Search Results - "Shetye, Snehal S."

Collagen V haploinsufficiency in female murine patellar tendons results in altered matrix engagement and cellular density, demonstrating decreased healing by Carlson, Jaclyn A., Shetye, Snehal S., Sun, Mei, Weiss, Stephanie N., Birk, David E., Soslowsky, Louis J.

“…Collagen V (Col5) is a quantitatively minor component of collagen fibrils comprising tendon, however, plays a crucial role in regulation of development and…”
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Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons by Robinson, Kelsey A., Sun, Mei, Barnum, Carrie E., Weiss, Stephanie N., Huegel, Julianne, Shetye, Snehal S., Lin, Linda, Saez, Daniel, Adams, Sheila M., Iozzo, Renato V., Soslowsky, Louis J., Birk, David E.

“…The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of collagen fibril and matrix assembly. The goal of this work was to…”
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Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon by Sun, Mei, Luo, Eric Y., Adams, Sheila M., Adams, Thomas, Ye, Yaping, Shetye, Snehal S., Soslowsky, Louis J., Birk, David E.

“…•Conditional Col11a1 mouse models were created and characterized.•Col11a1 mouse models were used to define the regulatory roles of collagen XI in establishing…”
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Colonization of the cervicovaginal space with Gardnerella vaginalis leads to local inflammation and cervical remodeling in pregnant mice by Sierra, Luz-Jeannette, Brown, Amy G, Barilá, Guillermo O, Anton, Lauren, Barnum, Carrie E, Shetye, Snehal S, Soslowsky, Louis J, Elovitz, Michal A

“…The role of the cervicovaginal (CV) microbiome in regulating cervical function during pregnancy is poorly understood. Gardnerella vaginalis (G. vaginalis) is…”
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Pedicle screw placement in the lumbar spine: effect of trajectory and screw design on acute biomechanical purchase by Wray, Steven, Mimran, Ronnie, Vadapalli, Sasidhar, Shetye, Snehal S, McGilvray, Kirk C, Puttlitz, Christian M

“…OBJECT Low bone mineral density in patients undergoing lumbar spinal surgery with screws is an especially difficult challenge because poor bone quality can…”
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Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation by Park, Na Rae, Shetye, Snehal S., Bogush, Igor, Keene, Douglas R., Tufa, Sara, Hudson, David M., Archer, Marilyn, Qin, Ling, Soslowsky, Louis J., Dyment, Nathaniel A., Joeng, Kyu Sang

“…Tendon plays a critical role in the joint movement by transmitting force from muscle to bone. This transmission of force is facilitated by its specialized…”
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MRI-derived bone porosity index correlates to bone composition and mechanical stiffness by Hong, Abigail L., Ispiryan, Mikayel, Padalkar, Mugdha V., Jones, Brandon C., Batzdorf, Alexandra S., Shetye, Snehal S., Pleshko, Nancy, Rajapakse, Chamith S.

“…The MRI-derived porosity index (PI) is a non-invasively obtained biomarker based on an ultrashort echo time sequence that images both bound and pore water…”
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Dose-dependent effects of enzyme replacement therapy on skeletal disease progression in mucopolysaccharidosis VII dogs by Gawri, Rahul, Lau, Yian Khai, Lin, Gloria, Shetye, Snehal S., Zhang, Chenghao, Jiang, Zhirui, Abdoun, Khaled, Scanzello, Carla R., Jo, Stephanie Y., Mai, Wilfried, Dodge, George R., Casal, Margret L., Smith, Lachlan J.

“…Mucopolysaccharidosis (MPS) VII is an inherited lysosomal storage disorder characterized by deficient activity of the enzyme β-glucuronidase. Skeletal…”
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Biaxial response of ovine spinal cord dura mater by Shetye, Snehal S., Deault, Matthew M., Puttlitz, Christian M.

“…The dura mater performs a major functional role in the stability and mechanical response of the spinal cord complex. Computational techniques investigating the…”
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Evaluation of Autologous Protein Solution Injection for Treatment of Superficial Digital Flexor Tendonitis in an Equine Model by Gaesser, Angela M, Underwood, Claire, Linardi, Renata L, Even, Kayla M, Reef, Virginia B, Shetye, Snehal S, Mauck, Robert L, King, William J, Engiles, Julie B, Ortved, Kyla F

“…Autologous protein solution (APS) has been used anecdotally for intralesional treatment of tendon and ligament injuries, however, its use in these injuries has…”
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Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function by Leiphart, Ryan J., Pham, Hai, Harvey, Tyler, Komori, Taishi, Kilts, Tina M., Shetye, Snehal S., Weiss, Stephanie N., Adams, Sheila M., Birk, David E., Soslowsky, Louis J., Young, Marian F.

“…•Biglycan and collagen VI co-localize within nascent tendon matrix indicating possible synergy in tissue function.•Biglycan deficiency reduced tendon fibril…”
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Fracture Limits of Maxillary Fourth Premolar Teeth in Domestic Dogs Under Applied Forces by Soltero-Rivera, Maria, Elliott, Matthew I, Hast, Michael W, Shetye, Snehal S, Castejon-Gonzalez, Ana C, Villamizar-Martinez, Lenin A, Stefanovski, Darko, Reiter, Alexander M

“…A cadaveric study was performed to investigate the external mechanical forces required to fracture maxillary fourth premolar teeth in domestic dogs and…”
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MRI-derived porosity index is associated with whole-bone stiffness and mineral density in human cadaveric femora by Jones, Brandon C., Jia, Shaowei, Lee, Hyunyeol, Feng, Anna, Shetye, Snehal S., Batzdorf, Alexandra, Shapira, Nadav, Noël, Peter B., Pleshko, Nancy, Rajapakse, Chamith S.

“…Ultrashort echo time (UTE) magnetic resonance imaging (MRI) measures proton signals in cortical bone from two distinct water pools, bound water, or water that…”
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Long-Term Effects of Reproduction and Lactation on the Rat Supraspinatus Tendon and Proximal Humerus by Fung, Ashley K, Li, Yihan, Wang, Jasmine, Leahy, Thomas P, Shetye, Snehal S, Liu, X Sherry, Soslowsky, Louis J

“…During pregnancy and breastfeeding, women undergo hormonal fluctuations required for fetal development, parturition, and infant growth. These changes have…”
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Short- and Long-Term Exercise Results in a Differential Achilles Tendon Mechanical Response by Chen, Mengcun, Shetye, Snehal S, Rooney, Sarah Ilkhanipour, Soslowsky, Louis J

“…The study was conducted to define the biomechanical response of rat Achilles tendon after a single bout of exercise and a short or long duration of daily…”
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Achilles Tendon Ruptures in Middle-Aged Rats Heal Poorly Compared With Those in Young and Old Rats by Leahy, Thomas P., Nuss, Courtney A., Evans, Mary Kate, Fung, Ashley K., Shetye, Snehal S., Soslowsky, Louis J.

“…Background: Achilles tendon ruptures are painful and debilitating injuries and are most common in middle-aged patients. There is a lack of understanding of the…”
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MRI-based assessment of proximal femur strength compared to mechanical testing by Rajapakse, Chamith S., Farid, Alexander R., Kargilis, Daniel C., Jones, Brandon C., Lee, Jae S., Johncola, Alyssa J., Batzdorf, Alexandra S., Shetye, Snehal S., Hast, Michael W., Chang, Gregory

“…Half of the women who sustain a hip fracture would not qualify for osteoporosis treatment based on current DXA-estimated bone mineral density criteria…”
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Inhibition of glucose use improves structural recovery of injured Achilles tendon in mice by Izumi, Soutarou, Oichi, Takeshi, Shetye, Snehal S., Zhang, Kairui, Wilson, Kimberly, Iwamoto, Masahiro, Kuo, Catherine K., Akabudike, Ngozi, Adachi, Nobuo, Soslowsky, Louis J., Enomoto‐Iwamoto, Motomi

“…Injured tendons do not regain their native structure except at fetal or very young ages. Healing tendons often show mucoid degeneration involving accumulation…”
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Biglycan has a major role in maintenance of mature tendon mechanics by Beach, Zakary M., Bonilla, Kelsey A., Dekhne, Mihir S., Sun, Mei, Adams, Thomas H., Adams, Sheila M., Weiss, Stephanie N., Rodriguez, Ashley B., Shetye, Snehal S., Birk, David E., Soslowsky, Louis J.

“…Decorin and biglycan are two small leucine‐rich proteoglycans (SLRPs) that regulate collagen fibrillogenesis and extracellular matrix assembly in tendon. The…”
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Pregnancy and Lactation Impair Subchondral Bone Leading to Reduced Rat Supraspinatus Tendon-to-Bone Insertion Site Failure Properties by Fung, Ashley K, Shetye, Snehal S, Li, Yihan, Zhou, Yilu, Sherry Liu, X, Soslowsky, Louis J

“…Pregnant women experience weight gain, gait changes, and biochemical fluctuations that impair joint function and alter the maternal skeleton. Hormonal changes…”
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