Search Results - "Sheward, Daniel"

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction by Hanke, Leo, Vidakovics Perez, Laura, Sheward, Daniel J., Das, Hrishikesh, Schulte, Tim, Moliner-Morro, Ainhoa, Corcoran, Martin, Achour, Adnane, Karlsson Hedestam, Gunilla B., Hällberg, B. Martin, Murrell, Ben, McInerney, Gerald M.

“…SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing…”
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Sensitivity of the SARS-CoV-2 BA.2.86 variant to prevailing neutralising antibody responses by Sheward, Daniel J, Yang, Yiqiu, Westerberg, Michelle, Öling, Sofia, Muschiol, Sandra, Sato, Kenta, Peacock, Thomas P, Karlsson Hedestam, Gunilla B, Albert, Jan, Murrell, Ben

“…After a prolonged period of near-complete global dominance of the recombinant XBB family of SARS-CoV-2 lineages, a substantially mutated sublineage of BA.2 has…”
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Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies by Sheward, Daniel J, Kim, Changil, Fischbach, Julian, Sato, Kenta, Muschiol, Sandra, Ehling, Roy A, Björkström, Niklas K, Hedestam, Gunilla B Karlsson, Reddy, Sai T, Albert, Jan, Peacock, Thomas P, Murrell, Ben

“…Here we report the sensitivity of emerging omicron sublineages BA.2.75.2, BA.4.6, and BA.2.10.4 to neutralisation by a panel of clinically relevant and…”
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Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape by Moore, Penny L, Gray, Elin S, Wibmer, C Kurt, Bhiman, Jinal N, Nonyane, Molati, Sheward, Daniel J, Hermanus, Tandile, Bajimaya, Shringkhala, Tumba, Nancy L, Abrahams, Melissa-Rose, Lambson, Bronwen E, Ranchobe, Nthabeleng, Ping, Lihua, Ngandu, Nobubelo, Karim, Quarraisha Abdool, Karim, Salim S Abdool, Swanstrom, Ronald I, Seaman, Michael S, Williamson, Carolyn, Morris, Lynn

“…A minority of HIV-1–infected individuals develop broadly neutralizing antibodies, which are considered an important goal of many HIV vaccine strategies. Moore…”
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Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study by Sheward, Daniel J, Kim, Changil, Ehling, Roy A, Pankow, Alec, Castro Dopico, Xaquin, Dyrdak, Robert, Martin, Darren P, Reddy, Sai T, Dillner, Joakim, Karlsson Hedestam, Gunilla B, Albert, Jan, Murrell, Ben

“…The SARS-CoV-2 omicron (B.1.1.529) variant, which was first identified in November, 2021, spread rapidly in many countries, with a spike protein highly…”
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Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2 by Custódio, Tânia F., Das, Hrishikesh, Sheward, Daniel J., Hanke, Leo, Pazicky, Samuel, Pieprzyk, Joanna, Sorgenfrei, Michèle, Schroer, Martin A., Gruzinov, Andrey Yu, Jeffries, Cy M., Graewert, Melissa A., Svergun, Dmitri I., Dobrev, Nikolay, Remans, Kim, Seeger, Markus A., McInerney, Gerald M., Murrell, Ben, Hällberg, B. Martin, Löw, Christian

“…The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic neutralizing antibodies constitute a key short-to-medium term approach to…”
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Evasion of neutralising antibodies by omicron sublineage BA.2.75 by Sheward, Daniel J, Kim, Changil, Fischbach, Julian, Muschiol, Sandra, Ehling, Roy A, Björkström, Niklas K, Hedestam, Gunilla B Karlsson, Reddy, Sai T, Albert, Jan, Peacock, Thomas P, Murrell, Ben

“…G446S has been predicted to be a site of potential escape from antibodies elicited by current vaccines that still neutralise omicron.5 Furthermore, it has been…”
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DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice by Szurgot, Inga, Hanke, Leo, Sheward, Daniel J., Vidakovics, Laura Perez, Murrell, Ben, McInerney, Gerald M., Liljeström, Peter

“…The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made the urgent development of scalable vaccines to prevent coronavirus…”
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Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster in Sweden by Marking, Ulrika, Bladh, Oscar, Aguilera, Katherina, Yang, Yiqiu, Greilert Norin, Nina, Blom, Kim, Hober, Sophia, Klingström, Jonas, Havervall, Sebastian, Åberg, Mikael, Sheward, Daniel J, Thålin, Charlotte

“…Participants, who were health-care workers vaccinated according to national recommendations, were enrolled through our ongoing observational COVID-19 Immunity…”
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Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs by Moliner-Morro, Ainhoa, J Sheward, Daniel, Karl, Vivien, Perez Vidakovics, Laura, Murrell, Ben, McInerney, Gerald M, Hanke, Leo

“…Multivalent antibody constructs have a broad range of clinical and biotechnological applications. Nanobodies are especially useful as components for…”
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A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo by Hanke, Leo, Das, Hrishikesh, Sheward, Daniel J., Perez Vidakovics, Laura, Urgard, Egon, Moliner-Morro, Ainhoa, Kim, Changil, Karl, Vivien, Pankow, Alec, Smith, Natalie L., Porebski, Bartlomiej, Fernandez-Capetillo, Oscar, Sezgin, Erdinc, Pedersen, Gabriel K., Coquet, Jonathan M., Hällberg, B. Martin, Murrell, Ben, McInerney, Gerald M.

“…Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential…”
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Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages by Chernyshev, Mark, Sakharkar, Mrunal, Connor, Ruth I., Dugan, Haley L., Sheward, Daniel J., Rappazzo, C. G., Stålmarck, Aron, Forsell, Mattias N. E., Wright, Peter F., Corcoran, Martin, Murrell, Ben, Walker, Laura M., Karlsson Hedestam, Gunilla B.

“…Vaccination of SARS-CoV-2 convalescent individuals generates broad and potent antibody responses. Here, we isolate 459 spike-specific monoclonal antibodies…”
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Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies by Pushparaj, Pradeepa, Nicoletto, Andrea, Sheward, Daniel J., Das, Hrishikesh, Castro Dopico, Xaquin, Perez Vidakovics, Laura, Hanke, Leo, Chernyshev, Mark, Narang, Sanjana, Kim, Sungyong, Fischbach, Julian, Ekström, Simon, McInerney, Gerald, Hällberg, B. Martin, Murrell, Ben, Corcoran, Martin, Karlsson Hedestam, Gunilla B.

“…The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH…”
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Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape by Wibmer, Constantinos Kurt, Gorman, Jason, Ozorowski, Gabriel, Bhiman, Jinal N, Sheward, Daniel J, Elliott, Debra H, Rouelle, Julie, Smira, Ashley, Joyce, M Gordon, Ndabambi, Nonkululeko, Druz, Aliaksandr, Asokan, Mangai, Burton, Dennis R, Connors, Mark, Abdool Karim, Salim S, Mascola, John R, Robinson, James E, Ward, Andrew B, Williamson, Carolyn, Kwong, Peter D, Morris, Lynn, Moore, Penny L

“…A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an…”
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HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies by Sheward, Daniel J, Hermanus, Tandile, Murrell, Ben, Garrett, Nigel, Abdool Karim, Salim S, Morris, Lynn, Moore, Penny L, Williamson, Carolyn

“…Induction of broadly neutralizing antibodies (bNAbs) to HIV and other diverse pathogens will likely require the use of multiple immunogens. An understanding of…”
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SARS-CoV-2 evolution in the Omicron era by Roemer, Cornelius, Sheward, Daniel J., Hisner, Ryan, Gueli, Federico, Sakaguchi, Hitoshi, Frohberg, Nicholas, Schoenmakers, Josette, Sato, Kenta, O’Toole, Áine, Rambaut, Andrew, Pybus, Oliver G., Ruis, Christopher, Murrell, Ben, Peacock, Thomas P.

“…Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and…”
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Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice by Wørzner, Katharina, Sheward, Daniel J., Schmidt, Signe Tandrup, Hanke, Leo, Zimmermann, Julie, McInerney, Gerald, Karlsson Hedestam, Gunilla B., Murrell, Ben, Christensen, Dennis, Pedersen, Gabriel Kristian

“…SARS-CoV-2 has caused a global pandemic, infecting millions of people. A safe, effective vaccine is urgently needed and remains a global health priority…”
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Degenerate Primer IDs and the Birthday Problem by Sheward, Daniel J, Murrell, Ben, Williamson, Carolyn

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Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop by MOORE, Penny L, GRAY, Elin S, SIBEKO, Sengeziwe, MLISANA, Koleka, ABDOOL KARIM, Salim S, WILLIAMSON, Carolyn, PINTER, Abraham, MORRIS, Lynn, SHEWARD, Daniel, MADIGA, Maphuti, RANCHOBE, Nthabeleng, ZHONG LAI, HONNEN, William J, NONYANE, Molati, TUMBA, Nancy, HERMANUS, Tandile

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth by Sheward, Daniel J., Marais, Jinny, Bekker, Valerie, Murrell, Ben, Eren, Kemal, Bhiman, Jinal N., Nonyane, Molati, Garrett, Nigel, Woodman, Zenda L., Abdool Karim, Quarraisha, Abdool Karim, Salim S., Morris, Lynn, Moore, Penny L., Williamson, Carolyn

“…Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine…”
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