Search Results - "Sherwood, Edward R."

Trained immunity, tolerance, priming and differentiation: distinct immunological processes by Divangahi, Maziar, Aaby, Peter, Khader, Shabaana Abdul, Barreiro, Luis B., Bekkering, Siroon, Chavakis, Triantafyllos, van Crevel, Reinout, Curtis, Nigel, DiNardo, Andrew R., Dominguez-Andres, Jorge, Duivenvoorden, Raphael, Fanucchi, Stephanie, Fayad, Zahi, Fuchs, Elaine, Hamon, Melanie, Jeffrey, Kate L., Khan, Nargis, Joosten, Leo A. B., Kaufmann, Eva, Latz, Eicke, Matarese, Giuseppe, van der Meer, Jos W. M., Mhlanga, Musa, Moorlag, Simone J. C. F. M., Mulder, Willem J. M., Naik, Shruti, Novakovic, Boris, O’Neill, Luke, Ochando, Jordi, Ozato, Keiko, Riksen, Niels P., Sauerwein, Robert, Sherwood, Edward R., Schlitzer, Andreas, Schultze, Joachim L., Sieweke, Michael H., Benn, Christine Stabell, Stunnenberg, Henk, Sun, Joseph, van de Veerdonk, Frank L., Weis, Sebastian, Williams, David L., Xavier, Ramnik, Netea, Mihai G.

“…The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the…”
Get full text

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression by Patil, Naeem K., Bohannon, Julia K., Sherwood, Edward R.

“…[Display omitted] Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection (Third International Consensus…”
Get full text

Targeting Immune Cell Checkpoints during Sepsis by Patil, Naeem K, Guo, Yin, Luan, Liming, Sherwood, Edward R

“…Immunosuppression is increasingly being recognized as one of the causes of increased morbidity and mortality during sepsis. Both innate and adaptive immune…”
Get full text

Getting sepsis therapy right by Hotchkiss, Richard S, Sherwood, Edward R

“…Is decreasing inflammation or increasing the host immune response the better approach? [Also see Report by Weber et al. ] Sepsis—a complication of infection—is…”
Get full text

Regulation of leukocyte function by citric acid cycle intermediates by Patil, Naeem K., Bohannon, Julia K., Hernandez, Antonio, Patil, Tazeen K., Sherwood, Edward R.

“…Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle…”
Get full text

Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression by McBride, Margaret A, Patil, Tazeen K, Bohannon, Julia K, Hernandez, Antonio, Sherwood, Edward R, Patil, Naeem K

“…Sepsis is a leading cause of death in intensive care units and survivors develop prolonged immunosuppression and a high incidence of recurrent infections. No…”
Get full text

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages by Owen, Allison M, Luan, Liming, Burelbach, Katherine R, McBride, Margaret A, Stothers, Cody L, Boykin, Olivia A, Sivanesam, Kalkena, Schaedel, Jessica F, Patil, Tazeen K, Wang, Jingbin, Hernandez, Antonio, Patil, Naeem K, Sherwood, Edward R, Bohannon, Julia K

“…Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are…”
Get full text

The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma by McBride, Margaret A, Owen, Allison M, Stothers, Cody L, Hernandez, Antonio, Luan, Liming, Burelbach, Katherine R, Patil, Tazeen K, Bohannon, Julia K, Sherwood, Edward R, Patil, Naeem K

“…Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary infections during hospitalization and after hospital discharge…”
Get full text

Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection by Hernandez, Antonio, Patil, Naeem K., Stothers, Cody L., Luan, Liming, McBride, Margaret A., Owen, Allison M., Burelbach, Katherine R., Williams, David L., Sherwood, Edward R., Bohannon, Julia K.

“…[Display omitted] Infectious diseases remain a threat to critically ill patients, particularly with the rise of antibiotic-resistant bacteria. Septic shock…”
Get full text

Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice by Bane, Jr, Charles E, Ivanov, Ivan, Matafonov, Anton, Boyd, Kelli L, Cheng, Qiufang, Sherwood, Edward R, Tucker, Erik I, Smiley, Stephen T, McCarty, Owen J T, Gruber, Andras, Gailani, David

“…Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis…”
Get full text

Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway by Watts, 3rd, Bruns A, George, Thampi, Sherwood, Edward R, Good, David W

“…Monophosphoryl lipid A (MPLA) is a detoxified derivative of LPS that induces tolerance to LPS and augments host resistance to bacterial infections. Previously,…”
Get more information

Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis by Gill, P Spencer, Ozment, Tammy R, Lewis, Nicole H, Sherwood, Edward R, Williams, David L

“…Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity…”
Get full text

The Toll-Like Receptor 4 Agonist Monophosphoryl Lipid A Augments Innate Host Resistance to Systemic Bacterial Infection by ROMERO, Christopher D, VARMA, Tushar K, HOBBS, Jason B, REYES, Aimee, DRIVER, Brandon, SHERWOOD, Edward R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Endothelial cell tolerance to lipopolysaccharide challenge is induced by monophosphoryl lipid A by Stark, Ryan J, Choi, Hyehun, Koch, Stephen R, Fensterheim, Benjamin A, Lamb, Fred S, Sherwood, Edward R

“…Prior exposure to lipopolysaccharide (LPS) produces a reduced or "tolerant" inflammatory response to subsequent challenges with LPS, however the potent…”
Get more information

IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection by Patil, Naeem K, Luan, Liming, Bohannon, Julia K, Guo, Yin, Hernandez, Antonio, Fensterheim, Benjamin, Sherwood, Edward R

“…Severely burned patients are highly susceptible to opportunistic infections and sepsis, owing to the loss of the protective skin barrier and immunological…”
Get full text

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes by Divangahi, Maziar, Aaby, Peter, Khader, Shabaana Abdul, Barreiro, Luis B., Bekkering, Siroon, Chavakis, Triantafyllos, van Crevel, Reinout, Curtis, Nigel, DiNardo, Andrew R., Dominguez-Andres, Jorge, Duivenvoorden, Raphael, Fanucchi, Stephanie, Fayad, Zahi, Fuchs, Elaine, Hamon, Melanie, Jeffrey, Kate L., Khan, Nargis, Joosten, Leo A. B., Kaufmann, Eva, Latz, Eicke, Matarese, Giuseppe, van der Meer, Jos W. M., Mhlanga, Musa, Moorlag, Simone J. C. F. M., Mulder, Willem J. M., Naik, Shruti, Novakovic, Boris, O’Neill, Luke, Ochando, Jordi, Ozato, Keiko, Riksen, Niels P., Sauerwein, Robert, Sherwood, Edward R., Schlitzer, Andreas, Schultze, Joachim L., Sieweke, Michael H., Benn, Christine Stabell, Stunnenberg, Henk, Sun, Joseph, van de Veerdonk, Frank L., Weis, Sebastian, Williams, David L., Xavier, Ramnik, Netea, Mihai G.

Get full text

Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A by Enkhbaatar, Perenlei, Nelson, Christina, Salsbury, John R, Carmical, Joseph R, Torres, Karen E O, Herndon, David, Prough, Donald S, Luan, Liming, Sherwood, Edward R

“…Animal models that mimic human biology are important for successful translation of basic science discoveries into the clinical practice. Recent studies in…”
Get full text

STAT1-deficient mice are resistant to cecal ligation and puncture-induced septic shock by Herzig, Daniela, Fang, Geping, Toliver-Kinsky, Tracy E, Guo, Yin, Bohannon, Julia, Sherwood, Edward R

“…STAT1 (signal transducer and activator of transcription 1) is a member of the JAK-STAT signaling family and plays a key role in facilitating gene transcription…”
Get full text

The role of interferon-γ in the pathogenesis of acute intra-abdominal sepsis by Romero, Christopher R., Herzig, Daniela S., Etogo, Anthony, Nunez, Jesus, Mahmoudizad, Rod, Fang, Geping, Murphey, E. D., Toliver‐Kinsky, Tracy, Sherwood, Edward R.

“…IFNγ produced by intraperitoneal myeloid and NK cells during cecal ligation/puncture‐induced septic shock facilitates myeloid cell activation yet blockade of…”
Get full text

Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent by Guo, Yin, Luan, Liming, Patil, Naeem K., Sherwood, Edward R.

“…[Display omitted] •IL-15 potently activates natural killer, NKT and memory CD8+ T cells and is crucial for their normal growth and differentiation.•The…”
Get full text