Search Results - "Sherry, Alexander D."
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Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial
Published in JAMA oncology (01-06-2023)“…Despite evidence demonstrating an overall survival benefit with up-front hormone therapy in addition to established synergy between hormone therapy and…”
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Systemic inflammatory dynamics during chemoradiotherapy predict response, relapse, metastasis, and survival in esophageal carcinoma
Published in Journal of surgical oncology (01-02-2020)“…Background and Objectives Lymphopenia associated with chemoradiotherapy predicts prognosis in esophageal carcinoma. The purpose of our study was to evaluate…”
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Predictors of Recurrence After Sub-total or Near-total Resection of Vestibular Schwannoma: Importance of Tumor Volume and Ventral Extension
Published in Otology & neurotology (01-06-2022)“…To evaluate the predictors of remnant tumor regrowth and need for salvage therapy after less than gross total resection (GTR) of vestibular schwannoma (VS)…”
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A meta-epidemiological analysis of post-hoc comparisons and primary endpoint interpretability among randomized noncomparative trials in clinical medicine
Published in Journal of clinical epidemiology (01-11-2024)“…Randomized noncomparative trials (RNCTs) promise reduced accrual requirements vs randomized controlled comparative trials because RNCTs do not enroll a control…”
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Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life
Published in International journal of particle therapy (01-06-2021)“…PURPOSEProton radiation therapy (PRT) may offer dosimetric and clinical benefit in the treatment of head and neck carcinoma of unknown primary (HNCUP). We…”
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Challenges, Complexities, and Considerations in the Design and Interpretation of Late-Phase Oncology Trials
Published in Seminars in radiation oncology (01-10-2023)“…Optimal management of cancer patients relies heavily on late-phase oncology randomized controlled trials. A comprehensive understanding of the key…”
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Lost in the plot: missing visual elements in Kaplan-Meier plots of phase III oncology trials
Published in The oncologist (Dayton, Ohio) (05-07-2024)“…Missing visual elements (MVE) in Kaplan-Meier (KM) curves can misrepresent data, preclude curve reconstruction, and hamper transparency. This study evaluated…”
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Systemic Inflammation After Radiation Predicts Locoregional Recurrence, Progression, and Mortality in Stage II-III Triple-Negative Breast Cancer
Published in International journal of radiation oncology, biology, physics (01-09-2020)“…Patients with triple-negative breast cancer experience high rates of recurrence after radiation, which may be facilitated by the recruitment of circulating…”
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Prevalence, trends, and characteristics of trials investigating local therapy in contemporary phase 3 clinical cancer research
Published in Cancer (01-11-2023)“…Although most patients with cancer are treated with local therapy (LT), the proportion of late-phase clinical trials investigating local therapeutic…”
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Metastases-Targeting Radiotherapy and ADT-Reply
Published in JAMA oncology (01-11-2023)Get more information
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Feasibility and Tolerability of Adjuvant Capecitabine-Based Chemoradiation in Patients With Breast Cancer and Residual Disease After Neoadjuvant Chemotherapy: A Prospective Clinical Trial
Published in International journal of radiation oncology, biology, physics (01-04-2024)“…Addition of adjuvant capecitabine improves overall survival for patients with breast cancer lacking pathologic complete response to standard-of-care…”
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Mean cardiopulmonary dose and vertebral marrow dose differentially predict lineage-specific leukopenia kinetics during radiotherapy for esophageal cancer
Published in Radiotherapy and oncology (01-11-2020)“…•Hematologic toxicity is known to predict poor outcomes in esophageal cancer (EC).•Off-target radiation during treatment for EC predicts lineage-specific…”
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Definitive Local Consolidative Therapy for Oligometastatic Solid Tumors: Results From the Lead-in Phase of the Randomized Basket Trial EXTEND
Published in International journal of radiation oncology, biology, physics (01-12-2022)“…The benefit of local consolidative therapy (LCT) for oligometastasis across histologies remains uncertain. EXTernal beam radiation to Eliminate Nominal…”
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Off-Protocol Radiation Therapy in Phase 3 Metastatic Solid Tumor Trials
Published in International journal of radiation oncology, biology, physics (01-12-2024)“…Increasing data suggest that radiation therapy, particularly ablative radiation therapy, alters the natural history of metastatic disease. For patients with…”
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Improving the clinical meaning of surrogate endpoints: An empirical assessment of clinical progression in phase III oncology trials
Published in International journal of cancer (01-12-2024)“…Disease progression in clinical trials is commonly defined by radiologic measures. However, clinical progression may be more meaningful to patients, may occur…”
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Prevalence and implications of significance testing for baseline covariate imbalance in randomised cancer clinical trials: The Table 1 Fallacy
Published in European journal of cancer (1990) (01-11-2023)“…The ‘Table 1 Fallacy’ refers to the unsound use of significance testing for comparing the distributions of baseline variables between randomised groups to draw…”
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Noninvasive Thalamotomy for Refractory Tremor by Frameless Radiosurgery
Published in International journal of radiation oncology, biology, physics (01-01-2022)“…We sought to determine whether a more widely accessible, noninvasive, frameless approach to radiosurgical thalamotomy would improve objective measures of…”
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Noninvasive Capsulotomy for Refractory Depression by Frameless Stereotactic Radiosurgery
Published in International journal of radiation oncology, biology, physics (01-08-2022)“…Effective treatment options for refractory depression are needed. Recent advancements permit both precise ablative radiation and functional neurologic…”
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