Search Results - "Shewach, Donna S"

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development by Bester, Assaf C., Roniger, Maayan, Oren, Yifat S., Im, Michael M., Sarni, Dan, Chaoat, Malka, Bensimon, Aaron, Zamir, Gideon, Shewach, Donna S., Kerem, Batsheva

“…Chromosomal instability in early cancer stages is caused by stress on DNA replication. The molecular basis for replication perturbation in this context is…”
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Antimetabolite Radiosensitizers by Shewach, Donna S, Lawrence, Theodore S

“…Radiosensitization with antimetabolites has improved clinical outcome for patients with solid malignancies, especially cancers of the GI tract, cervix, and…”
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Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells by Mannava, Sudha, Grachtchouk, Vladimir, Wheeler, Linda J., Im, Michael, Zhuang, Dazhong, Slavina, Elena G., Mathews, Christopher K., Shewach, Donna S., Nikiforov, Mikhail A.

“…To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human metastatic melanoma lines via…”
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Folate levels modulate oncogene‐induced replication stress and tumorigenicity by Lamm, Noa, Maoz, Karin, Bester, Assaf C, Im, Michael M, Shewach, Donna S, Karni, Rotem, Kerem, Batsheva

“…Chromosomal instability in early cancer stages is caused by replication stress. One mechanism by which oncogene expression induces replication stress is to…”
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Short Hairpin RNA Suppression of Thymidylate Synthase Produces DNA Mismatches and Results in Excellent Radiosensitization by Flanagan, Sheryl A., PhD, Cooper, Kristin S, Mannava, Sudha, MSc, Nikiforov, Mikhail A., PhD, Shewach, Donna S., PhD

“…Purpose To determine the effect of short hairpin ribonucleic acid (shRNA)-mediated suppression of thymidylate synthase (TS) on cytotoxicity and…”
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Introduction to Cancer Chemotherapeutics by Shewach, Donna S, Kuchta, Robert D

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Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers by Flanagan, Sheryl A, Robinson, Blaine W, Krokosky, Christina M, Shewach, Donna S

“…Radiation sensitization by 2′,2′-difluoro-2′-deoxycytidine (dFdCyd) has correlated with dATP depletion [dFdCDP-mediated inhibition of ribonucleotide reductase…”
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MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches by Flanagan, Sheryl A, Krokosky, Christina M, Mannava, Sudha, Nikiforov, Mikhail A, Shewach, Donna S

“…The antitumor drug 5-fluoro-2'-deoxyuridine (FdUrd) also sensitizes tumor cells to ionizing radiation in vitro and in vivo. Although radiosensitization with…”
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Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence by Mannava, Sudha, Moparthy, Kalyana C, Wheeler, Linda J, Natarajan, Venkatesh, Zucker, Shoshanna N, Fink, Emily E, Im, Michael, Flanagan, Sheryl, Burhans, William C, Zeitouni, Nathalie C, Shewach, Donna S, Mathews, Christopher K, Nikiforov, Mikhail A

“…In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have…”
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N -acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers by Medina, Scott H, Tekumalla, Venkatesh, Chevliakov, Maxim V, Shewach, Donna S, Ensminger, William D, El-Sayed, Mohamed E.H

“…Abstract There is an urgent need for novel polymeric carriers that can selectively deliver a large dose of chemotherapeutic agents into hepatic cancer cells to…”
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Detection of Nucleotide Disbalance in Cells Undergoing Oncogene-Induced Senescence by Nikiforov, Mikhail A, Shewach, Donna S

“…DNA damage response has been characterized as an important mediator of senescence phenotypes induced by activated oncogenes in normal human cells. Depletion of…”
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Late DNA Damage Mediated by Homologous Recombination Repair Results in Radiosensitization with Gemcitabine by Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Knapp, Brendan, Kramer, Aaron, Shewach, Donna S.

“…Gemcitabine (dFdCyd) shows broad antitumor activity in solid tumors in chemotherapeutic regimens or when combined with ionizing radiation (radiosensitization)…”
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Drug Metabolism and Homologous Recombination Repair in Radiosensitization with Gemcitabine by Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Shewach, Donna S.

“…Gemcitabine (difluorodeoxycytidine; dFdCyd) is a potent radiosensitizer, noted for its ability to enhance cytotoxicity with radiation at noncytotoxic…”
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Evidence for Iterative Ratcheting of Receptor-Bound hsp70 between Its ATP and ADP Conformations during Assembly of Glucocorticoid Receptor·hsp90 Heterocomplexes by Morishima, Yoshihiro, Kanelakis, Kimon C, Murphy, Patrick J. M, Shewach, Donna S, Pratt, William B

“…hsp90 and hsp70 are essential components of a five-protein system, including also the nonessential cochaperones Hop, hsp40, and p23, that assembles…”
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Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity by Ladd, Brendon, Ackroyd, Jeffrey J., Hicks, J. Kevin, Canman, Christine E., Flanagan, Sheryl A., Shewach, Donna S.

“…•Homologous recombination deficiency enhances ganciclovir cytotoxicity >14-fold.•Vorinostat inhibits homologous recombination repair…”
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A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy by BOUCHER, Paul D, IM, Michael M, FREYTAG, Svend O, SHEWACH, Donna S

“…The combination of cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-TK) suicide gene protocols has resulted in enhanced antitumor…”
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A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase Is a Suppressor of Melanoma Invasion by Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Bshara, Wiam, Mannava, Sudha, Ackroyd, Jeff, Bagati, Archis, Omilian, Angela R., Im, Michael, Fedtsova, Natalia, Miecznikowski, Jeffrey C., Moparthy, Kalyana C., Zucker, Shoshanna N., Zhu, Qianqian, Kozlova, Nadezhda I., Berman, Albert E., Hoek, Keith S., Gudkov, Andrei V., Shewach, Donna S., Morrison, Carl D., Nikiforov, Mikhail A.

“…Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here,…”
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Targeting Hepatic Cancer Cells with PEGylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands by Medina, Scott H., Tiruchinapally, Gopinath, Chevliakov, Maxim V., Durmaz, Yasemin Yuksel, Stender, Rachell N., Ensminger, William D., Shewach, Donna S., ElSayed, Mohamed E. H.

“…Poly(amidoamine) (PAMAM) dendrimers are branched water‐soluble polymers defined by consecutive generation numbers (Gn) indicating a parallel increase in size,…”
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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion by Mannava, Sudha, Moparthy, Kalyana C, Wheeler, Linda J, Leonova, Katerina I, Wawrzyniak, Joseph A, Bianchi-Smiraglia, Anna, Berman, Albert E, Flanagan, Sheryl, Shewach, Donna S, Zeitouni, Nathalie C, Gudkov, Andrei V, Mathews, Christopher K, Nikiforov, Mikhail A

“…The down-regulation of dominant oncogenes, including C-MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely…”
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Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells by ROBINSON, Blaine W, IM, Michael M, LJUNGMAN, Mats, PRAZ, Francoise, SHEWACH, Donna S

“…Gemcitabine [2',2'-difluoro-2'-deoxycytidine (dFdCyd)] is a potent ionizing radiation sensitizer in solid tumor cells in vitro and in vivo. Previously, we have…”
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