Search Results - "Shet, M S"

Metabolism of the Antiandrogenic Drug (Flutamide) by Human CYP1A2 by SHET, M. S, MCPHAUL, M, FISHER, C. W, STALLINGS, N. R, ESTABROOK, R. W

“…The antiandrogenic drug, flutamide, is widely used in the treatment of carcinoma of the prostate. The present study examines the metabolism of flutamide by…”
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High-Level Expression in Escherichia coli of Enzymatically Active Fusion Proteins Containing the Domains of Mammalian Cytochromes P450 and NADPH- P450 Reductase Flavoprotein by Fisher, Charles W., Shet, Manjunath S., Caudle, Deborah L., Martin-Wixtrom, Cheryl A., Estabrook, Ronald W.

“…This report describes the properties of two mammalian cytochromes P450 that have been expressed at high levels in Escherichia coli as enzymatically active…”
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In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices by Rodrigues, A D, Mulford, D J, Lee, R D, Surber, B W, Kukulka, M J, Ferrero, J L, Thomas, S B, Shet, M S, Estabrook, R W

“…The metabolism of terfenadine was studied with a cDNA-expressed/purified recombinant fusion protein containing human liver microsomal cytochrome P4503A4…”
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Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193 by Machinist, J M, Mayer, M D, Shet, M S, Ferrero, J L, Rodrigues, A D

“…In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]zileuton (ABT-077) and its…”
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Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1 by Faulkner, K M, Shet, M S, Fisher, C W, Estabrook, R W

“…The cyclic enzymatic function of a cytochrome P450, as it catalyzes the oxygen-dependent metabolism of many organic chemicals, requires the delivery of two…”
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Human Cytochrome P450 3A4: Enzymatic Properties of a Purified Recombinant Fusion Protein Containing NADPH-P450 Reductase by Shet, Manjunath S., Fisher, Charles W., Holmans, Priscilla L., Estabrook, Ronald W.

“…Human cytochrome P450 3A4 is recognized as the catalyst for the oxygen-dependent metabolism of a diverse group of medically important chemicals, including the…”
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Purification, characterization, and cDNA cloning of an NADPH-cytochrome P450 reductase from mung bean by Shet, M.S. (The University of Texas Southwestern Medical Center, Dallas, TX), Sathasivan, K, Arlotto, M.A, Mehdy, M.C, Estabrook, R.W

“…We report here the isolation and deduced amino acid sequence of the flavoprotein, NADPH-cytochrome P450 (cytochrome c) reductase (EC 1.6.2.4), associated with…”
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The high-level expression in Escherichia coli of the membrane-bound form of human and rat cytochrome b5 and studies on their mechanism of function by Holmans, P L, Shet, M S, Martin-Wixtrom, C A, Fisher, C W, Estabrook, R W

“…A T7 expression system is described for the high-level production in Escherichia coli of the membrane-bound form of human and rat cytochrome b5. The cDNAs of…”
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Chemical modification studies on a lectin from winged-bean [Psophocarpus tetragonolobus (L.) DC] tubers by Shet, M.S, Madaiah, M

“…The effect of chemical modification on a D(+)-galactose-specific lectin isolated from winged-bean tubers was investigated to identify the type of amino acid…”
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Application of electrochemistry for P450-catalyzed reactions by Estabrook, R W, Faulkner, K M, Shet, M S, Fisher, C W

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A lectin from winged bean (Psophocarpus tetragonolobus) tubers by Shet, M S, Murugiswamy, B, Madaiah, M

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A lectin from the thigh muscle of Rana tigerina by Shet, M S, Madaiah, M

“…Lectin activity has been detected in the thigh muscle extracts of Rana tigerina, which was found to agglutinate both trypsinized and untrypsinized rabbit…”
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The Interaction of NADPH-P450 Reductase with P450: An Electrochemical Study of the Role of the Flavin Mononucleotide-Binding Domain by Estabrook, Ronald W., Shet, Manjunath S., Fisher, Charles W., Jenkins, Christopher M., Waterman, Michael R.

“…The electrochemically reduced mediator cobalt se- pulchrate requires the presence of a flavoprotein for the rapid transfer of electrons to cytochrome P450…”
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Effect of raw winged bean [Psophocarpus tetragonolobus (L.) DC] tuber lectin on gastrointestinal tract of growing rats by Shet, M S, Madaiah, M, Ahamed, R N

“…The fraction containing high hemagglutinating activity was prepared from raw winged bean tubers and orally administered to growing rats. The food intake and…”
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Purification and enzymatic properties of a recombinant fusion protein expressed in Escherichia coli containing the domains of bovine P450 17A and rat NADPH-P450 reductase by Shet, M S, Fisher, C W, Arlotto, M P, Shackleton, C H, Holmans, P L, Martin-Wixtrom, C A, Saeki, Y, Estabrook, R W

“…A fusion protein containing the heme domain of bovine cytochrome P450 17A and the flavin domains of rat NADPH-cytochrome P450 reductase has been genetically…”
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Construction of plasmids and expression in Escherichia coli of enzymatically active fusion proteins containing the heme-domain of a P450 linked to NADPH-P450 reductase by Fisher, C W, Shet, M S, Estabrook, R W

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The use of electrochemistry for the synthesis of 17 alpha-hydroxyprogesterone by a fusion protein containing P450c17 by Estabrook, R W, Shet, M S, Faulkner, K, Fisher, C W

“…A method has been developed for the commercial application of the unique oxygen chemistry catalyzed by various cytochrome P450s. This is illustrated here for…”
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Cancer mortality in India: a nationally representative survey by Dikshit, Rajesh, PhD, Gupta, Prakash C, DSc, Ramasundarahettige, Chinthanie, MSc, Gajalakshmi, Vendhan, PhD, Aleksandrowicz, Lukasz, MSc, Badwe, Rajendra, MS, Kumar, Rajesh, Prof, Roy, Sandip, MD, Suraweera, Wilson, MSc, Bray, Freddie, PhD, Mallath, Mohandas, MD, Singh, Poonam K, PhD, Sinha, Dhirendra N, MD, Shet, Arun S, MD, Gelband, Hellen, PhD, Jha, Prabhat, Prof

“…Summary Background The age-specific mortality rates and total deaths from specific cancers have not been documented for the various regions and subpopulations…”
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LECTIN ACTIVITY IN DIFFERENT PLANT TUBERS, RHIZOMES AND BULBS by SHET, M. S., MADAIAH, M.

“…Considerable lectin activity was detected in plant tubers, rhizomes and bulbs except Allium cepa. The maximum hemagglutinating activity was detected in…”
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Once-Weekly Transdermal Buprenorphine Application Results in Sustained and Consistent Steady-State Plasma Levels by Kapil, Ram P., PhD, Cipriano, Alessandra, BS, Friedman, Kristen, MPH, Michels, Gregory, MS, Shet, Manjunath S., PhD, Colucci, Salvatore V., MS, Apseloff, Glen, MD, FCP, Kitzmiller, Joseph, MD, PhD, CPI, Harris, Stephen C., MD

“…Abstract Context Transdermal formulations of buprenorphine offer controlled delivery of buprenorphine for sustained analgesic efficacy with reduced adverse…”
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