Search Results - "Sheth, Payal"

Selective small-molecule inhibition of an RNA structural element by Howe, John A., Wang, Hao, Fischmann, Thierry O., Balibar, Carl J., Xiao, Li, Galgoci, Andrew M., Malinverni, Juliana C., Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M., Mann, Paul A., Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E., Walker, Scott S., Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A., Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G., Zhang, Rumin, Sheth, Payal R., Gill, Charles J., Tang, Haifeng, Roemer, Terry

“…Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene…”
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Structural basis for selectivity and diversity in angiotensin II receptors by Zhang, Haitao, Han, Gye Won, Batyuk, Alexander, Ishchenko, Andrii, White, Kate L., Patel, Nilkanth, Sadybekov, Anastasiia, Zamlynny, Beata, Rudd, Michael T., Hollenstein, Kaspar, Tolstikova, Alexandra, White, Thomas A., Hunter, Mark S., Weierstall, Uwe, Liu, Wei, Babaoglu, Kerim, Moore, Eric L., Katz, Ryan D., Shipman, Jennifer M., Garcia-Calvo, Margarita, Sharma, Sujata, Sheth, Payal, Soisson, Stephen M., Stevens, Raymond C., Katritch, Vsevolod, Cherezov, Vadim

“…The angiotensin II receptors AT 1 R and AT 2 R serve as key components of the renin–angiotensin–aldosterone system. AT 1 R has a central role in the regulation…”
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Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography by Orth, Peter, Xiao, Li, Hernandez, Lorraine D., Reichert, Paul, Sheth, Payal R., Beaumont, Maribel, Yang, Xiaoyu, Murgolo, Nicholas, Ermakov, Grigori, DiNunzio, Edward, Racine, Fred, Karczewski, Jerzy, Secore, Susan, Ingram, Richard N., Mayhood, Todd, Strickland, Corey, Therien, Alex G.

“…The symptoms of Clostridium difficile infections are caused by two exotoxins, TcdA and TcdB, which target host colonocytes by binding to unknown cell surface…”
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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 by Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M

“…Crystal structures of hGPR40, a target for treatment of type 2 diabetes, bound to a partial and an allosteric agonist explain the binding cooperativity between…”
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Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2 by Wen, Xiujuan, Liu, Chang, Ghislain, Lucien, Tovar, Kiersten, Shah, Vinit, Stout, Steven J, Cifelli, Steven, Satapati, Santhosh, O’Donnell, Gregory, Sheth, Payal R, Wildey, Mary Jo, Datwani, Sammy S, Covey, Thomas R, Bateman, Kevin P, McLaren, David G

“…The primary goal of high-throughput screening (HTS) is to rapidly survey a broad collection of compounds, numbering from tens of thousands to millions of…”
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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets by Mann, Paul A, Müller, Anna, Wolff, Kerstin A, Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E, Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R, Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J, Pinho, Mariana G, Schneider, Tanja, Roemer, Terry

“…Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we…”
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Structural basis of CX-4945 binding to human protein kinase CK2 by Ferguson, Andrew D., Sheth, Payal R., Basso, Andrea D., Paliwal, Sunil, Gray, Kimberly, Fischmann, Thierry O., Le, Hung V.

“…Protein kinase CK2 (CK2), a constitutively active serine/threonine kinase, is involved in a variety of roles essential to the maintenance of cellular…”
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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci by Lee, Sang Ho, Wang, Hao, Labroli, Marc, Koseoglu, Sandra, Zuck, Paul, Mayhood, Todd, Gill, Charles, Mann, Paul, Sher, Xinwei, Ha, Sookhee, Yang, Shu-Wei, Mandal, Mihir, Yang, Christine, Liang, Lianzhu, Tan, Zheng, Tawa, Paul, Hou, Yan, Kuvelkar, Reshma, DeVito, Kristine, Wen, Xiujuan, Xiao, Jing, Batchlett, Michelle, Balibar, Carl J, Liu, Jenny, Xiao, Jianying, Murgolo, Nicholas, Garlisi, Charles G, Sheth, Payal R, Flattery, Amy, Su, Jing, Tan, Christopher, Roemer, Terry

“…The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current β-lactam antibiotics and created…”
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Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab by Hernandez, Lorraine D., Kroh, Heather K., Hsieh, Edward, Yang, Xiaoyu, Beaumont, Maribel, Sheth, Payal R., DiNunzio, Edward, Rutherford, Stacey A., Ohi, Melanie D., Ermakov, Grigori, Xiao, Li, Secore, Susan, Karczewski, Jerzy, Racine, Fred, Mayhood, Todd, Fischer, Paul, Sher, Xinwei, Gupta, Pulkit, Lacy, D. Borden, Therien, Alex G.

“…The exotoxins toxin A (TcdA) and toxin B (TcdB) are produced by the bacterial pathogen Clostridium difficile and are responsible for the pathology associated…”
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Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling by Hernandez, Lorraine D, Racine, Fred, Xiao, Li, DiNunzio, Edward, Hairston, Nichelle, Sheth, Payal R, Murgolo, Nicholas J, Therien, Alex G

“…Clostridium difficile infections (CDIs) are the leading cause of hospital-acquired infectious diarrhea and primarily involve two exotoxins, TcdA and TcdB…”
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Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics by Downes, Daniel P, Zhong, Wendy, Zhang, Ji, Chen, Bingming, Satapati, Santhosh, Metzger, Daniel, Godinez, Guillermo, Lao, Julie, Sheth, Payal R, McLaren, David G, Talukdar, Saswata, Previs, Stephen F

“…Spatial characterization of triglyceride metabolism is an area of significant interest which can be enabled by mass spectrometry imaging via recent advances in…”
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Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats by Sheth, Payal A., Pawar, Anil T., Mote, Chandrashekhar S., More, Chandrakant

“…Over two billion people around the world suffer from anemia. Majority of populations are using dietary supplements and herbal medicines for the management of…”
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Examining Targeted Protein Degradation from Physiological and Analytical Perspectives: Enabling Translation between Cells and Subjects by Daurio, Natalie A., Zhou, Haihong, Chen, Ying, Sheth, Payal R., Imbriglio, Jason E., McLaren, David G., Tawa, Paul, Rachdaoui, Nadia, Previs, Michael J., Kasumov, Takhar, O’Neil, Jennifer, Previs, Stephen F.

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Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS by Berejnaia, Olga, Wang, Hao, Labroli, Marc, Yang, Christine, Gill, Charles, Xiao, Jianying, Hesk, David, DeJesus, Reynalda, Su, Jing, Tan, Christopher M., Sheth, Payal R., Kavana, Michael, McLaren, David G.

“…The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created an urgent need for new therapeutic agents capable of combating this threat. We…”
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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus by Yang, Shu-Wei, Pan, Jianping, Yang, Christine, Labroli, Marc, Pan, Weidong, Caldwell, John, Ha, Sookhee, Koseoglu, Sandra, Xiao, Jing C., Mayhood, Todd, Sheth, Payal R., Garlisi, Charles G., Wu, Jin, Lee, Sang Ho, Wang, Hao, Tan, Christopher M., Roemer, Terry, Su, Jing

“…A series of benzimidazole analogs have been synthesized and displayed potent WTA inhibitory activity and antibacterial activity in combination with imipenem…”
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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase by Walker, Scott S, Labroli, Marc, Painter, Ronald E, Wiltsie, Judyann, Sherborne, Brad, Murgolo, Nicholas, Sher, Xinwei, Mann, Paul, Zuck, Paul, Garlisi, Charles G, Su, Jing, Kargman, Stacia, Xiao, Li, Scapin, Giovanna, Salowe, Scott, Devito, Kristine, Sheth, Payal, Buist, Nichole, Tan, Christopher M, Black, Todd A, Roemer, Terry

“…To combat the threat of antibiotic-resistant Gram-negative bacteria, novel agents that circumvent established resistance mechanisms are urgently needed. Our…”
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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies by Satapati, Santhosh, Downes, Daniel P., Metzger, Daniel, Shankaran, Harish, Talukdar, Saswata, Zhou, Yingjiang, Ren, Zhao, Chen, Michelle, Lim, Yeon-Hee, Hatcher, Nathan G., Wen, Xiujuan, Sheth, Payal R., McLaren, David G., Previs, Stephen F.

“…Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence…”
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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain by Sheth, Payal R, Shipps, Gerald W, Seghezzi, Wolfgang, Smith, Catherine K, Chuang, Cheng-Chi, Sanden, David, Basso, Andrea D, Vilenchik, Lev, Gray, Kimberly, Annis, D. Allen, Nickbarg, Elliott, Ma, Yao, Lahue, Brian, Herbst, Ronald, Le, Hung V

“…Affinity selection−mass spectrometry (AS-MS) screening of kinesin spindle protein (KSP) followed by enzyme inhibition studies and temperature-dependent…”
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Fully Activated MEK1 Exhibits Compromised Affinity for Binding of Allosteric Inhibitors U0126 and PD0325901 by Sheth, Payal R, Liu, Yuqi, Hesson, Thomas, Zhao, Jia, Vilenchik, Lev, Liu, Yan-Hui, Mayhood, Todd W, Le, Hung V

“…Kinases catalyze the transfer of γ-phosphate from ATP to substrate protein residues triggering signaling pathways responsible for a plethora of cellular…”
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Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of 2H-Labeling of Small Molecules by Downes, Daniel P., Kasumov, Takhar, Daurio, Natalie A., Wood, Neil B., Previs, Michael J., Sheth, Payal R., McLaren, David G., Previs, Stephen F.

“…Stable isotope tracers can be used to quantify the activity of metabolic pathways. Specifically, 2H-water is quite versatile, and its incorporation into…”
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