Search Results - "Shetty, Amol C."

Brain feminization requires active repression of masculinization via DNA methylation by Nugent, Bridget M, Wright, Christopher L, Shetty, Amol C, Hodes, Georgia E, Lenz, Kathryn M, Mahurkar, Anup, Russo, Scott J, Devine, Scott E, McCarthy, Margaret M

“…Hormone-induced brain masculinization occurs during a perinatal sensitive period but endures into adulthood. Researchers explored DNA methylation as a…”
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Best practices on the differential expression analysis of multi-species RNA-seq by Chung, Matthew, Bruno, Vincent M, Rasko, David A, Cuomo, Christina A, Muñoz, José F, Livny, Jonathan, Shetty, Amol C, Mahurkar, Anup, Dunning Hotopp, Julie C

“…Advances in transcriptome sequencing allow for simultaneous interrogation of differentially expressed genes from multiple species originating from a single RNA…”
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Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire by Harris, Daniel N., Song, Wei, Shetty, Amol C., Levano, Kelly S., Cáceres, Omar, Padilla, Carlos, Borda, Víctor, Tarazona, David, Trujillo, Omar, Sanchez, Cesar, Kessler, Michael D., Galarza, Marco, Capristano, Silvia, Montejo, Harrison, Flores-Villanueva, Pedro O., Tarazona-Santos, Eduardo, O’Connor, Timothy D., Guio, Heinner

“…Native Americans from the Amazon, Andes, and coastal geographic regions of South America have a rich cultural heritage but are genetically understudied,…”
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Whole blood transcriptomic profiles can differentiate vulnerability to chronic low back pain by Dorsey, Susan G, Renn, Cynthia L, Griffioen, Mari, Lassiter, Cameron B, Zhu, Shijun, Huot-Creasy, Heather, McCracken, Carrie, Mahurkar, Anup, Shetty, Amol C, Jackson-Cook, Colleen K, Kim, Hyungsuk, Henderson, Wendy A, Saligan, Leorey, Gill, Jessica, Colloca, Luana, Lyon, Debra E, Starkweather, Angela R

“…The mechanisms underlying the transition from acute to chronic pain remain unclear. Here, we sought to characterize the transcriptome associated with chronic…”
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Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis by Kavaliauskas, Povilas, Gu, Yiyou, Hasin, Naushaba, Graf, Karen T., Alqarihi, Abdullah, Shetty, Amol C., McCracken, Carrie, Walsh, Thomas J., Ibrahim, Ashraf S., Bruno, Vincent M.

“…During pulmonary mucormycosis, inhaled sporangiospores adhere to, germinate, and invade airway epithelial cells to establish infection. We provide evidence…”
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Therapeutic implications of C. albicans-S. aureus mixed biofilm in a murine subcutaneous catheter model of polymicrobial infection by Vila, Taissa, Kong, Eric F., Montelongo-Jauregui, Daniel, Van Dijck, Patrick, Shetty, Amol C., McCracken, Carrie, Bruno, Vincent M., Jabra-Rizk, Mary Ann

“…Biofilm-associated polymicrobial infections tend to be challenging to treat. Candida albicans and Staphylococcus aureus are leading pathogens due to their…”
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Comparative transcriptomics from intestinal cells of permissive and non-permissive hosts during Ancylostoma ceylanicum infection reveals unique signatures of protection and host specificity by Langeland, Andrea, Grill, Emilia, Shetty, Amol C., O'Halloran, Damien M., Hawdon, John M.

“…Soil-transmitted nematodes (STNs) place a tremendous burden on health and economics worldwide with an estimate of at least 1.5 billion people, or 24% of the…”
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An integrated genomic and transcriptomic survey of mucormycosis-causing fungi by Chibucos, Marcus C., Soliman, Sameh, Gebremariam, Teclegiorgis, Lee, Hongkyu, Daugherty, Sean, Orvis, Joshua, Shetty, Amol C., Crabtree, Jonathan, Hazen, Tracy H., Etienne, Kizee A., Kumari, Priti, O’Connor, Timothy D., Rasko, David A., Filler, Scott G., Fraser, Claire M., Lockhart, Shawn R., Skory, Christopher D., Ibrahim, Ashraf S., Bruno, Vincent M.

“…Mucormycosis is a life-threatening infection caused by Mucorales fungi. Here we sequence 30 fungal genomes, and perform transcriptomics with three…”
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Author Correction: An optimized protocol for single nuclei isolation from clinical biopsies for RNA‑seq by Rousselle, Thomas V., McDaniels, Jennifer M., Shetty, Amol C., Bardhi, Elissa, Maluf, Daniel G., Mas, Valeria R.

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Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome by Bruno, Vincent M, Shetty, Amol C, Yano, Junko, Fidel, Jr, Paul L, Noverr, Mairi C, Peters, Brian M

“…Treatment of vulvovaginal candidiasis (VVC), caused most frequently by Candida albicans, represents a significant unmet clinical need. C. albicans, as both a…”
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An optimized protocol for single nuclei isolation from clinical biopsies for RNA-seq by Rousselle, Thomas V., McDaniels, Jennifer M., Shetty, Amol C., Bardhi, Elissa, Maluf, Daniel G., Mas, Valeria R.

“…Single nuclei RNA sequencing (snRNA-seq) has evolved as a powerful tool to study complex human diseases. Single cell resolution enables the study of novel cell…”
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Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing by Shenoy, Anukul T, Brissac, Terry, Gilley, Ryan P, Kumar, Nikhil, Wang, Yong, Gonzalez-Juarbe, Norberto, Hinkle, Whitney S, Daugherty, Sean C, Shetty, Amol C, Ott, Sandra, Tallon, Luke J, Deshane, Jessy, Tettelin, Hervé, Orihuela, Carlos J

“…For over 130 years, invasive pneumococcal disease has been associated with the presence of extracellular planktonic pneumococci, i.e. diplococci or short…”
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Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli by Hazen, Tracy H., Michalski, Jane, Luo, Qingwei, Shetty, Amol C., Daugherty, Sean C., Fleckenstein, James M., Rasko, David A.

“…Escherichia coli that are capable of causing human disease are often classified into pathogenic variants (pathovars) based on their virulence gene content…”
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Dual species transcriptomics reveals conserved metabolic and immunologic processes in interactions between human neutrophils and Neisseria gonorrhoeae by Potter, Aimee D, Edwards, Vonetta L, D'Mello, Adonis, Gray, Mary C, Shetty, Amol C, Forehand, Amy L, Westlake, Camille S, Lamb, Evan R, Zhao, Xuechu, Ragland, Stephanie A, Criss, Alison K, Tettelin, Hervé

“…Neisseria gonorrhoeae (the gonococcus, Gc) causes the sexually transmitted infection gonorrhea. Gc is a prominent threat to human health by causing severe…”
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Microdeletions of 3q29 Confer High Risk for Schizophrenia by Mulle, Jennifer Gladys, Dodd, Anne F., McGrath, John A., Wolyniec, Paula S., Mitchell, Adele A., Shetty, Amol C., Sobreira, Nara L., Valle, David, Rudd, M. Katharine, Satten, Glen, Cutler, David J., Pulver, Ann E., Warren, Stephen T.

“…Schizophrenia (SZ) is a severe psychiatric illness that affects ∼1% of the population and has a strong genetic underpinning. Recently, genome-wide analysis of…”
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New signaling pathways govern the host response to C. albicans infection in various niches by Liu, Yaoping, Shetty, Amol C, Schwartz, Jennifer A, Bradford, L Latey, Xu, Wenjie, Phan, Qyunh T, Kumari, Priti, Mahurkar, Anup, Mitchell, Aaron P, Ravel, Jacques, Fraser, Claire M, Filler, Scott G, Bruno, Vincent M

“…Candida albicans, the major invasive fungal pathogen of humans, can cause both debilitating mucosal infections and fatal invasive infections. Understanding the…”
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Simultaneous transcriptional profiling of bacteria and their host cells by Humphrys, Michael S, Creasy, Todd, Sun, Yezhou, Shetty, Amol C, Chibucos, Marcus C, Drabek, Elliott F, Fraser, Claire M, Farooq, Umar, Sengamalay, Naomi, Ott, Sandy, Shou, Huizhong, Bavoil, Patrik M, Mahurkar, Anup, Myers, Garry S A

“…We developed an RNA-Seq-based method to simultaneously capture prokaryotic and eukaryotic expression profiles of cells infected with intracellular bacteria. As…”
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A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1 by Rybak, Jeffrey M., Xie, Jinhong, Martin-Vicente, Adela, Guruceaga, Xabier, Thorn, Harrison I., Nywening, Ashley V., Ge, Wenbo, Souza, Ana C. O., Shetty, Amol C., McCracken, Carrie, Bruno, Vincent M., Parker, Josie E., Kelly, Steven L., Snell, Hannah M., Cuomo, Christina A., Rogers, P. David, Fortwendel, Jarrod R.

“…Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis…”
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MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL by Landon, Ari L., Muniandy, Parameswary A., Shetty, Amol C., Lehrmann, Elin, Volpon, Laurent, Houng, Simone, Zhang, Yongqing, Dai, Bojie, Peroutka, Raymond, Mazan-Mamczarz, Krystyna, Steinhardt, James, Mahurkar, Anup, Becker, Kevin G., Borden, Katherine L., Gartenhaus, Ronald B.

“…The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development…”
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Determining Aspergillus fumigatus transcription factor expression and function during invasion of the mammalian lung by Liu, Hong, Xu, Wenjie, Bruno, Vincent M, Phan, Quynh T, Solis, Norma V, Woolford, Carol A, Ehrlich, Rachel L, Shetty, Amol C, McCraken, Carrie, Lin, Jianfeng, Bromley, Michael J, Mitchell, Aaron P, Filler, Scott G

“…To gain a better understanding of the transcriptional response of Aspergillus fumigatus during invasive pulmonary infection, we used a NanoString nCounter to…”
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