Intra-oral administration of sweet-tasting substances and infants' crying response to immunization: a randomized, placebo-controlled trial

Intra-oral administration of sweet-tasting substances and infants' crying response to immunization: a randomized, placebo-controlled trial

The analgesic effects of four solutions administered intra-orally (25 and 50% sucrose solutions, hydrogenated glucose, and a sterile water placebo) were tested in groups of babies receiving routine DTP (diphtheria, tetanus, and pertussis) and HIB (Haemophilus influenzae type B) injections at the fir...

Full description

Saved in:
Bibliographic Details
Published in:Biology of the neonate Vol. 81; no. 3; p. 163
Main Authors: Ramenghi, Luca A, Webb, A Vivian, Shevlin, Patricia M, Green, Martine, Evans, David J, Levene, Malcolm I
Format: Journal Article
Language:English
Published: Switzerland 01-01-2002
Subjects:
Administration, Oral
Crying
Diphtheria-Tetanus-Pertussis Vaccine - therapeutic use
Glucose - administration & dosage
Glucose - pharmacology
Haemophilus Vaccines - therapeutic use
Humans
Immunization
Infant
Placebos
Solutions
Sucrose - administration & dosage
Sucrose - pharmacology
Time Factors
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The analgesic effects of four solutions administered intra-orally (25 and 50% sucrose solutions, hydrogenated glucose, and a sterile water placebo) were tested in groups of babies receiving routine DTP (diphtheria, tetanus, and pertussis) and HIB (Haemophilus influenzae type B) injections at the first, second, or third immunization. The duration of the baby's cry during 3 min following DTP and HIB injections was measured as main outcome. For all three immunization groups, the babies receiving the placebo generally spent most time crying. For both the DTP and HIB injections, the difference between 50% sucrose and placebo was most evident in the group receiving the 3rd immunization. Intra-oral administration of the 50% sucrose solution, compared to placebo, appeared to reduce the cry response to painful experiences in babies beyond the neonatal period.
ISSN:0006-3126
DOI:10.1159/000051529