Search Results - "Shi, Aiai"
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CancerSEA: a cancer single-cell state atlas
Published in Nucleic acids research (08-01-2019)“…Abstract High functional heterogeneity of cancer cells poses a major challenge for cancer research. Single-cell sequencing technology provides an unprecedented…”
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CellMarker: a manually curated resource of cell markers in human and mouse
Published in Nucleic acids research (08-01-2019)“…Abstract One of the most fundamental questions in biology is what types of cells form different tissues and organs in a functionally coordinated fashion…”
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A comprehensive atlas of epigenetic regulators reveals tissue-specific epigenetic regulation patterns
Published in Epigenetics (31-12-2023)“…Epigenetic machinery contributes to gene regulation in eukaryotic species. However, the machinery including more than 600 epigenetic regulator (ER) genes…”
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EPRIM: An approach of identifying cancer immune-related epigenetic regulators
Published in Molecular therapy. Nucleic acids (12-03-2024)“…Epigenetic regulation contributes to the dysregulation of gene expression involved in cancer biology. Nevertheless, the roles of epigenetic regulators (ERs) in…”
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Dissecting cellular states of infiltrating microenvironment cells in melanoma by integrating single-cell and bulk transcriptome analysis
Published in BMC immunology (12-12-2023)“…Cellular states of different immune cells can affect the activity of the whole immune microenvironment. Here, leveraging reference profiles of microenvironment…”
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Decoding functional impact of epigenetic regulator mutations on ligand–receptor interaction perturbations for evaluation of cancer immunotherapy
Published in Journal of cellular and molecular medicine (01-09-2024)“…Cellular crosstalk mediated by ligand–receptor interactions largely complicates the tumour ecosystem, resulting in heterogeneous tumour microenvironments that…”
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LnChrom: a resource of experimentally validated lncRNA-chromatin interactions in human and mouse
Published in Database : the journal of biological databases and curation (01-01-2018)“…Long non-coding RNAs (lncRNAs) constitute an important layer of chromatin regulation that contributes to various biological processes and diseases. By…”
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Capturing functional long non-coding RNAs through integrating large-scale causal relations from gene perturbation experiments
Published in EBioMedicine (01-09-2018)“…Characterizing functions of long noncoding RNAs (lncRNAs) remains a major challenge, mostly due to the lack of lncRNA-involved regulatory relationships. A wide…”
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Optimizing prognosis-related key miRNA-target interactions responsible for cancer metastasis
Published in Oncotarget (12-12-2017)“…Increasing evidence suggests that the abnormality of microRNAs (miRNAs) and their downstream targets is frequently implicated in the pathogenesis of human…”
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Capturing functional long non-coding RNAs through integrating large-scale causal relations from gene perturbation experimentsResearch in context
Published in EBioMedicine (01-09-2018)“…Characterizing functions of long noncoding RNAs (lncRNAs) remains a major challenge, mostly due to the lack of lncRNA-involved regulatory relationships. A wide…”
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