Search Results - "Shevde, Lalita A"

The Tumor Microenvironment Innately Modulates Cancer Progression by Hinshaw, Dominique C, Shevde, Lalita A

“…Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment…”
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Role of osteopontin in the pathophysiology of cancer by Shevde, Lalita A., Samant, Rajeev S.

“…Osteopontin (OPN) is a multifunctional cytokine that impacts cell proliferation, survival, drug resistance, invasion, and stem like behavior. Due to its…”
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Merlin regulates signaling events at the nexus of development and cancer by Mota, Mateus, Shevde, Lalita A

“…In this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 (NF2) gene, orchestrates developmental signaling to ensure…”
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ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling by Meng, Erhong, Mitra, Aparna, Tripathi, Kaushlendra, Finan, Michael A, Scalici, Jennifer, McClellan, Steve, Madeira da Silva, Luciana, Reed, Eddie, Shevde, Lalita A, Palle, Komaraiah, Rocconi, Rodney P

“…Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem…”
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An in vitro hyaluronic acid hydrogel based platform to model dormancy in brain metastatic breast cancer cells by Narkhede, Akshay A., Crenshaw, James H., Crossman, David K., Shevde, Lalita A., Rao, Shreyas S.

“…Breast cancer cells (BCCs) can remain dormant at the metastatic site, which when revoked leads to formation of metastasis several years after the treatment of…”
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Nonclassical hedgehog‐gli signaling and its clinical implications by Shevde, Lalita A., Samant, Rajeev S.

“…Hedgehog (Hh) signaling regulates embryonic patterning and organ morphogenesis. It is also involved in regeneration and repair of tissues. Aberrant Hh pathway…”
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Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer by Hanna, Ann, Metge, Brandon J., Bailey, Sarah K., Chen, Dongquan, Chandrashekar, Darshan S., Varambally, Sooryanarayana, Samant, Rajeev S., Shevde, Lalita A.

“…Host responses to tumor cells include tumor suppressing or promoting mechanisms. We sought to detail the effect of Hedgehog (Hh) pathway inhibition on the…”
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Dickkopf1: A tumor suppressor or metastasis promoter? by Menezes, Mitchell E., Devine, Daniel J., Shevde, Lalita A., Samant, Rajeev S.

“…Dickkopf1 (DKK1), a secreted inhibitor of the Wnt/β‐catenin pathway, is a negative regulator of bone formation. DKK1 acts as a switch that transitions prostate…”
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Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer by Mota, Mateus S V, Jackson, William P, Bailey, Sarah K, Vayalil, Praveen, Landar, Aimee, Rostas, Jack W, Mulekar, Madhuri S, Samant, Rajeev S, Shevde, Lalita A

“…Merlin deficiency elicits the co-operative activity of the Hippo and TGF-β pathways to disengage restriction on STAT3 and hexokinase 2, enabling a metabolic…”
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Emerging role of nuclear protein 1 (NUPR1) in cancer biology by Chowdhury, Uttio Roy, Samant, Rajeev S., Fodstad, Oystein, Shevde, Lalita A.

“…NUPR1, or p8 or com1, was first identified from rat pancreas during acute pancreatitis and later as a gene whose expression was upregulated in metastatic…”
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Targeting EMT using low-dose Teniposide by downregulating ZEB2-driven activation of RNA polymerase I in breast cancer by Metge, Brandon J., Alsheikh, Heba Allah M., Kammerud, Sarah C., Chen, Dongquan, Das, Devika, Nebane, N. Miranda, Bostwick, J. Robert, Shevde, Lalita A., Samant, Rajeev S.

“…Metastatic dissemination from the primary tumor is a complex process that requires crosstalk between tumor cells and the surrounding milieu and involves the…”
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The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis by Riker, Adam I, Enkemann, Steven A, Fodstad, Oystein, Liu, Suhu, Ren, Suping, Morris, Christopher, Xi, Yaguang, Howell, Paul, Metge, Brandon, Samant, Rajeev S, Shevde, Lalita A, Li, Wenbin, Eschrich, Steven, Daud, Adil, Ju, Jingfang, Matta, Jaime

“…The process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for…”
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Protocol for generating dormant human brain metastatic breast cancer spheroids in vitro by Kondapaneni, Raghu Vamsi, Gurung, Sumiran Kumar, Shevde, Lalita A., Rao, Shreyas S.

“…Here, we present a protocol to generate dormant brain metastatic breast cancer (BMBC) spheroids utilizing hyaluronic acid (HA) hydrogels. We describe the steps…”
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The Hedgehog Pathway Transcription Factor GLI1 Promotes Malignant Behavior of Cancer Cells by Up-regulating Osteopontin by Das, Shamik, Harris, Lillianne G., Metge, Brandon J., Liu, Suhu, Riker, Adam I., Samant, Rajeev S., Shevde, Lalita A.

“…The role of Hedgehog (Hh) signaling as a developmental pathway is well established. Several recent studies have implicated a role for this pathway in multiple…”
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Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer by Weeks, Shannon E., Kammerud, Sarah C., Metge, Brandon J., AlSheikh, Heba A., Schneider, David A., Chen, Dongquan, Wei, Shi, Mobley, James A., Ojesina, Akinyemi I., Shevde, Lalita A., Samant, Rajeev S.

“…Triple-negative breast cancer (TNBC) patients with upregulated Wnt/β-catenin signaling often have poor clinical prognoses. During pathological examinations of…”
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Merlin deficiency alters the redox management program in breast cancer by Mota, Mateus, Metge, Brandon J., Hinshaw, Dominique C., Alsheikh, Heba A., Chen, Dongquan, Samant, Rajeev S., Shevde, Lalita A.

“…The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues. In order…”
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Genomic regulation of invasion by STAT3 in triple negative breast cancer by McDaniel, Joy M, Varley, Katherine E, Gertz, Jason, Savic, Daniel S, Roberts, Brian S, Bailey, Sarah K, Shevde, Lalita A, Ramaker, Ryne C, Lasseigne, Brittany N, Kirby, Marie K, Newberry, Kimberly M, Partridge, E Christopher, Jones, Angela L, Boone, Braden, Levy, Shawn E, Oliver, Patsy G, Sexton, Katherine C, Grizzle, William E, Forero, Andres, Buchsbaum, Donald J, Cooper, Sara J, Myers, Richard M

“…Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial…”
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Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment by Hanna, Ann, Shevde, Lalita A

“…Cancer poses a serious health problem in society and is increasingly surpassing cardiovascular disease as the leading cause of mortality in the United States…”
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DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity by Menezes, Mitchell E, Mitra, Aparna, Shevde, Lalita A, Samant, Rajeev S

“…DKK1 (dickkopf 1 homologue) is a secreted inhibitor of the Wnt signalling pathway and a critical modulator of tumour promotion and the tumour microenvironment…”
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Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors by Alsheikh, Heba Allah M., Metge, Brandon J., Pruitt, Hawley C., Kammerud, Sarah C., Chen, Dongquan, Wei, Shi, Shevde, Lalita A., Samant, Rajeev S.

“…Molecular dynamics of developmental processes are repurposed by cancer cells to support cancer initiation and progression. Disruption of the delicate balance…”
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