Search Results - "Sherwood, Edward"

Targeting Immune Cell Checkpoints during Sepsis by Patil, Naeem K, Guo, Yin, Luan, Liming, Sherwood, Edward R

“…Immunosuppression is increasingly being recognized as one of the causes of increased morbidity and mortality during sepsis. Both innate and adaptive immune…”
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Trained immunity, tolerance, priming and differentiation: distinct immunological processes by Divangahi, Maziar, Aaby, Peter, Khader, Shabaana Abdul, Barreiro, Luis B., Bekkering, Siroon, Chavakis, Triantafyllos, van Crevel, Reinout, Curtis, Nigel, DiNardo, Andrew R., Dominguez-Andres, Jorge, Duivenvoorden, Raphael, Fanucchi, Stephanie, Fayad, Zahi, Fuchs, Elaine, Hamon, Melanie, Jeffrey, Kate L., Khan, Nargis, Joosten, Leo A. B., Kaufmann, Eva, Latz, Eicke, Matarese, Giuseppe, van der Meer, Jos W. M., Mhlanga, Musa, Moorlag, Simone J. C. F. M., Mulder, Willem J. M., Naik, Shruti, Novakovic, Boris, O’Neill, Luke, Ochando, Jordi, Ozato, Keiko, Riksen, Niels P., Sauerwein, Robert, Sherwood, Edward R., Schlitzer, Andreas, Schultze, Joachim L., Sieweke, Michael H., Benn, Christine Stabell, Stunnenberg, Henk, Sun, Joseph, van de Veerdonk, Frank L., Weis, Sebastian, Williams, David L., Xavier, Ramnik, Netea, Mihai G.

“…The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the…”
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Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent by Guo, Yin, Luan, Liming, Patil, Naeem K., Sherwood, Edward R.

“…[Display omitted] •IL-15 potently activates natural killer, NKT and memory CD8+ T cells and is crucial for their normal growth and differentiation.•The…”
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Residual Mechanical Response of Recycled Aggregate Concrete after Exposure to Elevated Temperatures by Sarhat, Salah R, Sherwood, Edward. G

“…AbstractA considerable number of investigations have been conducted on the mechanical and material properties of concrete made with recycled concrete aggregate…”
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Human activities and climate variability drive fast‐paced change across the world's estuarine–coastal ecosystems by Cloern, James E., Abreu, Paulo C., Carstensen, Jacob, Chauvaud, Laurent, Elmgren, Ragnar, Grall, Jacques, Greening, Holly, Johansson, John Olov Roger, Kahru, Mati, Sherwood, Edward T., Xu, Jie, Yin, Kedong

“…Time series of environmental measurements are essential for detecting, measuring and understanding changes in the Earth system and its biological communities…”
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Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression by Patil, Naeem K., Bohannon, Julia K., Sherwood, Edward R.

“…[Display omitted] Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection (Third International Consensus…”
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Getting sepsis therapy right by Hotchkiss, Richard S, Sherwood, Edward R

“…Is decreasing inflammation or increasing the host immune response the better approach? [Also see Report by Weber et al. ] Sepsis—a complication of infection—is…”
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The biology of natural killer cells during sepsis by Guo, Yin, Patil, Naeem K., Luan, Liming, Bohannon, Julia K., Sherwood, Edward R.

“…Summary Natural killer (NK) cells are large granular lymphocytes largely recognized for their importance in tumour surveillance and the host response to viral…”
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Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice by Bane, Jr, Charles E, Ivanov, Ivan, Matafonov, Anton, Boyd, Kelli L, Cheng, Qiufang, Sherwood, Edward R, Tucker, Erik I, Smiley, Stephen T, McCarty, Owen J T, Gruber, Andras, Gailani, David

“…Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis…”
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Regulation of leukocyte function by citric acid cycle intermediates by Patil, Naeem K., Bohannon, Julia K., Hernandez, Antonio, Patil, Tazeen K., Sherwood, Edward R.

“…Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle…”
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MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages by Owen, Allison M, Luan, Liming, Burelbach, Katherine R, McBride, Margaret A, Stothers, Cody L, Boykin, Olivia A, Sivanesam, Kalkena, Schaedel, Jessica F, Patil, Tazeen K, Wang, Jingbin, Hernandez, Antonio, Patil, Naeem K, Sherwood, Edward R, Bohannon, Julia K

“…Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are…”
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Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression by McBride, Margaret A, Patil, Tazeen K, Bohannon, Julia K, Hernandez, Antonio, Sherwood, Edward R, Patil, Naeem K

“…Sepsis is a leading cause of death in intensive care units and survivors develop prolonged immunosuppression and a high incidence of recurrent infections. No…”
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IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ by Guo, Yin, Luan, Liming, Rabacal, Whitney, Bohannon, Julia K, Fensterheim, Benjamin A, Hernandez, Antonio, Sherwood, Edward R

“…IL-15 is currently undergoing clinical trials to assess its efficacy for treatment of advanced cancers. The combination of IL-15 with soluble IL-15Rα generates…”
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Frontline Science: Anti‐PD‐L1 protects against infection with common bacterial pathogens after burn injury by Patil, Naeem K., Luan, Liming, Bohannon, Julia K., Hernandez, Antonio, Guo, Yin, Sherwood, Edward R.

“…Burn patients are susceptible to infections due, in part, to immune dysfunction. Upregulation of programmed death‐1 (PD‐1) receptor on T cells and programmed…”
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Reversal of sepsis‐induced T cell dysfunction: OX‐40 to the rescue? by Sherwood, Edward R., Williams, David L.

“…Graphical The study of Unsinger and colleagues provide important insights into OX40 mediated immunotherapy as a potential approach for the treatment of sepsis…”
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The prediction of compressive strength of ungrouted hollow concrete block masonry by Sarhat, Salah R., Sherwood, Edward G.

“…•A large database of compressive test results on ungrouted masonry was assembled from literature.•Collected data was used to develop a formula to predict…”
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A Murky Ruling Threatens the Fate of Millions of US Wetlands by Simmons, B. Alexander, Beck, Marcus W., Flaherty-Walia, Kerry, Lewis, Jessica, Sherwood, Edward T.

“…For decades, federal protections were extended to wetlands adjacent to “waters of the US” by the Clean Water Act. In its Sackett v. EPA ruling, however, the US…”
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The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma by McBride, Margaret A, Owen, Allison M, Stothers, Cody L, Hernandez, Antonio, Luan, Liming, Burelbach, Katherine R, Patil, Tazeen K, Bohannon, Julia K, Sherwood, Edward R, Patil, Naeem K

“…Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary infections during hospitalization and after hospital discharge…”
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β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages by Stothers, Cody L, Burelbach, Katherine R, Owen, Allison M, Patil, Naeem K, McBride, Margaret A, Bohannon, Julia K, Luan, Liming, Hernandez, Antonio, Patil, Tazeen K, Williams, David L, Sherwood, Edward R

“…Bacterial infections are a common and deadly threat to vulnerable patients. Alternative strategies to fight infection are needed. β-Glucan, an immunomodulator…”
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The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection by Fensterheim, Benjamin A, Guo, Yin, Sherwood, Edward R, Bohannon, Julia K

“…The magnitude of the LPS-elicited cytokine response is commonly used to assess immune function in critically ill patients. A suppressed response, known as…”
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