Search Results - "Shevach, Ethan M."

Foxp3 + T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study by Shevach, Ethan M

“…T regulatory (Treg) cells were discovered more than 20 years ago and have remained a topic of intense investigation by immunologists. The initial doubts about…”
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tTregs, pTregs, and iTregs: similarities and differences by Shevach, Ethan M., Thornton, Angela M.

“…Summary Foxp3+ T‐regulatory cells (Tregs) are primarily generated in the thymus (tTreg), but also may be generated extrathymically at peripheral sites (pTreg),…”
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Helios: still behind the clouds by Thornton, Angela M., Shevach, Ethan M.

“…Summary Regulatory T (Treg) cells are a subset of CD4+ T cells that are critical for the maintenance of self‐tolerance. The forkhead box transcription factor…”
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Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires by Thornton, Angela M., Lu, Jinghua, Korty, Patricia E., Kim, Yong Chan, Martens, Craig, Sun, Peter D., Shevach, Ethan M.

“…The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs. We previously proposed that Helios is a marker of thymic derived Treg (tTreg),…”
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GARP (LRRC32) Is Essential for the Surface Expression of Latent TGF-β on Platelets and Activated FOXP3⁺ Regulatory T Cells by Tran, Dat Q., Andersson, John, Wang, Rui, Ramsey, Heather, Unutmaz, Derya, Shevach, Ethan M., Littman, Dan R.

“…TGF-β family members are highly pleiotropic cytokines with diverse regulatory functions. TGF-β is normally found in the latent form associated with…”
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Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment by Gangaplara, Arunakumar, Martens, Craig, Dahlstrom, Eric, Metidji, Amina, Gokhale, Ameya S, Glass, Deborah D, Lopez-Ocasio, Maria, Baur, Rachel, Kanakabandi, Kishore, Porcella, Stephen F, Shevach, Ethan M

“…Regulatory T cells (Tregs) play a cardinal role in the immune system by suppressing detrimental autoimmune responses, but their role in acute, chronic…”
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The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? by Shevach, Ethan M, Stephens, Geoffrey L

“…Stimulation of T cells through GITR (glucocorticoid-induced tumour-necrosis-factor-receptor-related protein) has been shown to enhance immunity to tumours and…”
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Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway by Elias, Kevin M., Laurence, Arian, Davidson, Todd S., Stephens, Geoffrey, Kanno, Yuka, Shevach, Ethan M., O'Shea, John J.

“…CD4+ helper T (Th) cells play a crucial role in the delicate balance between host defense and autoimmune disease. Two important populations of helper T cells…”
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Nonredundant roles for Stat5a/b in directly regulating Foxp3 by Yao, Zhengju, Kanno, Yuka, Kerenyi, Marc, Stephens, Geoffrey, Durant, Lydia, Watford, Wendy T., Laurence, Arian, Robinson, Gertraud W., Shevach, Ethan M., Moriggl, Richard, Hennighausen, Lothar, Wu, Changyou, O'Shea, John J.

“…Stats (signal transducers and activators of transcription) regulate multiple aspects of T-cell fate. T regulatory (Treg) cells are a critical subset that…”
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Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells by Yang, Yujian H., Istomine, Roman, Alvarez, Fernando, Al-Aubodah, Tho-Alfakar, Shi, Xiang Qun, Takano, Tomoko, Thornton, Angela M., Shevach, Ethan M., Zhang, Ji, Piccirillo, Ciriaco A.

“…Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a…”
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CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus by Nath, Pulak Ranjan, Gangaplara, Arunakumar, Pal-Nath, Dipasmita, Mandal, Ajeet, Maric, Dragan, Sipes, John M, Cam, Maggie, Shevach, Ethan M, Roberts, David D

“…CD47 is a ubiquitous cell surface receptor that directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1 and limits…”
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Mechanisms of Foxp3 + T Regulatory Cell-Mediated Suppression by Shevach, Ethan M.

“…Foxp3 + T regulatory (Treg) cells control all aspects of the immune response. Here, I will review the in vitro model systems that have been developed to define…”
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T Follicular Regulatory Cell Suppression of T Follicular Helper Cell Function Is Context-Dependent in vitro by Lopez-Ocasio, Maria, Buszko, Maja, Blain, Melissa, Wang, Ke, Shevach, Ethan M

“…The production of antibody-secreting plasma cells and memory B cells requires the interaction of T follicular helper (Tfh) cells with B cells in the follicle…”
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Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells by Cova, Giovanni, Taroni, Chiara, Deau, Marie-Céline, Cai, Qi, Mittelheisser, Vincent, Philipps, Muriel, Jung, Matthieu, Cerciat, Marie, Le Gras, Stéphanie, Thibault-Carpentier, Christelle, Jost, Bernard, Carlsson, Leif, Thornton, Angela M, Shevach, Ethan M, Kirstetter, Peggy, Kastner, Philippe, Chan, Susan

“…Our understanding of cell fate decisions in hematopoietic stem cells is incomplete. Here, we show that the transcription factor Helios is highly expressed in…”
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Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease by Morina, Lyra, Jones, Madalyn E, Oguz, Cihan, Kaplan, Mariana J, Gangaplara, Arunakumar, Fitzhugh, Courtney D, Kanakry, Christopher G, Shevach, Ethan M, Buszko, Maja

“…Foxp3 is regarded as the major transcription factor for T regulatory (T ) cells and expression of Foxp3 is used to identify and quantitate Treg cells in mouse…”
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A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry by Akkaya, Billur, Miozzo, Pietro, Holstein, Amanda H, Shevach, Ethan M, Pierce, Susan K, Akkaya, Munir

“…Barcoding of biological samples is a commonly used strategy to mark or identify individuals within a complex mixture. However, cell barcoding has not yet found…”
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The GARP/Latent TGF‐β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance by Edwards, Justin P., Hand, Timothy W., Morais da Fonseca, Denise, Glass, Deborah D., Belkaid, Yasmine, Shevach, Ethan M.

“…Treg cells can secrete latent TGF‐β1 (LTGF‐β1), but can also utilize an alternative pathway for transport and expression of LTGF‐β1 on the cell surface in…”
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The role of platelet and endothelial GARP in thrombosis and hemostasis by Vermeersch, Elien, Denorme, Frederik, Maes, Wim, De Meyer, Simon F, Vanhoorelbeke, Karen, Edwards, Justin, Shevach, Ethan M, Unutmaz, Derya, Fujii, Hodaka, Deckmyn, Hans, Tersteeg, Claudia

“…Glycoprotein-A Repetitions Predominant protein (GARP or LRRC32) is present on among others human platelets and endothelial cells. Evidence for its involvement…”
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IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms by Shao, Ying, Yang, William Y, Saaoud, Fatma, Drummer, 4th, Charles, Sun, Yu, Xu, Keman, Lu, Yifan, Shan, Huimin, Shevach, Ethan M, Jiang, Xiaohua, Wang, Hong, Yang, Xiaofeng

“…Tregs play vital roles in suppressing atherogenesis. Pathological conditions reshape Tregs and increase Treg-weakening plasticity. It remains unclear how Tregs…”
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Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens by Punkosdy, George A, Blain, Melissa, Glass, Deborah D, Lozano, Mary M, O'Mara, Leigh, Dudley, Jaquelin P, Ahmed, Rafi, Shevach, Ethan M

“…Regulatory T cells (Treg) play critical roles in the modulation of immune responses to infectious agents. Further understanding of the factors that control…”
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