Search Results - "Sherrington, P D"

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53 ATM status in chronic lymphocytic leukaemia cells by Lin, K, Rockliffe, N, Johnson, G G, Sherrington, P D, Pettitt, A R

“…In chronic lymphocytic leukaemia (CLL), mutation/deletion of TP53 is strongly associated with early disease progression, resistance to chemotherapy and short…”
Get full text

Detection of p53 dysfunction by flow cytometry in chronic lymphocytic leukaemia by Carter, A., Lin, K., Sherrington, P. D., Pettitt, A. R.

“…Summary In chronic lymphocytic leukaemia (CLL) cells, functional impairment of the p53 pathway is detectable by Western blotting as impaired up‐regulation of…”
Get full text

Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues by PETTITT, A. R, SHERRINGTON, P. D, CAWLEY, J. C

“…Although the nucleoside analogues fludarabine and chlorodeoxyadenosine have become important therapeutic agents in chronic lymphocytic leukemia (CLL), their…”
Get full text

Analysis of VH gene sequences using two web-based immunogenetics resources gives different results, but the affinity maturation status of chronic lymphocytic leukaemia clones as assessed from either of the resulting data sets has no prognostic significance by LANE, B. S, MENSAH, A. A, LIN, K, PETTITT, A. R, SHERRINGTON, P. D

“…Some cellular and molecular features of chronic lymphocytic leukaemia (CLL) cells that are associated with prognosis may reflect the context within which their…”
Get full text

Imperfect correlation between p53 dysfunction and deletion of TP53 and ATM in chronic lymphocytic leukaemia by Carter, A, Lin, K, Sherrington, P D, Atherton, M, Pearson, K, Douglas, A, Burford, A, Brito-Babapulle, V, Matutes, E, Catovsky, D, Pettitt, A R

Get full text

The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia by PETTITT, A. R, SHERRINGTON, P. D, CAWLEY, J. C

“…To clarify the role of p53 in the killing of chronic lymphocytic leukaemia (CLL) cells by purine analogues, we examined the cytotoxic effects of…”
Get full text

The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another by Fisch, P, Forster, A, Sherrington, P D, Dyer, M J, Rabbitts, T H

“…Chromosomal translocation t(X;14)(q28;q11) has been observed in patients with pro-lymphocytic T-cell leukaemia (T-PLL). In two cases of T-PLL, one of which was…”
Get more information

p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation by PETTITT, Andrew R, SHERRINGTON, Paul D, STEWART, Grant, CAWLEY, John C, TAYLOR, A. Malcolm R, STANKOVIC, Tatjana

“…The well-established association between TP53 mutations and adverse clinical outcome in a range of human cancers reflects the importance of p53 protein in…”
Get full text

A Ki-1 (CD30)-Positive Human Cell Line (Karpas 299) Established From a High-Grade Non-Hodgkin's Lymphoma, Showing a 2;5 Translocation and Rearrangement of the T-Cell Receptor β-Chain Gene by Fischer, Patricia, Nacheva, Elisabeth, Mason, David Y., Sherrington, Paul D., Hoyle, Christine, Hayhoe, Frank G.J., Karpas, Abraham

“…We describe the characterization of a new human cell line, Karpas 299 (K299), established from blast cells in the peripheral blood of a 25-year-old white man…”
Get full text

Analysis of a T-Cell Tumor-Specific Breakpoint Cluster at Human Chromosome 14q32 by Mengle-Gaw, Laurel, Albertson, Donna G., Sherrington, Paul D., Rabbitts, Terence H.

“…Cytogenetic abnormalities involving chromosome 14 band q32 are consistently observed in human T-cell tumors. Patients with ataxia-telangiectasia (AT) are…”
Get full text

The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes by JONES, Gillian G, REAPER, Philip M, PETTITT, Andrew R, SHERRINGTON, Paul D

“…Chronic lymphocytic leukaemia (CLL) results from the accumulation of apoptosis-resistant clonal B cells that are arrested in G0/G1, and is heterogeneous with…”
Get full text

Localization of polymorphic DNA probes frequently deleted in lung carcinoma by ALBERTSON, D. G, SHERRINGTON, P. D, RABBITTS, P. H

“…Five polymorphic DNA segments from human chromosome 3, that are frequently deleted in lung carcinoma were mapped by non-isotopic in situ hybridization to…”
Get full text

Molecular analysis of a new translocation, t(X;14)(q28;q11), in premalignancy and in leukaemia associated with ataxia telangiectasia by Thick, J, Sherrington, P D, Fisch, P, Taylor, A M, Rabbitts, T H

“…The disease ataxia telangiectasia (A-T) is a multifaceted disorder in which patients have an increased chance of developing a T-cell leukaemia, often with…”
Get more information

Basophils in acute myeloid leukaemia by Hoyle, C F, Sherrington, P D, Fischer, P, Hayhoe, F G

“…Thirty four out of 750 patients entered into the Medical Research Council's (MRC) 9th Acute Myeloid Leukaemia Trial had more than 1% basophils (range 1-27%)…”
Get full text

Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia by ROMANOV, Vadim V, JAMES, Christine H, SHERRINGTON, Paul D, PETTITT, Andrew R

“…p53 is the most frequently inactivated gene in human cancers, reflecting its pivotal role in maintaining genomic integrity. The present study was conducted to…”
Get full text

Cytological features of 9q- deletions in AML by Hoyle, C, Sherrington, P D, Hayhoe, F G

Get more information

AML associated with previous cytotoxic therapy, MDS or myeloproliferative disorders: results from the MRC's 9th AML trial by Hoyle, C F, de Bastos, M, Wheatley, K, Sherrington, P D, Fischer, P J, Rees, J K, Gray, R, Hayhoe, F G

“…The outcome of treatment with standard first line therapy of 66 patients with acute myeloid leukaemia (AML) secondary to preceding chemotherapy (Group 1), a…”
Get more information

Granuloctye-Macrophage Colony-Stimulating Factor as an Autocrine Survival Factor for Mature Normal and Malignant B Lymphocytes by Harris, Robert J, Pettitt, Andrew R, Schmutz, Caroline, Sherrington, Paul D, Zuzel, Mirko, Cawley, John C, Griffiths, Stephen D

“…The role of GM-CSF in B cell (patho)physiology is unclear. Although B cells can respond to GM-CSF, there is controversy concerning the extent to which various…”
Get full text

Clonal evolution of malignant and non-malignant T cells carrying t(14;14) and t(X;14) in patients with ataxia telangiectasia by Sherrington, P D, Fisch, P, Taylor, A M, Rabbitts, T H

“…People with ataxia telangiectasia (AT) are at a higher than normal risk of T cell leukaemia and often have either non-malignant or malignant T cells with…”
Get more information

TLiSA1 (PTA1) Activation Antigen Implicated in T Cell Differentiation and Platelet Activation Is a Member of the Immunoglobulin Superfamily Exhibiting Distinctive Regulation of Expression by Sherrington, Paul D., Scott, Judith L., Jin, Boquan, Simmons, David, Dorahy, Douglas J., Lloyd, Jennifer, Brien, Joan H., Aebersold, Ruedi H., Adamson, Janet, Zuzel, Mirko, Burns, Gordon F.

“…T lineage-specific activation antigen 1 (TLiSA1) antigen was initially described as a T lineage-specific activation antigen involved in the differentiation of…”
Get full text