Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure

Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure

Aims We studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF). Methods and results We enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LVEF) <4...

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Published in:ESC Heart Failure Vol. 7; no. 3; pp. 1101 - 1108
Main Authors: Dos Santos, Marcelo Rodrigues, Fonseca, Guilherme Wesley Peixoto, Sherveninas, Letícia Pironato, Souza, Francis Ribeiro, Battaglia Filho, Antônio Carlos, Novaes, Caio Eduardo, Pereira, Rosa Maria Rodrigues, Negrão, Carlos Eduardo, Barretto, Antônio Carlos Pereira, Alves, Maria‐Janieire de Nazaré Nunes
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01-06-2020
John Wiley and Sons Inc
Wiley
Subjects:
Blood pressure
Body composition
Body mass index
Cholesterol
Creatinine
Diabetes
Ejection fraction
Enzymes
Fat distribution
Heart failure
Hemoglobin
Laboratories
Obesity
Original
Original s
Overweight
Oxygen consumption
Potassium
Sarcopenia
Testosterone
Thyroid gland
Workloads
New York
Heart failure
Oxygen consumption
Fat distribution
Body composition
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Summary:Aims We studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF). Methods and results We enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LVEF) <40%. Body composition (by using dual x‐ray absorptiometry) and peak VO2 (by cardiopulmonary exercise testing) were measured. Sarcopenic obesity was defined according to the Foundation for the National Institutes of Health criteria (FNIH). Blood sample for metabolic and hormonal parameters were measured. Fifteen patients (12.7%) showed sarcopenic obesity (body mass index > 25 kg/m2 with FNIH index < 0.789). The median A/G ratio was 0.55. A/G ratio > 0.55 was detected in 60 patients. Relative peak VO2 was lower in patients with A/G ratio > 0.55 than in patients with A/G ratio <0.55 (18.7 ± 5.3 vs. 22.5 ± 6.1 mL/kg/min, P < 0.001). Logistic regression analysis showed A/G ratio >0.55 to be independently associated with reduced peak VO2 adjusted for age, body mass index, LVEF, presence of sarcopenia, anabolic hormones, and haemoglobin (odds ratio 3.895, 95% confidence interval 1.030–14.730, P = 0.045). Conclusions Body fat distribution, particularly android and gynoid fat composition, together with other cofactors, might have an important adverse role on functional capacity in male patients with HFrEF. Future studies are needed to address possible mechanisms involved in this relationship.
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ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.12657