang, Juan, Jiang, Cheng-Shi

“…A series of new coumarin/piperazine hybrids were synthesized and evaluated for anticholinesterase activity. Among them, compounds 4d and 4t exhibited potent…”
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Arginine Methyltransferase 5 (PRMT5) Inhibitors with 3-(1H-benzo[d]imidazol- 2-yl)anilines Core Identified by Virtual Screening and Biological Evaluation by Zhang, Ying, Zhu, Kongkai, Zhang, Juan, Zhang, Jin-He, Song, Zhiling, Zhang, Xinlei, Liu, Shan-Kui, Jiang, Cheng-Shi

“…PRMT5 is a major enzyme responsible for the post-translational symmetric demethylation of protein arginine residues, which has been validated as an effective…”
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New Cembrane‐Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata by Lin, Na, Li, Heng, Wang, Jian‐Rong, Tang, Wei, Zheng, Ming‐Yue, Wang, Hong, Jiang, Cheng‐Shi, Guo, Yue‐Wei

“…Comprehensive Summary In the present study, nine new cembrane‐type diterpenoids, namely ximaonanolobatins A—I (1—9), together with six related known analogs…”
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Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy by Jiang, Cheng-Shi, Zhuang, Chun-Lin, Zhu, Kongkai, Zhang, Juan, Muehlmann, Luis Alexandre, Figueiró Longo, João Paulo, Azevedo, Ricardo Bentes, Zhang, Wen, Meng, Ning, Zhang, Hua

“…A new Keap1-Nrf2 protein-protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon…”
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Sinucrassins A—K, Casbane‐type Diterpenoids from the South China Sea Soft Coral Sinularia crassa by Wu, Meng‐Jun, Liu, Jiao, Wang, Jian‐Rong, Zhang, Juan, Wang, Hong, Jiang, Cheng‐Shi, Guo, Yue‐Wei

“…Main observation and conclusion A detailed chemical study on the Hainan soft coral Sinularia crass has resulted in the isolation and characterization of eleven…”
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Design, Synthesis, and Antiproliferative Evaluation of Novel Coumarin/2-Cyanoacryloyl Hybrids as Apoptosis Inducing Agents by Activation of Caspase-Dependent Pathway by Zhang, Yu-Ying, Zhang, Qian-Qian, Song, Jia-Li, Zhang, Liang, Jiang, Cheng-Shi, Zhang, Hua

“…A series of novel coumarin/2-cyanoacryloyl hybrids were prepared and evaluated for their in vitro anticancer activity. Among them, two analogs and showed…”
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Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors by Zhu, Kongkai, Song, Jia-Li, Tao, Hong-Rui, Cheng, Zhi-Qiang, Jiang, Cheng-Shi, Zhang, Hua

“…[Display omitted] •A potent PRMT5 inhibitor (4b14) was identified by combining key pharmacophores of formerly reported PRMT5 inhibitors.•The direct binding of…”
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